<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:b85afe04-e10c-4b1e-ab06-b188536ca151,g:2dcf3dec-0ec6-48cb-915b-a308cf78e7ee-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="simple" xlink:href="endp-20230331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_24be4a31-fe63-470c-8831-cf94d5b49cd8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_Goodwill_24be4a31-fe63-470c-8831-cf94d5b49cd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_9d3158b9-59ae-4b0c-93f2-3d5beedc1ecb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_AssetsCurrent_9d3158b9-59ae-4b0c-93f2-3d5beedc1ecb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_8f791ad6-01b4-485b-affd-6afeb9a195fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_8f791ad6-01b4-485b-affd-6afeb9a195fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_3ea98766-e8a8-41d5-9721-3f69fee7e79e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_3ea98766-e8a8-41d5-9721-3f69fee7e79e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_9303dd96-3b60-47b3-896b-9f87376ae38e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_9303dd96-3b60-47b3-896b-9f87376ae38e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_27f6c8f7-da40-4212-bfde-f05f523a92c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_27f6c8f7-da40-4212-bfde-f05f523a92c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_d5fe3d03-3b79-4476-897f-7d90e25eea93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_d5fe3d03-3b79-4476-897f-7d90e25eea93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_590552a3-397f-4b38-a7eb-557f7dcb728d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_590552a3-397f-4b38-a7eb-557f7dcb728d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DueFromAffiliateNoncurrent_bf60e6d2-0bcb-408d-8238-d26716980b5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueFromAffiliateNoncurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e3bd35ec-5333-4b1e-a38b-d2c50da875c5" xlink:to="loc_us-gaap_DueFromAffiliateNoncurrent_bf60e6d2-0bcb-408d-8238-d26716980b5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_5e8c9745-f50d-43a3-a3f5-a7f6f61f3db8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_544acfde-34e5-4240-acc9-3202fbec9f84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5e8c9745-f50d-43a3-a3f5-a7f6f61f3db8" xlink:to="loc_us-gaap_CommitmentsAndContingencies_544acfde-34e5-4240-acc9-3202fbec9f84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesSubjectToCompromise_519f9d79-280b-4d14-b04a-406beeee20b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesSubjectToCompromise"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5e8c9745-f50d-43a3-a3f5-a7f6f61f3db8" xlink:to="loc_us-gaap_LiabilitiesSubjectToCompromise_519f9d79-280b-4d14-b04a-406beeee20b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_b9421aa2-e6df-4df6-955b-52c1030ca435" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5e8c9745-f50d-43a3-a3f5-a7f6f61f3db8" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_b9421aa2-e6df-4df6-955b-52c1030ca435" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_50be9ed7-3697-4d0b-9c4a-bf75bdd6e141" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5e8c9745-f50d-43a3-a3f5-a7f6f61f3db8" xlink:to="loc_us-gaap_StockholdersEquity_50be9ed7-3697-4d0b-9c4a-bf75bdd6e141" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_d18bb381-8175-4fb0-ae2e-c003d8c66018" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5e8c9745-f50d-43a3-a3f5-a7f6f61f3db8" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_d18bb381-8175-4fb0-ae2e-c003d8c66018" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_3e64375f-42de-4484-ac5b-46e35ffed34a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5e8c9745-f50d-43a3-a3f5-a7f6f61f3db8" xlink:to="loc_us-gaap_LiabilitiesCurrent_3e64375f-42de-4484-ac5b-46e35ffed34a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_5f813641-f369-4d1a-90fe-d1941536fe77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5e8c9745-f50d-43a3-a3f5-a7f6f61f3db8" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_5f813641-f369-4d1a-90fe-d1941536fe77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_6759401d-ada3-4c36-bee5-6dfeece138d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EuroDeferredStockValueIssued_9b78486e-591d-44b3-8066-6db615e11521" xlink:href="endp-20230331.xsd#endp_EuroDeferredStockValueIssued"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_6759401d-ada3-4c36-bee5-6dfeece138d1" xlink:to="loc_endp_EuroDeferredStockValueIssued_9b78486e-591d-44b3-8066-6db615e11521" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_e05dc9a2-2391-4132-be52-4fd8c837dbc3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_6759401d-ada3-4c36-bee5-6dfeece138d1" xlink:to="loc_us-gaap_CommonStockValue_e05dc9a2-2391-4132-be52-4fd8c837dbc3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_f38b00ec-bfb4-4da1-8912-cd4a63e788dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_6759401d-ada3-4c36-bee5-6dfeece138d1" xlink:to="loc_us-gaap_AdditionalPaidInCapital_f38b00ec-bfb4-4da1-8912-cd4a63e788dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_b7c00ccc-d3ce-4839-9a6c-99beb7225c5e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_6759401d-ada3-4c36-bee5-6dfeece138d1" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_b7c00ccc-d3ce-4839-9a6c-99beb7225c5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_12d81e77-061a-4b71-afcc-2be16516dabd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_6759401d-ada3-4c36-bee5-6dfeece138d1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_12d81e77-061a-4b71-afcc-2be16516dabd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_863297f4-9646-4a27-b359-2956bdd13cbc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_67db85c5-ea30-4f66-8a3c-81d99355dc6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_863297f4-9646-4a27-b359-2956bdd13cbc" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_67db85c5-ea30-4f66-8a3c-81d99355dc6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_770e407f-bafd-4565-beed-2f7fd9d76bc7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_863297f4-9646-4a27-b359-2956bdd13cbc" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_770e407f-bafd-4565-beed-2f7fd9d76bc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_ec2c9816-8a40-4eed-a62f-eaa3fe2c277d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_863297f4-9646-4a27-b359-2956bdd13cbc" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_ec2c9816-8a40-4eed-a62f-eaa3fe2c277d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DueToAffiliateCurrent_365bc3fb-01d4-4c2b-ae88-66086cdb6081" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueToAffiliateCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_863297f4-9646-4a27-b359-2956bdd13cbc" xlink:to="loc_us-gaap_DueToAffiliateCurrent_365bc3fb-01d4-4c2b-ae88-66086cdb6081" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_54ebca70-5cb8-4dbe-b716-07843b5c1198" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_fde35e6f-8a02-49bf-ae11-d2a7925528f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_54ebca70-5cb8-4dbe-b716-07843b5c1198" xlink:to="loc_us-gaap_InventoryNet_fde35e6f-8a02-49bf-ae11-d2a7925528f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_bebcd30d-b2ba-41c0-8a3b-c04312fdf4b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_54ebca70-5cb8-4dbe-b716-07843b5c1198" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_bebcd30d-b2ba-41c0-8a3b-c04312fdf4b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_f73b243d-fbe1-42b4-af74-117608690579" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_54ebca70-5cb8-4dbe-b716-07843b5c1198" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_f73b243d-fbe1-42b4-af74-117608690579" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_001f5c56-26fb-444f-bafc-e7c9af87e3cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxesReceivable"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_54ebca70-5cb8-4dbe-b716-07843b5c1198" xlink:to="loc_us-gaap_IncomeTaxesReceivable_001f5c56-26fb-444f-bafc-e7c9af87e3cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_b7220331-92b2-4c8e-a995-acab73c50a89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_54ebca70-5cb8-4dbe-b716-07843b5c1198" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_b7220331-92b2-4c8e-a995-acab73c50a89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_fafe22d6-c969-4454-aa6b-abbda57e719a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_54ebca70-5cb8-4dbe-b716-07843b5c1198" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_fafe22d6-c969-4454-aa6b-abbda57e719a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DueFromAffiliateCurrent_f29c1641-494c-4772-87ea-a6355cc0a5b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueFromAffiliateCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_54ebca70-5cb8-4dbe-b716-07843b5c1198" xlink:to="loc_us-gaap_DueFromAffiliateCurrent_f29c1641-494c-4772-87ea-a6355cc0a5b1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="simple" xlink:href="endp-20230331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_8e3bee7b-b791-46ae-be52-87c9ebe08306" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_8e3bee7b-b791-46ae-be52-87c9ebe08306" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_55474b3d-a830-46d7-8ea3-01296f70dd17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_55474b3d-a830-46d7-8ea3-01296f70dd17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_c163b564-9def-4a17-8457-ee109b2fcba2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_c163b564-9def-4a17-8457-ee109b2fcba2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_bdf8828e-fad4-4880-8fc1-6544ef9ffd15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_AssetImpairmentCharges_bdf8828e-fad4-4880-8fc1-6544ef9ffd15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_c0b188ca-4ed5-41f4-94af-0bdeaafec8ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_InterestExpense_c0b188ca-4ed5-41f4-94af-0bdeaafec8ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_ad467e37-2d62-43a3-8810-5e7c9ffaf3d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_ad467e37-2d62-43a3-8810-5e7c9ffaf3d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentInProcess_102667cb-80c0-47ef-bf0c-75e9aa1ecf37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentInProcess"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_ResearchAndDevelopmentInProcess_102667cb-80c0-47ef-bf0c-75e9aa1ecf37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_f08c5d6f-8b69-400d-ab77-36bf719064e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_CostOfRevenue_f08c5d6f-8b69-400d-ab77-36bf719064e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReorganizationItems_feea15f4-3f08-444a-a2b6-bc31ca2351a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReorganizationItems"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_ReorganizationItems_feea15f4-3f08-444a-a2b6-bc31ca2351a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_4e8bcb0e-94b1-4ea3-98e7-b5e9a4653092" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_4e8bcb0e-94b1-4ea3-98e7-b5e9a4653092" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7c60bc3f-e44a-4116-b10e-4b5eabc5de52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e80b24e6-b1dc-438e-be73-88ab60c454d3" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7c60bc3f-e44a-4116-b10e-4b5eabc5de52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_2ae0e65f-c7d8-484c-bd5c-f77efeda37a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_1d4ce733-324f-46e9-a13b-ffdc9823a494" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_2ae0e65f-c7d8-484c-bd5c-f77efeda37a7" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_1d4ce733-324f-46e9-a13b-ffdc9823a494" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c9985a11-0d28-4689-ac3d-7a8398a23f60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_2ae0e65f-c7d8-484c-bd5c-f77efeda37a7" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c9985a11-0d28-4689-ac3d-7a8398a23f60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_9317a912-aad9-4a65-ba37-b5ca5266de55" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_7c7ffd8e-c006-4b33-8ea0-3601d34f0cf5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_9317a912-aad9-4a65-ba37-b5ca5266de55" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_7c7ffd8e-c006-4b33-8ea0-3601d34f0cf5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerBasicShare_4086f3dc-bbad-4ed7-8ce1-a08a092c13fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerBasicShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_9317a912-aad9-4a65-ba37-b5ca5266de55" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerBasicShare_4086f3dc-bbad-4ed7-8ce1-a08a092c13fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_c59af827-2630-4f20-b6ad-0dfa05038039" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_4151ca1e-7ddb-4c39-84e2-95cf222b6d34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_c59af827-2630-4f20-b6ad-0dfa05038039" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_4151ca1e-7ddb-4c39-84e2-95cf222b6d34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerDilutedShare_bcb595ed-fd61-486d-9b13-a2f823d15a02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerDilutedShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_c59af827-2630-4f20-b6ad-0dfa05038039" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerDilutedShare_bcb595ed-fd61-486d-9b13-a2f823d15a02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e4f9efbe-5633-4311-8405-01ac972876c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_3b80ef39-617d-4e80-916f-a6a0c616cd25" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_e4f9efbe-5633-4311-8405-01ac972876c6" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_3b80ef39-617d-4e80-916f-a6a0c616cd25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_8efc4ebd-7432-4b79-b23b-8b5b282779de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_e4f9efbe-5633-4311-8405-01ac972876c6" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_8efc4ebd-7432-4b79-b23b-8b5b282779de" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSUNAUDITED" xlink:type="simple" xlink:href="endp-20230331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_b5ef33a9-6a3e-44a5-8c35-e45dd9c60f85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b256987e-e94a-4b9e-8462-8fdbd75844e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_b5ef33a9-6a3e-44a5-8c35-e45dd9c60f85" xlink:to="loc_us-gaap_NetIncomeLoss_b256987e-e94a-4b9e-8462-8fdbd75844e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_20dbb5dc-f6bf-4543-ad5b-bc14131c04c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_b5ef33a9-6a3e-44a5-8c35-e45dd9c60f85" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_20dbb5dc-f6bf-4543-ad5b-bc14131c04c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_c217dc62-1cae-45f1-a6bd-7f9e75218b11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_20c0f185-5017-4982-953e-1bb65758548a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_c217dc62-1cae-45f1-a6bd-7f9e75218b11" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_20c0f185-5017-4982-953e-1bb65758548a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="simple" xlink:href="endp-20230331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_173cf7c0-638c-470e-89d9-c3064c4946cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_173cf7c0-638c-470e-89d9-c3064c4946cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_304f0c07-8561-4e54-b3b0-6e1b16c5e027" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_304f0c07-8561-4e54-b3b0-6e1b16c5e027" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_fe61fd54-a7ce-4d6f-80d3-7b3f2be0574a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_fe61fd54-a7ce-4d6f-80d3-7b3f2be0574a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_8a46a359-79b8-4a8e-a01d-a4d17c37e926" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_8a46a359-79b8-4a8e-a01d-a4d17c37e926" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable_d438116d-d2a5-40a1-a2d6-f54d0b054bfe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable_d438116d-d2a5-40a1-a2d6-f54d0b054bfe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_473a0a87-956f-4042-8edc-1db39fe16950" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_AssetImpairmentCharges_473a0a87-956f-4042-8edc-1db39fe16950" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_7270c1ad-e4d2-4211-85dc-166f701bdb5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_NetIncomeLoss_7270c1ad-e4d2-4211-85dc-166f701bdb5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_fb248932-ec99-4a6f-8793-6022fa3e9e43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_ShareBasedCompensation_fb248932-ec99-4a6f-8793-6022fa3e9e43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_892d9122-35b5-4bf7-9c1f-2c8da649b665" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_DepreciationAndAmortization_892d9122-35b5-4bf7-9c1f-2c8da649b665" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_15d9ae48-e4a5-4272-b159-24e89ebc702d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_15d9ae48-e4a5-4272-b159-24e89ebc702d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_076891c0-0c14-4ffb-a739-67a1617d3c90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_076891c0-0c14-4ffb-a739-67a1617d3c90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_8ab74fcd-d839-44ba-9d8c-a71d7991747c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_8ab74fcd-d839-44ba-9d8c-a71d7991747c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_49058a64-4c6a-48c1-8004-029fbecc77e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_49058a64-4c6a-48c1-8004-029fbecc77e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentInProcess_b91f8e6d-c41e-411c-8ac0-06ccdb3841b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentInProcess"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_ResearchAndDevelopmentInProcess_b91f8e6d-c41e-411c-8ac0-06ccdb3841b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_984cb3a7-cb56-483f-b9f1-1862dc720081" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f1b3232a-838d-4567-8620-ff8b0d9a3862" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_984cb3a7-cb56-483f-b9f1-1862dc720081" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e4491f2b-597b-4766-8f13-75cc6c7b00d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_024c1ee0-e627-4dbb-928c-0501ca55cb65" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e4491f2b-597b-4766-8f13-75cc6c7b00d7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_024c1ee0-e627-4dbb-928c-0501ca55cb65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a759a565-dae7-484e-8b11-7466fe69e295" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e4491f2b-597b-4766-8f13-75cc6c7b00d7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a759a565-dae7-484e-8b11-7466fe69e295" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_12c8c195-1229-4171-b67f-8b25bbcde6fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e4491f2b-597b-4766-8f13-75cc6c7b00d7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_12c8c195-1229-4171-b67f-8b25bbcde6fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a3acd431-89ff-478e-990f-5eae7a622986" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e4491f2b-597b-4766-8f13-75cc6c7b00d7" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a3acd431-89ff-478e-990f-5eae7a622986" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ff4ce464-47ff-4e7c-9d81-33b38f43a0fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfOtherLongTermDebt_6dc5c6b9-cc02-4eba-9832-8a150370b1d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfOtherLongTermDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ff4ce464-47ff-4e7c-9d81-33b38f43a0fc" xlink:to="loc_us-gaap_RepaymentsOfOtherLongTermDebt_6dc5c6b9-cc02-4eba-9832-8a150370b1d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSeniorDebt_3b794de8-60fb-4a2c-92be-038ea9be9461" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfSeniorDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ff4ce464-47ff-4e7c-9d81-33b38f43a0fc" xlink:to="loc_us-gaap_RepaymentsOfSeniorDebt_3b794de8-60fb-4a2c-92be-038ea9be9461" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AdequateProtectionPayments_9bb07377-d32a-40bb-b714-26dd2c3b03f6" xlink:href="endp-20230331.xsd#endp_AdequateProtectionPayments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ff4ce464-47ff-4e7c-9d81-33b38f43a0fc" xlink:to="loc_endp_AdequateProtectionPayments_9bb07377-d32a-40bb-b714-26dd2c3b03f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_75f7fcbb-4e05-452e-a584-d8350c9974b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ff4ce464-47ff-4e7c-9d81-33b38f43a0fc" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_75f7fcbb-4e05-452e-a584-d8350c9974b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfNotesPayable_a6e8510b-b819-4e10-9293-1f7352d11f00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfNotesPayable"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ff4ce464-47ff-4e7c-9d81-33b38f43a0fc" xlink:to="loc_us-gaap_RepaymentsOfNotesPayable_a6e8510b-b819-4e10-9293-1f7352d11f00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_9e7a62db-f8cc-4ce8-9e51-0be2d04c80a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ff4ce464-47ff-4e7c-9d81-33b38f43a0fc" xlink:to="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_9e7a62db-f8cc-4ce8-9e51-0be2d04c80a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2d1b53a3-fd93-4265-abaa-11bbac8db1d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_3a6f5088-c9bc-40b2-8d28-19d24bdc7556" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2d1b53a3-fd93-4265-abaa-11bbac8db1d5" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_3a6f5088-c9bc-40b2-8d28-19d24bdc7556" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ProceedsFromUSGovernmentAgreement_e52473cc-304d-45ed-bd56-ea6299eef27d" xlink:href="endp-20230331.xsd#endp_ProceedsFromUSGovernmentAgreement"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2d1b53a3-fd93-4265-abaa-11bbac8db1d5" xlink:to="loc_endp_ProceedsFromUSGovernmentAgreement_e52473cc-304d-45ed-bd56-ea6299eef27d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired_6163a55e-c78d-4ae4-ac80-31b2c0b7fb92" xlink:href="endp-20230331.xsd#endp_PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2d1b53a3-fd93-4265-abaa-11bbac8db1d5" xlink:to="loc_endp_PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired_6163a55e-c78d-4ae4-ac80-31b2c0b7fb92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidCapitalized_86f3fbab-6a90-44e1-ba94-3cd049b4ea9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestPaidCapitalized"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2d1b53a3-fd93-4265-abaa-11bbac8db1d5" xlink:to="loc_us-gaap_InterestPaidCapitalized_86f3fbab-6a90-44e1-ba94-3cd049b4ea9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_5ad1a586-a509-4d17-a02c-54fb4ef00483" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2d1b53a3-fd93-4265-abaa-11bbac8db1d5" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_5ad1a586-a509-4d17-a02c-54fb4ef00483" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToFundLongtermLoansToRelatedParties_f758c9ce-7294-464e-b97a-1c93e693eb94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToFundLongtermLoansToRelatedParties"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2d1b53a3-fd93-4265-abaa-11bbac8db1d5" xlink:to="loc_us-gaap_PaymentsToFundLongtermLoansToRelatedParties_f758c9ce-7294-464e-b97a-1c93e693eb94" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/BANKRUPTCYPROCEEDINGSLiabilitiesSubjecttoCompromiseDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#BANKRUPTCYPROCEEDINGSLiabilitiesSubjecttoCompromiseDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/BANKRUPTCYPROCEEDINGSLiabilitiesSubjecttoCompromiseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesSubjectToCompromise_865e3610-4dfc-48fd-8492-8a187aa122d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesSubjectToCompromise"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LiabilitiesSubjectToCompromiseLegalSettlementAccrual_579115e8-d720-47e8-914d-374f94c3917c" xlink:href="endp-20230331.xsd#endp_LiabilitiesSubjectToCompromiseLegalSettlementAccrual"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesSubjectToCompromise_865e3610-4dfc-48fd-8492-8a187aa122d8" xlink:to="loc_endp_LiabilitiesSubjectToCompromiseLegalSettlementAccrual_579115e8-d720-47e8-914d-374f94c3917c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LiabilitiesSubjectToCompromiseAccruedInterest_7722e81e-8234-4f83-ab71-c117f11cdc24" xlink:href="endp-20230331.xsd#endp_LiabilitiesSubjectToCompromiseAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesSubjectToCompromise_865e3610-4dfc-48fd-8492-8a187aa122d8" xlink:to="loc_endp_LiabilitiesSubjectToCompromiseAccruedInterest_7722e81e-8234-4f83-ab71-c117f11cdc24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LiabilitiesSubjectToCompromiseUncertainTaxPositions_fd1d1a55-477d-4103-bcc1-2d849ce92122" xlink:href="endp-20230331.xsd#endp_LiabilitiesSubjectToCompromiseUncertainTaxPositions"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesSubjectToCompromise_865e3610-4dfc-48fd-8492-8a187aa122d8" xlink:to="loc_endp_LiabilitiesSubjectToCompromiseUncertainTaxPositions_fd1d1a55-477d-4103-bcc1-2d849ce92122" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesSubjectToCompromiseOtherLiabilities_48fc9ff6-5b5e-473e-9f4b-4c597bf89db3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesSubjectToCompromiseOtherLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesSubjectToCompromise_865e3610-4dfc-48fd-8492-8a187aa122d8" xlink:to="loc_us-gaap_LiabilitiesSubjectToCompromiseOtherLiabilities_48fc9ff6-5b5e-473e-9f4b-4c597bf89db3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesSubjectToCompromiseDebtAndAccruedInterest_c4d742be-36d8-4d1a-ae9e-b4af7363177b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesSubjectToCompromiseDebtAndAccruedInterest"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesSubjectToCompromise_865e3610-4dfc-48fd-8492-8a187aa122d8" xlink:to="loc_us-gaap_LiabilitiesSubjectToCompromiseDebtAndAccruedInterest_c4d742be-36d8-4d1a-ae9e-b4af7363177b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LiabilitiesSubjectToCompromiseAccountsPayable_a2e0c5f5-4886-40cc-a1c0-058b5c202da1" xlink:href="endp-20230331.xsd#endp_LiabilitiesSubjectToCompromiseAccountsPayable"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesSubjectToCompromise_865e3610-4dfc-48fd-8492-8a187aa122d8" xlink:to="loc_endp_LiabilitiesSubjectToCompromiseAccountsPayable_a2e0c5f5-4886-40cc-a1c0-058b5c202da1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/BANKRUPTCYPROCEEDINGSReorganizationItemsDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#BANKRUPTCYPROCEEDINGSReorganizationItemsDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/BANKRUPTCYPROCEEDINGSReorganizationItemsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReorganizationItems_a15039f2-a559-43ed-a8c7-88300957f416" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReorganizationItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtorReorganizationItemsLegalAndAdvisoryProfessionalFees_e972e9f3-3888-448d-a137-e76529a4d35a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtorReorganizationItemsLegalAndAdvisoryProfessionalFees"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ReorganizationItems_a15039f2-a559-43ed-a8c7-88300957f416" xlink:to="loc_us-gaap_DebtorReorganizationItemsLegalAndAdvisoryProfessionalFees_e972e9f3-3888-448d-a137-e76529a4d35a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DISCONTINUEDOPERATIONSANDASSETSSALESAstoraDiscontinuedOperationsDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#DISCONTINUEDOPERATIONSANDASSETSSALESAstoraDiscontinuedOperationsDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/DISCONTINUEDOPERATIONSANDASSETSSALESAstoraDiscontinuedOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_f907993e-a3ce-4ad9-9067-b97a740aed79" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax_70bf8c8e-b33c-4af2-8efa-54493fe0358b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_f907993e-a3ce-4ad9-9067-b97a740aed79" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax_70bf8c8e-b33c-4af2-8efa-54493fe0358b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_95a09b38-cd92-4edf-8436-c9ca494ae0e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_f907993e-a3ce-4ad9-9067-b97a740aed79" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_95a09b38-cd92-4edf-8436-c9ca494ae0e8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/RESTRUCTURINGPretaxNetChargesDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#RESTRUCTURINGPretaxNetChargesDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/RESTRUCTURINGPretaxNetChargesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostsAndAssetImpairmentCharges_ba62fcff-dcca-4ac6-855b-947a41bfb025" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostsAndAssetImpairmentCharges"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeveranceCosts1_430ab02b-0930-4609-92c1-3c8ff3f2c634" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeveranceCosts1"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_RestructuringCostsAndAssetImpairmentCharges_ba62fcff-dcca-4ac6-855b-947a41bfb025" xlink:to="loc_us-gaap_SeveranceCosts1_430ab02b-0930-4609-92c1-3c8ff3f2c634" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringCosts_8daebab6-1f3a-4be8-a317-d80aa1a68ddd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherRestructuringCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_RestructuringCostsAndAssetImpairmentCharges_ba62fcff-dcca-4ac6-855b-947a41bfb025" xlink:to="loc_us-gaap_OtherRestructuringCosts_8daebab6-1f3a-4be8-a317-d80aa1a68ddd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestructuringAndRelatedCostInventoryAdjustments_fc86ba56-72a0-48ff-a647-ce4482261ce2" xlink:href="endp-20230331.xsd#endp_RestructuringAndRelatedCostInventoryAdjustments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_RestructuringCostsAndAssetImpairmentCharges_ba62fcff-dcca-4ac6-855b-947a41bfb025" xlink:to="loc_endp_RestructuringAndRelatedCostInventoryAdjustments_fc86ba56-72a0-48ff-a647-ce4482261ce2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_c549782e-17e3-43a3-8382-e199d04f600f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringReserveAcceleratedDepreciation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_RestructuringCostsAndAssetImpairmentCharges_ba62fcff-dcca-4ac6-855b-947a41bfb025" xlink:to="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_c549782e-17e3-43a3-8382-e199d04f600f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/FAIRVALUEMEASUREMENTSRestrictedCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#FAIRVALUEMEASUREMENTSRestrictedCashandCashEquivalentsDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/FAIRVALUEMEASUREMENTSRestrictedCashandCashEquivalentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_31944b33-2c3d-4442-a997-78145b8280f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_5b4b963e-4998-4ef7-a250-e824e9393329" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalents_31944b33-2c3d-4442-a997-78145b8280f0" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_5b4b963e-4998-4ef7-a250-e824e9393329" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_7d04f446-092c-4a64-b538-19ee856e2bb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalents_31944b33-2c3d-4442-a997-78145b8280f0" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_7d04f446-092c-4a64-b538-19ee856e2bb9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/INVENTORIESScheduleofInventoryDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#INVENTORIESScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/INVENTORIESScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_b2b4a497-80d7-45db-80ac-40c2f22f5667" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_b9ed000b-5429-4d67-8df6-0ef5eaa710f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b2b4a497-80d7-45db-80ac-40c2f22f5667" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_b9ed000b-5429-4d67-8df6-0ef5eaa710f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_29361292-007b-422c-a5b5-0c097a2e72af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b2b4a497-80d7-45db-80ac-40c2f22f5667" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_29361292-007b-422c-a5b5-0c097a2e72af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_afe6eaed-7920-4e39-bba5-b9305ff0b4fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b2b4a497-80d7-45db-80ac-40c2f22f5667" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_afe6eaed-7920-4e39-bba5-b9305ff0b4fb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/LEASESAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#LEASESAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/LEASESAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_endp_LeaseRightofUseAsset_1cc21c16-36f4-4eb6-a49e-77e7055c0d92" xlink:href="endp-20230331.xsd#endp_LeaseRightofUseAsset"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_92ecdbd3-b70c-4c4d-b30e-571758cc744c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_endp_LeaseRightofUseAsset_1cc21c16-36f4-4eb6-a49e-77e7055c0d92" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_92ecdbd3-b70c-4c4d-b30e-571758cc744c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_db3d4100-ea38-4e2c-ac29-b942a9e44b7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_endp_LeaseRightofUseAsset_1cc21c16-36f4-4eb6-a49e-77e7055c0d92" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_db3d4100-ea38-4e2c-ac29-b942a9e44b7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_18db0a46-d8d6-4982-b464-222e087683f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_7beb9e9c-f3f3-4186-b3ea-db50aa48cbb2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiability_18db0a46-d8d6-4982-b464-222e087683f3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_7beb9e9c-f3f3-4186-b3ea-db50aa48cbb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_c17b92d7-5dfb-4339-a80e-f77b555d258e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiability_18db0a46-d8d6-4982-b464-222e087683f3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_c17b92d7-5dfb-4339-a80e-f77b555d258e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_6757942d-d38d-4afe-b92f-321df2fca686" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_53c8ef89-f33d-4562-85e6-11807c67ee5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_6757942d-d38d-4afe-b92f-321df2fca686" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_53c8ef89-f33d-4562-85e6-11807c67ee5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_f29c2ead-39bb-441f-84e3-d4e236205e73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_6757942d-d38d-4afe-b92f-321df2fca686" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_f29c2ead-39bb-441f-84e3-d4e236205e73" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLESOtherIntangibleAssetsDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#GOODWILLANDOTHERINTANGIBLESOtherIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLESOtherIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a4611b44-62df-41a4-a596-af09d26dbc07" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_20dd0256-3095-4520-84c0-e1035510fd95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a4611b44-62df-41a4-a596-af09d26dbc07" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_20dd0256-3095-4520-84c0-e1035510fd95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_c09028f1-2326-4906-9306-a2133a9a34af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a4611b44-62df-41a4-a596-af09d26dbc07" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_c09028f1-2326-4906-9306-a2133a9a34af" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ACCOUNTSPAYABLEANDACCRUEDEXPENSESScheduleofAccountsPayableandAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#ACCOUNTSPAYABLEANDACCRUEDEXPENSESScheduleofAccountsPayableandAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/ACCOUNTSPAYABLEANDACCRUEDEXPENSESScheduleofAccountsPayableandAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent_14892ac0-3168-4148-b615-ef39bb1aa023" xlink:href="endp-20230331.xsd#endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent_14892ac0-3168-4148-b615-ef39bb1aa023" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_0bbfac3e-368e-4b48-870e-0f5c0c2c4412" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedEmployeeBenefitsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_us-gaap_AccruedEmployeeBenefitsCurrent_0bbfac3e-368e-4b48-870e-0f5c0c2c4412" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedLiabilitiesOtherSalesDeductionsCurrent_463aa7d3-3602-4d08-81e1-c6412f992d47" xlink:href="endp-20230331.xsd#endp_AccruedLiabilitiesOtherSalesDeductionsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_endp_AccruedLiabilitiesOtherSalesDeductionsCurrent_463aa7d3-3602-4d08-81e1-c6412f992d47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedLiabilitiesChargebacksCurrent_85043341-ee68-498a-ba63-5ec5b39c4b63" xlink:href="endp-20230331.xsd#endp_AccruedLiabilitiesChargebacksCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_endp_AccruedLiabilitiesChargebacksCurrent_85043341-ee68-498a-ba63-5ec5b39c4b63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedLiabilitiesRebatesCurrent_951d24c6-263c-43cb-a3b9-205ce8198407" xlink:href="endp-20230331.xsd#endp_AccruedLiabilitiesRebatesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_endp_AccruedLiabilitiesRebatesCurrent_951d24c6-263c-43cb-a3b9-205ce8198407" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedLiabilitiesReturnsAndAllowancesCurrent_273f3ee5-996c-43ab-b36c-e3e112e4da62" xlink:href="endp-20230331.xsd#endp_AccruedLiabilitiesReturnsAndAllowancesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_endp_AccruedLiabilitiesReturnsAndAllowancesCurrent_273f3ee5-996c-43ab-b36c-e3e112e4da62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_a02610e6-6c56-4ec2-9eda-549fa7618006" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_a02610e6-6c56-4ec2-9eda-549fa7618006" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_98ac09e9-df52-48fb-897f-1e4471aa52d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_us-gaap_InterestPayableCurrent_98ac09e9-df52-48fb-897f-1e4471aa52d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_9aad0bb4-7382-4a32-ae73-136e35fb286f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_bfafc8f9-f961-4276-9fc2-b5ada36ec745" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_9aad0bb4-7382-4a32-ae73-136e35fb286f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/OTHERINCOMEEXPENSENETScheduleofComponentsofOtherExpenseNetDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#OTHERINCOMEEXPENSENETScheduleofComponentsofOtherExpenseNetDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/OTHERINCOMEEXPENSENETScheduleofComponentsofOtherExpenseNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_04e1e57f-40bc-41df-855d-9b9d9b4f2dad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_GainLossDispositionOfBusinessAndOtherAssets_1f42c2d0-0fa4-4587-84d0-567e8522abb3" xlink:href="endp-20230331.xsd#endp_GainLossDispositionOfBusinessAndOtherAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_04e1e57f-40bc-41df-855d-9b9d9b4f2dad" xlink:to="loc_endp_GainLossDispositionOfBusinessAndOtherAssets_1f42c2d0-0fa4-4587-84d0-567e8522abb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_f6ccd4ce-5b89-4819-8c19-e1b7a4702bfc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_04e1e57f-40bc-41df-855d-9b9d9b4f2dad" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_f6ccd4ce-5b89-4819-8c19-e1b7a4702bfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_e4bf5ea7-b7c1-449b-b9ae-eb623072e424" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_04e1e57f-40bc-41df-855d-9b9d9b4f2dad" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_e4bf5ea7-b7c1-449b-b9ae-eb623072e424" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_001c0fd1-e026-4d4a-87ff-8a4f1162f689" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_04e1e57f-40bc-41df-855d-9b9d9b4f2dad" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_001c0fd1-e026-4d4a-87ff-8a4f1162f689" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/NETLOSSPERSHAREReconciliationoftheNumeratorandDenominatorofBasicandDilutedNetLossIncomePerShareDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#NETLOSSPERSHAREReconciliationoftheNumeratorandDenominatorofBasicandDilutedNetLossIncomePerShareDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/NETLOSSPERSHAREReconciliationoftheNumeratorandDenominatorofBasicandDilutedNetLossIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_df364bd1-d96c-43b6-a7c7-246df8db4211" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_bbfbe922-6f85-4c93-8026-57bd3739528c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_df364bd1-d96c-43b6-a7c7-246df8db4211" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_bbfbe922-6f85-4c93-8026-57bd3739528c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_195dc3e8-f7f9-4d2d-9e57-753fe393a7ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_df364bd1-d96c-43b6-a7c7-246df8db4211" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_195dc3e8-f7f9-4d2d-9e57-753fe393a7ee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFOPERATIONSDetails" xlink:type="simple" xlink:href="endp-20230331.xsd#CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFOPERATIONSDetails"/>
  <link:calculationLink xlink:role="http://www.endo.com/role/CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFOPERATIONSDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_endp_IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsIncomeTaxesNoncontrollingInterestNetOfTax_461546ea-e8e5-44f9-ba16-93c8a0ce67e5" xlink:href="endp-20230331.xsd#endp_IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsIncomeTaxesNoncontrollingInterestNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_a4f754da-a363-4555-b20f-ecd1f6fe1448" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_endp_IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsIncomeTaxesNoncontrollingInterestNetOfTax_461546ea-e8e5-44f9-ba16-93c8a0ce67e5" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_a4f754da-a363-4555-b20f-ecd1f6fe1448" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_2fbdd587-3427-4650-9ca4-56f1bfb8dce3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_endp_IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsIncomeTaxesNoncontrollingInterestNetOfTax_461546ea-e8e5-44f9-ba16-93c8a0ce67e5" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_2fbdd587-3427-4650-9ca4-56f1bfb8dce3" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
