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  <xs:element id="endp_LiabilitiesSubjectToCompromiseFinanceLeaseLiability" abstract="false" name="LiabilitiesSubjectToCompromiseFinanceLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization" abstract="false" name="FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_TLCAgreementMember" abstract="true" name="TLCAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_StockAwardMember" abstract="true" name="StockAwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_EuroDeferredSharesMember" abstract="true" name="EuroDeferredSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember" abstract="true" name="SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ContractwithCustomerLiabilityIncreaseDecrease" abstract="false" name="ContractwithCustomerLiabilityIncreaseDecrease" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyAccrualPaymentPeriod" abstract="false" name="LossContingencyAccrualPaymentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_OpiodClaimantsMember" abstract="true" name="OpiodClaimantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_AdequateProtectionPayments" abstract="false" name="AdequateProtectionPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsIncomeTaxesNoncontrollingInterestNetOfTax" abstract="false" name="IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsIncomeTaxesNoncontrollingInterestNetOfTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_RestructuringAndRelatedCostsExpectedCostSavings" abstract="false" name="RestructuringAndRelatedCostsExpectedCostSavings" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember" abstract="true" name="SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_SegmentReportingInformationUnallocatedCorporateExpense" abstract="false" name="SegmentReportingInformationUnallocatedCorporateExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AdrenalinMember" abstract="true" name="AdrenalinMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_VASOSTRICTRelatedMattersMember" abstract="true" name="VASOSTRICTRelatedMattersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ResolutionSettlementGrossConsiderationPayable" abstract="false" name="ResolutionSettlementGrossConsiderationPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_ProductLiabilityMember" abstract="true" name="ProductLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ScheduleOfLiabilitiesSubjectToCompromiseTableTextBlock" abstract="false" name="ScheduleOfLiabilitiesSubjectToCompromiseTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="endp_TermLoanFacilityMember" abstract="true" name="TermLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_RestructuringInitiativeApril2022Member" abstract="true" name="RestructuringInitiativeApril2022Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_VareniclineTabletsMember" abstract="true" name="VareniclineTabletsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseAccountsPayable" abstract="false" name="LiabilitiesSubjectToCompromiseAccountsPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SettlementFundsRollForward" abstract="true" name="SettlementFundsRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_SixPercentSeniorNotesDueTwoThousandTwentyFiveMember" abstract="true" name="SixPercentSeniorNotesDueTwoThousandTwentyFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LossContingencyClaimsFiledByStatesNumber" abstract="false" name="LossContingencyClaimsFiledByStatesNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_ParPharmaceuticalIncMember" abstract="true" name="ParPharmaceuticalIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LitigationSettlementSubsequentSettlementPayment" abstract="false" name="LitigationSettlementSubsequentSettlementPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_NovavaxIncMember" abstract="true" name="NovavaxIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_SterileInjectablesSegmentMember" abstract="true" name="SterileInjectablesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_SixPointOneTwoFivePercentSeniorNotesDueTwoThousandTwentyNineMember" abstract="true" name="SixPointOneTwoFivePercentSeniorNotesDueTwoThousandTwentyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_InidentifiableIntangibleAssetsMember" abstract="true" name="InidentifiableIntangibleAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_NevakarInjectablesIncMember" abstract="true" name="NevakarInjectablesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ContractwithCustomerLiabilityIncreaseDecreasePercentage" abstract="false" name="ContractwithCustomerLiabilityIncreaseDecreasePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="endp_SettlementFunds" abstract="false" name="SettlementFunds" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
