

<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<xsd:schema attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.endo.com/20190630" xmlns:endp="http://www.endo.com/20190630" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsd="http://www.w3.org/2001/XMLSchema">
  <xsd:import namespace="http://fasb.org/srt-types/2019-01-31" schemaLocation="http://xbrl.fasb.org/srt/2019/elts/srt-types-2019-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2019-01-31" schemaLocation="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/us-gaap/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/us-roles/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-roles-2019-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/us-types/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-types-2019-01-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/country/2017-01-31" schemaLocation="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/currency/2019-01-31" schemaLocation="https://xbrl.sec.gov/currency/2019/currency-2019-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/dei/2019-01-31" schemaLocation="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/exch/2019-01-31" schemaLocation="https://xbrl.sec.gov/exch/2019/exch-2019-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/naics/2017-01-31" schemaLocation="http://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/stpr/2018-01-31" schemaLocation="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd" />
  <xsd:annotation>
    <xsd:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="endp-20190630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="endp-20190630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="endp-20190630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="endp-20190630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple" />
      <link:roleType id="AccountsPayableAndAccruedExpenses" roleURI="http://www.endo.com/role/AccountsPayableAndAccruedExpenses">
        <link:definition>2114100 - Disclosure - Accounts Payable And Accrued Expenses</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccountsPayableAndAccruedExpensesDetails" roleURI="http://www.endo.com/role/AccountsPayableAndAccruedExpensesDetails">
        <link:definition>2414402 - Disclosure - Accounts Payable And Accrued Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccountsPayableAndAccruedExpensesTables" roleURI="http://www.endo.com/role/AccountsPayableAndAccruedExpensesTables">
        <link:definition>2314301 - Disclosure - Accounts Payable And Accrued Expenses (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisOfPresentation" roleURI="http://www.endo.com/role/BasisOfPresentation">
        <link:definition>2101100 - Disclosure - Basis of Presentation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingencies" roleURI="http://www.endo.com/role/CommitmentsAndContingencies">
        <link:definition>2116100 - Disclosure - Commitments And Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingenciesNarrativeDetails" roleURI="http://www.endo.com/role/CommitmentsAndContingenciesNarrativeDetails">
        <link:definition>2416402 - Disclosure - Commitments And Contingencies (Narrative) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingenciesScheduleOfLossContingenciesDetails" roleURI="http://www.endo.com/role/CommitmentsAndContingenciesScheduleOfLossContingenciesDetails">
        <link:definition>2416403 - Disclosure - Commitments And Contingencies - Schedule of Loss Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingenciesTables" roleURI="http://www.endo.com/role/CommitmentsAndContingenciesTables">
        <link:definition>2316301 - Disclosure - Commitments And Contingencies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheetsParenthetical" roleURI="http://www.endo.com/role/CondensedConsolidatedBalanceSheetsParenthetical">
        <link:definition>1001501 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheetsUnaudited" roleURI="http://www.endo.com/role/CondensedConsolidatedBalanceSheetsUnaudited">
        <link:definition>1001000 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsOfCashFlowsUnaudited" roleURI="http://www.endo.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited">
        <link:definition>1006000 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsOfComprehensiveLossUnaudited" roleURI="http://www.endo.com/role/CondensedConsolidatedStatementsOfComprehensiveLossUnaudited">
        <link:definition>1003000 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsOfOperationsUnaudited" roleURI="http://www.endo.com/role/CondensedConsolidatedStatementsOfOperationsUnaudited">
        <link:definition>1002000 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ContractAssetsAndLiabilities" roleURI="http://www.endo.com/role/ContractAssetsAndLiabilities">
        <link:definition>2113100 - Disclosure - Contract Assets and Liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ContractAssetsAndLiabilitiesContractAssetsAndContractLiabilitiesFromContractsWithCustomersDetails" roleURI="http://www.endo.com/role/ContractAssetsAndLiabilitiesContractAssetsAndContractLiabilitiesFromContractsWithCustomersDetails">
        <link:definition>2413402 - Disclosure - Contract Assets and Liabilities - Contract Assets and Contract Liabilities from Contracts with Customers (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ContractAssetsAndLiabilitiesNarrativeDetails" roleURI="http://www.endo.com/role/ContractAssetsAndLiabilitiesNarrativeDetails">
        <link:definition>2413403 - Disclosure - Contract Assets and Liabilities - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ContractAssetsAndLiabilitiesTables" roleURI="http://www.endo.com/role/ContractAssetsAndLiabilitiesTables">
        <link:definition>2313301 - Disclosure - Contract Assets and Liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CoverPage" roleURI="http://www.endo.com/role/CoverPage">
        <link:definition>0001000 - Document - Cover Page</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Debt" roleURI="http://www.endo.com/role/Debt">
        <link:definition>2115100 - Disclosure - Debt</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtComponentsOfTotalIndebtednessDetails" roleURI="http://www.endo.com/role/DebtComponentsOfTotalIndebtednessDetails">
        <link:definition>2415402 - Disclosure - Debt (Components of Total Indebtedness) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtCreditFacilityNarrativeDetails" roleURI="http://www.endo.com/role/DebtCreditFacilityNarrativeDetails">
        <link:definition>2415403 - Disclosure - Debt (Credit Facility) (Narrative) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtMarch2019RefinancingDetails" roleURI="http://www.endo.com/role/DebtMarch2019RefinancingDetails">
        <link:definition>2415404 - Disclosure - Debt (March 2019 Refinancing) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtMaturitiesOnLongTermDebtForEachOfNextFiveYearsDetails" roleURI="http://www.endo.com/role/DebtMaturitiesOnLongTermDebtForEachOfNextFiveYearsDetails">
        <link:definition>2415405 - Disclosure - Debt (Maturities on Long-Term Debt for Each of The Next Five Years) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtTables" roleURI="http://www.endo.com/role/DebtTables">
        <link:definition>2315301 - Disclosure - Debt (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DiscontinuedOperations" roleURI="http://www.endo.com/role/DiscontinuedOperations">
        <link:definition>2103100 - Disclosure - Discontinued Operations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DiscontinuedOperationsAstoraDiscontinuedOperationsDetails" roleURI="http://www.endo.com/role/DiscontinuedOperationsAstoraDiscontinuedOperationsDetails">
        <link:definition>2403403 - Disclosure - Discontinued Operations - Astora - Discontinued Operations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DiscontinuedOperationsAstoraNarrativeDetails" roleURI="http://www.endo.com/role/DiscontinuedOperationsAstoraNarrativeDetails">
        <link:definition>2403404 - Disclosure - Discontinued Operations - Astora (Narrative) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DiscontinuedOperationsTables" roleURI="http://www.endo.com/role/DiscontinuedOperationsTables">
        <link:definition>2303301 - Disclosure - Discontinued Operations (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurements" roleURI="http://www.endo.com/role/FairValueMeasurements">
        <link:definition>2107100 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails" roleURI="http://www.endo.com/role/FairValueMeasurementsFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails">
        <link:definition>2407404 - Disclosure - Fair Value Measurements - Financial Assets And Liabilities Measured At Fair Value On Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsFinancialLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingSignificantUnobservableInputsDetails" roleURI="http://www.endo.com/role/FairValueMeasurementsFinancialLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingSignificantUnobservableInputsDetails">
        <link:definition>2407405 - Disclosure - Fair Value Measurements - Financial Liabilities Measured At Fair Value On Recurring Basis Using Significant Unobservable Inputs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsNarrativeDetails" roleURI="http://www.endo.com/role/FairValueMeasurementsNarrativeDetails">
        <link:definition>2407403 - Disclosure - Fair Value Measurements (Narrative) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsRestrictedCashAndCashEquivalentsDetails" roleURI="http://www.endo.com/role/FairValueMeasurementsRestrictedCashAndCashEquivalentsDetails">
        <link:definition>2407402 - Disclosure - Fair Value Measurements - Restricted Cash and Cash Equivalents (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsScheduleOfFinancialAssetsMeasuredAtFairValueOnNonrecurringBasisDetails" roleURI="http://www.endo.com/role/FairValueMeasurementsScheduleOfFinancialAssetsMeasuredAtFairValueOnNonrecurringBasisDetails">
        <link:definition>2407406 - Disclosure - - Fair Value Measurements (Schedule of Financial Assets Measured At Fair Value On A Nonrecurring Basis) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsTables" roleURI="http://www.endo.com/role/FairValueMeasurementsTables">
        <link:definition>2307301 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangibles" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangibles">
        <link:definition>2110100 - Disclosure - Goodwill and Other Intangibles</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangiblesAccumulatedImpairmentDetails" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangiblesAccumulatedImpairmentDetails">
        <link:definition>2410403 - Disclosure - Goodwill and Other Intangibles - Accumulated Impairment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangiblesImpairmentsNarrativeDetails" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangiblesImpairmentsNarrativeDetails">
        <link:definition>2410409 - Disclosure - Goodwill and Other Intangibles - Impairments Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangiblesOtherIntangiblesNarrativeDetails" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangiblesOtherIntangiblesNarrativeDetails">
        <link:definition>2410405 - Disclosure - Goodwill and Other Intangibles - Other Intangibles (Narrative) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangiblesScheduleOfChangesInCarryingAmountOfGoodwillDetails" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangiblesScheduleOfChangesInCarryingAmountOfGoodwillDetails">
        <link:definition>2410402 - Disclosure - Goodwill and Other Intangibles - Schedule of Changes in the Carrying Amount of Goodwill (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangiblesScheduleOfEstimatedAmortizationOfIntangiblesDetails" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangiblesScheduleOfEstimatedAmortizationOfIntangiblesDetails">
        <link:definition>2410407 - Disclosure - Goodwill and Other Intangibles - Schedule of Estimated Amortization of Intangibles (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangiblesScheduleOfIntangibleAssetImpairmentChargesIncludingGoodwillDetails" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangiblesScheduleOfIntangibleAssetImpairmentChargesIncludingGoodwillDetails">
        <link:definition>2410408 - Disclosure - Goodwill and Other Intangibles - Schedule of Intangible Asset Impairment Charges Including Goodwill (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangiblesScheduleOfOtherIntangibleAssetsDetails" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangiblesScheduleOfOtherIntangibleAssetsDetails">
        <link:definition>2410404 - Disclosure - Goodwill and Other Intangibles - Schedule of Other Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillAndOtherIntangiblesTables" roleURI="http://www.endo.com/role/GoodwillAndOtherIntangiblesTables">
        <link:definition>2310301 - Disclosure - Goodwill and Other Intangibles (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://www.endo.com/role/IncomeTaxes">
        <link:definition>2127100 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesScheduleOfComponentsOfContinuingOperationsBeforeIncomeTaxIncomeTaxExpenseEffectiveTaxRateDetails" roleURI="http://www.endo.com/role/IncomeTaxesScheduleOfComponentsOfContinuingOperationsBeforeIncomeTaxIncomeTaxExpenseEffectiveTaxRateDetails">
        <link:definition>2427411 - Disclosure - Income Taxes (Schedule of Components of Continuing Operations Before Income Tax, Income Tax Expense, Effective Tax Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesTables" roleURI="http://www.endo.com/role/IncomeTaxesTables">
        <link:definition>2327301 - Disclosure - Income Taxes (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Inventories" roleURI="http://www.endo.com/role/Inventories">
        <link:definition>2108100 - Disclosure - Inventories</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InventoriesDetails" roleURI="http://www.endo.com/role/InventoriesDetails">
        <link:definition>2408402 - Disclosure - Inventories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InventoriesTables" roleURI="http://www.endo.com/role/InventoriesTables">
        <link:definition>2308301 - Disclosure - Inventories (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Leases" roleURI="http://www.endo.com/role/Leases">
        <link:definition>2108100 - Disclosure - Leases</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesAssetsAndLiabilitiesDetails" roleURI="http://www.endo.com/role/LeasesAssetsAndLiabilitiesDetails">
        <link:definition>2408403 - Disclosure - Leases - Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesCashFlowAndSupplementalNoncashInformationDetails" roleURI="http://www.endo.com/role/LeasesCashFlowAndSupplementalNoncashInformationDetails">
        <link:definition>2408408 - Disclosure - Leases - Cash Flow and Supplemental Noncash Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesComponentsOfLeaseExpenseDetails" roleURI="http://www.endo.com/role/LeasesComponentsOfLeaseExpenseDetails">
        <link:definition>2408404 - Disclosure - Leases - Components of Lease Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesFutureMinimumLeasePaymentObligationsUnderOperatingAndCapitalLeasesDetails" roleURI="http://www.endo.com/role/LeasesFutureMinimumLeasePaymentObligationsUnderOperatingAndCapitalLeasesDetails">
        <link:definition>2408406 - Disclosure - Leases - Future Minimum Lease Payment Obligations Under Operating and Capital Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesFutureMinimumLeasePaymentObligationsUnderOperatingAndCapitalLeasesDetailsCalc2" roleURI="http://www.endo.com/role/LeasesFutureMinimumLeasePaymentObligationsUnderOperatingAndCapitalLeasesDetailsCalc2">
        <link:definition>2408406 - Disclosure - Leases - Future Minimum Lease Payment Obligations Under Operating and Capital Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesMaturitiesOfOperatingAndFinanceLeaseLiabilitiesDetails" roleURI="http://www.endo.com/role/LeasesMaturitiesOfOperatingAndFinanceLeaseLiabilitiesDetails">
        <link:definition>2408405 - Disclosure - Leases - Maturities of Operating and Finance Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesMaturitiesOfOperatingAndFinanceLeaseLiabilitiesDetailsCalc2" roleURI="http://www.endo.com/role/LeasesMaturitiesOfOperatingAndFinanceLeaseLiabilitiesDetailsCalc2">
        <link:definition>2408405 - Disclosure - Leases - Maturities of Operating and Finance Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesNarrativeDetails" roleURI="http://www.endo.com/role/LeasesNarrativeDetails">
        <link:definition>2408402 - Disclosure - Leases - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesTables" roleURI="http://www.endo.com/role/LeasesTables">
        <link:definition>2308301 - Disclosure - Leases (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesWeightedAverageTermLeaseAndDiscountRatesDetails" roleURI="http://www.endo.com/role/LeasesWeightedAverageTermLeaseAndDiscountRatesDetails">
        <link:definition>2408407 - Disclosure - Leases - Weighted Average Term Lease and Discount Rates (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetLossPerShare" roleURI="http://www.endo.com/role/NetLossPerShare">
        <link:definition>2128100 - Disclosure - Net Loss Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetLossPerShareReconciliationOfNumeratorAndDenominatorOfBasicAndDilutedNetLossPerShareDetails" roleURI="http://www.endo.com/role/NetLossPerShareReconciliationOfNumeratorAndDenominatorOfBasicAndDilutedNetLossPerShareDetails">
        <link:definition>2428402 - Disclosure - Net Loss Per Share (Reconciliation Of The Numerator And Denominator Of Basic And Diluted Net Loss Per Share) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetLossPerShareTables" roleURI="http://www.endo.com/role/NetLossPerShareTables">
        <link:definition>2328301 - Disclosure - Net Loss Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherComprehensiveIncomeLoss" roleURI="http://www.endo.com/role/OtherComprehensiveIncomeLoss">
        <link:definition>2117100 - Disclosure - Other Comprehensive Income (Loss)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherComprehensiveLossNarrativeDetails" roleURI="http://www.endo.com/role/OtherComprehensiveLossNarrativeDetails">
        <link:definition>2417403 - Disclosure - Other Comprehensive Loss - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherIncomeExpenseNet" roleURI="http://www.endo.com/role/OtherIncomeExpenseNet">
        <link:definition>2123100 - Disclosure - Other (Income) Expense, Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherIncomeExpenseNetDetails" roleURI="http://www.endo.com/role/OtherIncomeExpenseNetDetails">
        <link:definition>2423402 - Disclosure - Other (Income) Expense, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherIncomeExpenseNetTables" roleURI="http://www.endo.com/role/OtherIncomeExpenseNetTables">
        <link:definition>2323301 - Disclosure - Other (Income) Expense, Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Restructuring" roleURI="http://www.endo.com/role/Restructuring">
        <link:definition>2104100 - Disclosure - Restructuring</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Restructuring2017RestructuringInitiativesNarrativeDetails" roleURI="http://www.endo.com/role/Restructuring2017RestructuringInitiativesNarrativeDetails">
        <link:definition>2404403 - Disclosure - Restructuring - 2017 Restructuring Initiatives (Narrative) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringJanuary2018RestructuringInitiativeNarrativeDetails" roleURI="http://www.endo.com/role/RestructuringJanuary2018RestructuringInitiativeNarrativeDetails">
        <link:definition>2404406 - Disclosure - Restructuring - January 2018 Restructuring Initiative (Narrative) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringScheduleOfRestructuringRollForwardDetails" roleURI="http://www.endo.com/role/RestructuringScheduleOfRestructuringRollForwardDetails">
        <link:definition>2404405 - Disclosure - Restructuring - Schedule of Restructuring Roll Forward (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringTables" roleURI="http://www.endo.com/role/RestructuringTables">
        <link:definition>2304301 - Disclosure - Restructuring (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentResults" roleURI="http://www.endo.com/role/SegmentResults">
        <link:definition>2106100 - Disclosure - Segment Results</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentResultsScheduleOfDisaggregationOfRevenuesDetails" roleURI="http://www.endo.com/role/SegmentResultsScheduleOfDisaggregationOfRevenuesDetails">
        <link:definition>2406405 - Disclosure - Segment Results - Schedule of Disaggregation of Revenues (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentResultsScheduleOfReconciliationsOfConsolidatedAdjustedIncomeLossBeforeIncomeTaxDetails" roleURI="http://www.endo.com/role/SegmentResultsScheduleOfReconciliationsOfConsolidatedAdjustedIncomeLossBeforeIncomeTaxDetails">
        <link:definition>2406403 - Disclosure - Segment Results - Schedule of Reconciliations of Consolidated Adjusted Income (Loss) Before Income Tax (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentResultsScheduleOfReportableSegmentsInformationDetails" roleURI="http://www.endo.com/role/SegmentResultsScheduleOfReportableSegmentsInformationDetails">
        <link:definition>2406402 - Disclosure - Segment Results - Schedule of Reportable Segments Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentResultsTables" roleURI="http://www.endo.com/role/SegmentResultsTables">
        <link:definition>2306301 - Disclosure - Segment Results (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ShareholdersDeficit" roleURI="http://www.endo.com/role/ShareholdersDeficit">
        <link:definition>2119100 - Disclosure - Shareholders' Deficit</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ShareholdersDeficitEquityNarrativeDetails" roleURI="http://www.endo.com/role/ShareholdersDeficitEquityNarrativeDetails">
        <link:definition>2419405 - Disclosure - Shareholders' (Deficit) Equity (Narrative) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ShareholdersDeficitScheduleOfChangesInShareholdersEquityDetails" roleURI="http://www.endo.com/role/ShareholdersDeficitScheduleOfChangesInShareholdersEquityDetails">
        <link:definition>2419402 - Disclosure - Shareholders' Deficit - Schedule of Changes in Shareholders' Equity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ShareholdersDeficitTables" roleURI="http://www.endo.com/role/ShareholdersDeficitTables">
        <link:definition>2319301 - Disclosure - Shareholders' Deficit (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryOfSignificantAccountingPolicies" roleURI="http://www.endo.com/role/SummaryOfSignificantAccountingPolicies">
        <link:definition>2102100 - Disclosure - Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryOfSignificantAccountingPoliciesNarrativeDetails" roleURI="http://www.endo.com/role/SummaryOfSignificantAccountingPoliciesNarrativeDetails">
        <link:definition>2402402 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryOfSignificantAccountingPoliciesPolicies" roleURI="http://www.endo.com/role/SummaryOfSignificantAccountingPoliciesPolicies">
        <link:definition>2202201 - Disclosure - Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element abstract="true" id="endp_A2017CreditAgreementMember" name="A2017CreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_A6.00SeniorNotesDue2025Member" name="A6.00SeniorNotesDue2025Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_AcceleratedDepreciationMember" name="AcceleratedDepreciationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_AccruedLiabilitiesChargebacks" name="AccruedLiabilitiesChargebacks" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="endp_AccruedLiabilitiesRebates" name="AccruedLiabilitiesRebates" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="endp_AccruedLiabilitiesReturnsAndAllowances" name="AccruedLiabilitiesReturnsAndAllowances" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent" name="AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="endp_AcquisitionRelatedContingentConsiderationLongTermMember" name="AcquisitionRelatedContingentConsiderationLongTermMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_AcquisitionRelatedContingentConsiderationMember" name="AcquisitionRelatedContingentConsiderationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_AcquisitionRelatedContingentConsiderationShortTermMember" name="AcquisitionRelatedContingentConsiderationShortTermMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_AdjustedIncomeLossBeforeIncomeTax" name="AdjustedIncomeLossBeforeIncomeTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_AdrenalinMember" name="AdrenalinMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_AmericanMedicalSystemsMember" name="AmericanMedicalSystemsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_AndroGel1.62Member" name="AndroGel1.62Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_AssetImpairmentChargesIncludingContinuingandDiscontinuedOperations" name="AssetImpairmentChargesIncludingContinuingandDiscontinuedOperations" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_AssetsAndLiabilitiesLesseeTableTextBlock" name="AssetsAndLiabilitiesLesseeTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_AstoraMember" name="AstoraMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_AuxiliumPharmaceuticalsInc.Member" name="AuxiliumPharmaceuticalsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_Bierv.EndoInternationalplcetal.Member" name="Bierv.EndoInternationalplcetal.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_BrandedSpecialtyandEstablishedPharmaceuticalsMember" name="BrandedSpecialtyandEstablishedPharmaceuticalsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_BrandedSterileInjectablesMember" name="BrandedSterileInjectablesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_CashFlowLesseeAbstract" name="CashFlowLesseeAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ColchicineTabletsMember" name="ColchicineTabletsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_ContractwithCustomerAssetIncreaseDecreasePercentage" name="ContractwithCustomerAssetIncreaseDecreasePercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_ContractwithCustomerLiabilityIncreaseDecrease" name="ContractwithCustomerLiabilityIncreaseDecrease" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="endp_ContractwithCustomerLiabilityIncreaseDecreasePercentage" name="ContractwithCustomerLiabilityIncreaseDecreasePercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_CostReductionInitiatives" name="CostReductionInitiatives" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_CurrentandFormerDirectorsandOfficersMember" name="CurrentandFormerDirectorsandOfficersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_DebtInstrumentCommitmentsNotExtendedAmount" name="DebtInstrumentCommitmentsNotExtendedAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="endp_DebtInstrumentFaceAmountExcludingCurrentMaturities" name="DebtInstrumentFaceAmountExcludingCurrentMaturities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="endp_DebtInstrumentRedemptionPercentOfPrincipalAmountOutstanding" name="DebtInstrumentRedemptionPercentOfPrincipalAmountOutstanding" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_DebtInstrumentSecuredLeverageRatio" name="DebtInstrumentSecuredLeverageRatio" nillable="true" substitutionGroup="xbrli:item" type="xbrli:pureItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="endp_EmployeeSeparationRetentionandOtherBenefitRelatedCostsMember" name="EmployeeSeparationRetentionandOtherBenefitRelatedCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_EmployeeSeverenceandOtherBenefitRelatedCostsMember" name="EmployeeSeverenceandOtherBenefitRelatedCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ErtapenemForInjectionMember" name="ErtapenemForInjectionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_EstablishedProductsMember" name="EstablishedProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_EuroDeferredSharesMember" name="EuroDeferredSharesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_EuroDeferredSharesParorStatedValuePerShare" name="EuroDeferredSharesParorStatedValuePerShare" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_EuroDeferredSharesSharesAuthorized" name="EuroDeferredSharesSharesAuthorized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_EuroDeferredSharesSharesIssued" name="EuroDeferredSharesSharesIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_EuroDeferredStockValueIssued" name="EuroDeferredStockValueIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="endp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward" name="FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_FiniteLivedIntangibleAssetsOther" name="FiniteLivedIntangibleAssetsOther" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_FiniteLivedIntangibleAssetsOtherAdjustmentsIncreaseDecreaseInAccumulatedAmortization" name="FiniteLivedIntangibleAssetsOtherAdjustmentsIncreaseDecreaseInAccumulatedAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="endp_FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization" name="FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember" name="FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember" name="FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_FivePointThreeSevenFiveSeniorNotesDueOnTwoThousandTwentyThreeMember" name="FivePointThreeSevenFiveSeniorNotesDueOnTwoThousandTwentyThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_FormerU.S.GenericPharmaceuticalsMember" name="FormerU.S.GenericPharmaceuticalsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_GenericPharmaceuticalsMember" name="GenericPharmaceuticalsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_HostingArrangementServiceContractPolicyTextBlock" name="HostingArrangementServiceContractPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_HuntsvilleAlabamaManufacturingandDistributingFacilityMember" name="HuntsvilleAlabamaManufacturingandDistributingFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_ImpairmentofIntangibleAssetsFinitelivedEffectOnAccumulatedAmortization" name="ImpairmentofIntangibleAssetsFinitelivedEffectOnAccumulatedAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_IndefinitelivedIntangibleAssetsOther" name="IndefinitelivedIntangibleAssetsOther" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_IntangibleAssetsAcquired" name="IntangibleAssetsAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_IntangibleAssetsExcludingGoodwillFairValueDisclosure" name="IntangibleAssetsExcludingGoodwillFairValueDisclosure" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="endp_IntangibleAssetsForeignCurrencyTranslationGainLoss" name="IntangibleAssetsForeignCurrencyTranslationGainLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_IntangibleAssetsGrossRollForward" name="IntangibleAssetsGrossRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_IntangibleAssetsMember" name="IntangibleAssetsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput" name="IntangibleAssetsNetIncludingGoodwillMeasurementInput" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_IntangibleAssetsOther" name="IntangibleAssetsOther" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_InternationalPharmaceuticalsMember" name="InternationalPharmaceuticalsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_InventoryNotYetAvailableForSaleNet" name="InventoryNotYetAvailableForSaleNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="endp_InventoryStepUp" name="InventoryStepUp" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_InventoryWriteOffsMember" name="InventoryWriteOffsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_January2018RestructuringMember" name="January2018RestructuringMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LeaseRightofUseAsset" name="LeaseRightofUseAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="endp_LehighValleyTechnologiesInc.Member" name="LehighValleyTechnologiesInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LesseeOperatingLeaseNumberOfRenewalOptions" name="LesseeOperatingLeaseNumberOfRenewalOptions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_LidodermMember" name="LidodermMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LongtermDebtMaturityRepaymentDeadline" name="LongtermDebtMaturityRepaymentDeadline" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyAccrualPaymentsToPlaintiffCounsel" name="LossContingencyAccrualPaymentsToPlaintiffCounsel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" name="LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyCasesSetForTrialNumber" name="LossContingencyCasesSetForTrialNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyClaimsFiledByStatesNumber" name="LossContingencyClaimsFiledByStatesNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_LossContingencyExtensionofTemporaryStayNumberofDays" name="LossContingencyExtensionofTemporaryStayNumberofDays" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyLawsuitFilingPeriod" name="LossContingencyLawsuitFilingPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyLengthOfTrialNumberOfDays" name="LossContingencyLengthOfTrialNumberOfDays" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyNumberOfAdditionalDefendantsNamed" name="LossContingencyNumberOfAdditionalDefendantsNamed" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" name="LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty" name="LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_LossContingencyNumberOfDefendantsFilingMotionToDismiss" name="LossContingencyNumberOfDefendantsFilingMotionToDismiss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyNumberOfDefendantsFilingMotionToDismissBreachofContractClaim" name="LossContingencyNumberOfDefendantsFilingMotionToDismissBreachofContractClaim" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyNumberOfDefendantsFilingMotionToDismissLackOfPersonalInjuryJurisdiction" name="LossContingencyNumberOfDefendantsFilingMotionToDismissLackOfPersonalInjuryJurisdiction" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyNumberOfPutativeClassActions" name="LossContingencyNumberOfPutativeClassActions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyNumberofConsultants" name="LossContingencyNumberofConsultants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyNumberofDaysforPlaintifftoFileNotice" name="LossContingencyNumberofDaysforPlaintifftoFileNotice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyStayOfApprovalPeriodHatchWaxmanAct" name="LossContingencyStayOfApprovalPeriodHatchWaxmanAct" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyStayOfProceedingsNumberOfDays" name="LossContingencyStayOfProceedingsNumberOfDays" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_NonVestedRestrictedStockMember" name="NonVestedRestrictedStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_NonVestedStockOptionsMember" name="NonVestedStockOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_NoteRepurchasesMember" name="NoteRepurchasesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_NumberofCausationTheories" name="NumberofCausationTheories" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_NumberofCausationTheoriesRejected" name="NumberofCausationTheoriesRejected" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OpioidRelatedMattersMember" name="OpioidRelatedMattersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherAcquisitionsMember" name="OtherAcquisitionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherEstablishedProductsMember" name="OtherEstablishedProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherIntangibleAssetsCostBasisAbstract" name="OtherIntangibleAssetsCostBasisAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherIntangibleAssetsLineItems" name="OtherIntangibleAssetsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_OtherPaymentsForLegalSettlements" name="OtherPaymentsForLegalSettlements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherSpecialtyProductsMember" name="OtherSpecialtyProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherSterileInjectablesMember" name="OtherSterileInjectablesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_PERCOCETMember" name="PERCOCETMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ParPharmaceuticalInc.Member" name="ParPharmaceuticalInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts" name="PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_PerformanceStockUnitsMember" name="PerformanceStockUnitsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ProductLiabilityMember" name="ProductLiabilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_ProductLineRevenueReportingThreshold" name="ProductLineRevenueReportingThreshold" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_PropertyPlantandEquipmentImpairmentChargesMember" name="PropertyPlantandEquipmentImpairmentChargesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_PublicEmployeesRetirementSystemofMississippivs.EndoInternationalPLCMember" name="PublicEmployeesRetirementSystemofMississippivs.EndoInternationalPLCMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_RestrictedCashAndCashEquivalentsMember" name="RestrictedCashAndCashEquivalentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_RightofUseAssetObtainedInExchangeForLeaseLiabilityAbstract" name="RightofUseAssetObtainedInExchangeForLeaseLiabilityAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SUPPRELINLAMember" name="SUPPRELINLAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ScheduleOfGoodwillAndOtherIntangiblesTable" name="ScheduleOfGoodwillAndOtherIntangiblesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock" name="ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_SegmentReportingInformationUnallocatedCorporateExpense" name="SegmentReportingInformationUnallocatedCorporateExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SeniorNotesMaturingDue2022Member" name="SeniorNotesMaturingDue2022Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_SettlementFunds" name="SettlementFunds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="endp_SettlementFundsAdditions" name="SettlementFundsAdditions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_SettlementFundsOther" name="SettlementFundsOther" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_SettlementFundsPayments" name="SettlementFundsPayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="endp_SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" name="SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SettlementFundsRollForward" name="SettlementFundsRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember" name="SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember" name="SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsAwardedinPeriodNotYetGranted" name="SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsAwardedinPeriodNotYetGranted" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember" name="SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SterileInjectablesMember" name="SterileInjectablesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_TermLoanBFacilityDueTwoThousandTwentyFourMember" name="TermLoanBFacilityDueTwoThousandTwentyFourMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_TestopelMember" name="TestopelMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_TestosteroneCasesMember" name="TestosteroneCasesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_TotalSpecialtyProductsMember" name="TotalSpecialtyProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_USGenericPharmaceuticalsRestructuring2017Member" name="USGenericPharmaceuticalsRestructuring2017Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_UpfrontAndMilestonePaymentsToPartners" name="UpfrontAndMilestonePaymentsToPartners" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_VASOSTRICTRelatedMattersMember" name="VASOSTRICTRelatedMattersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_VaginalMeshCasesMember" name="VaginalMeshCasesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_VasostrictMember" name="VasostrictMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_VoltarenGelMember" name="VoltarenGelMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_XiaflexMember" name="XiaflexMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>





