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  <xs:element id="endp_RanitidineMattersMember" abstract="true" name="RanitidineMattersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="endp_DebtInstrumentBasisSpreadOnVariableRateFloor" abstract="false" name="DebtInstrumentBasisSpreadOnVariableRateFloor" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="endp_LehighValleyTechnologiesInc.Member" abstract="true" name="LehighValleyTechnologiesInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="endp_PaymentsForProductAcquisitionCostsAndLicenseFees" abstract="false" name="PaymentsForProductAcquisitionCostsAndLicenseFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_InventoryNotYetAvailableForSaleNet" abstract="false" name="InventoryNotYetAvailableForSaleNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_DebtInstrumentCovenantPeriodBeforeMaturityDateToRepayDebtInstrument" abstract="false" name="DebtInstrumentCovenantPeriodBeforeMaturityDateToRepayDebtInstrument" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
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  <xs:element id="endp_SegmentReportingInformationUnallocatedCorporateExpense" abstract="false" name="SegmentReportingInformationUnallocatedCorporateExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_MeshRelatedCasesMember" abstract="true" name="MeshRelatedCasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember" abstract="true" name="FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock" abstract="false" name="ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="endp_ManufacturingFacilitiesInChestnutRidgeNYAndIrvineCAAndUSProductRegulatoryApprovalsAndCertainRelatedProductInventoryMember" abstract="true" name="ManufacturingFacilitiesInChestnutRidgeNYAndIrvineCAAndUSProductRegulatoryApprovalsAndCertainRelatedProductInventoryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="endp_SettlementFundsCashContributionsToQualifiedSettlementFunds" abstract="false" name="SettlementFundsCashContributionsToQualifiedSettlementFunds" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" abstract="false" name="LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="endp_AmericanMedicalSystemsMember" abstract="true" name="AmericanMedicalSystemsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion" abstract="false" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_VASOSTRICTandorADRENALINMember" abstract="true" name="VASOSTRICTandorADRENALINMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="endp_PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired" abstract="false" name="PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_AstoraMember" abstract="true" name="AstoraMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="endp_OtherPaymentsForLegalSettlements" abstract="false" name="OtherPaymentsForLegalSettlements" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_ScheduleOfGoodwillAndOtherIntangiblesTable" abstract="true" name="ScheduleOfGoodwillAndOtherIntangiblesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
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  <xs:element id="endp_ImpairmentofIntangibleAssetsFinitelivedEffectOnAccumulatedAmortization" abstract="false" name="ImpairmentofIntangibleAssetsFinitelivedEffectOnAccumulatedAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_ProductLineRevenueReportingThreshold" abstract="false" name="ProductLineRevenueReportingThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PelletierVEndoInternationalPlcMember" abstract="true" name="PelletierVEndoInternationalPlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_AssetsHeldForSaleNotPartOfDisposalGroupOtherIntangiblesNet" abstract="false" name="AssetsHeldForSaleNotPartOfDisposalGroupOtherIntangiblesNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_OtherEstablishedProductsMember" abstract="true" name="OtherEstablishedProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_EuroDeferredSharesMember" abstract="true" name="EuroDeferredSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" abstract="false" name="LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCharges" abstract="false" name="EmployeeSeparationContinuityAndOtherBenefitRelatedCharges" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DisposalGroupIncludingDiscontinuedOperationNonCashConsideration" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationNonCashConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AdjustedIncomeLossBeforeIncomeTax" abstract="false" name="AdjustedIncomeLossBeforeIncomeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DebtInstrumentCovenantTriggerMaximumPrincipalAmountOfDebtInstruments" abstract="false" name="DebtInstrumentCovenantTriggerMaximumPrincipalAmountOfDebtInstruments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AssetImpairmentChargesMember" abstract="true" name="AssetImpairmentChargesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_EuroDeferredStockValueIssued" abstract="false" name="EuroDeferredStockValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AssetImpairmentChargesIncludingContinuingandDiscontinuedOperations" abstract="false" name="AssetImpairmentChargesIncludingContinuingandDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DebtInstrumentExtendedMaturityModificationAmount" abstract="false" name="DebtInstrumentExtendedMaturityModificationAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_GainLossDispositionOfBusinessAndOtherAssets" abstract="false" name="GainLossDispositionOfBusinessAndOtherAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty" abstract="false" name="LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_LossContingencyPlaintiffsNumberOfStateCourtActionsRemovedToFederalCourt" abstract="false" name="LossContingencyPlaintiffsNumberOfStateCourtActionsRemovedToFederalCourt" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_RestructuringInitiative2020Member" abstract="true" name="RestructuringInitiative2020Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ContractWithCustomerPerformanceObligationSatisfactionPeriod" abstract="false" name="ContractWithCustomerPerformanceObligationSatisfactionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_EconomicDamagesMember" abstract="true" name="EconomicDamagesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_SterileInjectablesSegmentMember" abstract="true" name="SterileInjectablesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LeaseRightofUseAsset" abstract="false" name="LeaseRightofUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput" abstract="false" name="IntangibleAssetsNetIncludingGoodwillMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="endp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation" abstract="false" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AssetsHeldForSaleNotPartOfDisposalGroupComponentsOfAssetsAndLiabilitiesTableTextBlock" abstract="false" name="AssetsHeldForSaleNotPartOfDisposalGroupComponentsOfAssetsAndLiabilitiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="endp_LossContingencyPlaintiffsNumberOfStateCourtActions" abstract="false" name="LossContingencyPlaintiffsNumberOfStateCourtActions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_AdrenalinMember" abstract="true" name="AdrenalinMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LossContingencyNumberOfPutativeClassActions" abstract="false" name="LossContingencyNumberOfPutativeClassActions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_IntangibleAssetsOther" abstract="false" name="IntangibleAssetsOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts" abstract="false" name="PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
