<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:b3cfde92-fea3-415b-a443-8475efbc908c,g:8d59aa78-3199-458b-a233-357df034f984-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.endo.com/role/CoverPage" xlink:type="simple" xlink:href="endp-20210331.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_fd417638-e145-419b-8b11-7b14a317ea5c" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_DocumentType_fd417638-e145-419b-8b11-7b14a317ea5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_03231be9-7307-47bf-81b2-402c6d6442b8" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_DocumentQuarterlyReport_03231be9-7307-47bf-81b2-402c6d6442b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_8bcfae97-c66e-4c84-9fae-33d86781b7fa" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_DocumentPeriodEndDate_8bcfae97-c66e-4c84-9fae-33d86781b7fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_eb2737c6-9631-4e3b-a039-b3d451405f8d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_DocumentTransitionReport_eb2737c6-9631-4e3b-a039-b3d451405f8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_2e34e460-3a23-4f00-94a1-17d0fd4dd4f2" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityFileNumber_2e34e460-3a23-4f00-94a1-17d0fd4dd4f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_8cc3ea66-af24-4973-bd25-5c93a4fdcb86" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityRegistrantName_8cc3ea66-af24-4973-bd25-5c93a4fdcb86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_2160d067-80f3-4f87-81c2-febc34f1abfc" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityIncorporationStateCountryCode_2160d067-80f3-4f87-81c2-febc34f1abfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_cf4f8c97-2e75-439c-a5e1-5875f5e341e8" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityTaxIdentificationNumber_cf4f8c97-2e75-439c-a5e1-5875f5e341e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_aca29b94-5cbc-41d9-9b45-1c79a26ba508" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityAddressAddressLine1_aca29b94-5cbc-41d9-9b45-1c79a26ba508" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_23781215-dde6-4138-9433-c47fed7d61a6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityAddressCityOrTown_23781215-dde6-4138-9433-c47fed7d61a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCountry_6b74c4ae-2acf-4dc5-a05d-c20edb0bdc50" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCountry"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityAddressCountry_6b74c4ae-2acf-4dc5-a05d-c20edb0bdc50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_79eb0f3c-d1c9-4be9-abc3-c27d09266869" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityAddressPostalZipCode_79eb0f3c-d1c9-4be9-abc3-c27d09266869" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_306992f3-55f6-40c1-9ce7-b33cffe9e684" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_CityAreaCode_306992f3-55f6-40c1-9ce7-b33cffe9e684" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_7416a799-15bf-477b-98c3-4b460483615d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_LocalPhoneNumber_7416a799-15bf-477b-98c3-4b460483615d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_2423c623-b8de-4018-a49d-de47b84f9351" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityCurrentReportingStatus_2423c623-b8de-4018-a49d-de47b84f9351" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_ad9cf1c3-d686-4854-88c7-7ba8b5e1d4d7" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityInteractiveDataCurrent_ad9cf1c3-d686-4854-88c7-7ba8b5e1d4d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_9baac3e5-6668-43e4-ad0d-e1bd0cff8f01" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityFilerCategory_9baac3e5-6668-43e4-ad0d-e1bd0cff8f01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_6f8bf0a8-cbc1-44f0-b049-990996d89253" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntitySmallBusiness_6f8bf0a8-cbc1-44f0-b049-990996d89253" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_f5f8348d-63fe-44bf-b9f4-a04210c4da73" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityEmergingGrowthCompany_f5f8348d-63fe-44bf-b9f4-a04210c4da73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_007cc6c9-14e6-4c22-a1b4-e7aa2715ad62" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityShellCompany_007cc6c9-14e6-4c22-a1b4-e7aa2715ad62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_0d2d9ee8-a133-4536-ab3e-4a02c8cb964d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_Security12bTitle_0d2d9ee8-a133-4536-ab3e-4a02c8cb964d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_a9625212-7db3-492e-a37e-e72ed259ca82" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_TradingSymbol_a9625212-7db3-492e-a37e-e72ed259ca82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_9404e5c8-e65a-4943-882b-c95c7a983a33" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_SecurityExchangeName_9404e5c8-e65a-4943-882b-c95c7a983a33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_4343d9ac-2e5c-4fb5-9e81-5e21b361c3cc" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_4343d9ac-2e5c-4fb5-9e81-5e21b361c3cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_1a74bf59-a9c6-463e-9902-c9b38aa400fc" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_AmendmentFlag_1a74bf59-a9c6-463e-9902-c9b38aa400fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_5783e103-4eb1-4fba-98f7-ba30cef031fc" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_DocumentFiscalYearFocus_5783e103-4eb1-4fba-98f7-ba30cef031fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_431c868e-9175-4ab6-94f7-a5ee77a9a2ee" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_DocumentFiscalPeriodFocus_431c868e-9175-4ab6-94f7-a5ee77a9a2ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_b66acb70-53df-4c1b-914f-730ede396d54" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_EntityCentralIndexKey_b66acb70-53df-4c1b-914f-730ede396d54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_b76ba390-0745-447e-90a0-c1d7b883fc9a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_e2f5fc63-e796-4fbf-81af-08ebeae82abb" xlink:to="loc_dei_CurrentFiscalYearEndDate_b76ba390-0745-447e-90a0-c1d7b883fc9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="simple" xlink:href="endp-20210331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_2cb08716-7c87-40cc-85ea-db5fc1f5bed8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_2cb08716-7c87-40cc-85ea-db5fc1f5bed8" xlink:to="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:to="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_19f9a3db-c8fc-4abf-8e93-82fee6168018" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_19f9a3db-c8fc-4abf-8e93-82fee6168018" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_2b6dba85-d7dd-4ed9-bbce-e016b7998553" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_2b6dba85-d7dd-4ed9-bbce-e016b7998553" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_dccfe043-17dc-4f7a-a581-468eb3e70bb3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_dccfe043-17dc-4f7a-a581-468eb3e70bb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_b8c89a9d-8060-41bb-bf43-a04c2052bae2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:to="loc_us-gaap_InventoryNet_b8c89a9d-8060-41bb-bf43-a04c2052bae2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_997c36f8-9ad4-4a0b-bc06-8f8b8e7d6f67" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_997c36f8-9ad4-4a0b-bc06-8f8b8e7d6f67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_20c5934f-21a4-403b-8b9f-57a6b35d4fbf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxesReceivable"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:to="loc_us-gaap_IncomeTaxesReceivable_20c5934f-21a4-403b-8b9f-57a6b35d4fbf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_8d661fe6-7314-4e32-85c4-f038e1c7f1f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_364b7ea8-e08f-4fc6-a137-b970e9c39398" xlink:to="loc_us-gaap_AssetsCurrent_8d661fe6-7314-4e32-85c4-f038e1c7f1f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_cdcdec10-6f20-44bf-b51e-4252cc176486" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_cdcdec10-6f20-44bf-b51e-4252cc176486" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_85551cef-a0b3-46f1-97e5-8336c00b2885" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_85551cef-a0b3-46f1-97e5-8336c00b2885" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_19e9fd36-7fec-40a5-ba71-487e7d749504" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:to="loc_us-gaap_Goodwill_19e9fd36-7fec-40a5-ba71-487e7d749504" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_c7247a92-6b29-4c06-a2d0-cd76586d12a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_c7247a92-6b29-4c06-a2d0-cd76586d12a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_593ac957-7ab1-4427-8064-3f16d0503f9c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_593ac957-7ab1-4427-8064-3f16d0503f9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_d752b173-177b-4a9f-b6b1-636e9373cbfe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_d752b173-177b-4a9f-b6b1-636e9373cbfe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_a098c88f-7f71-443c-a42b-dcbda0c9464f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_770d4872-61bb-454f-b4fc-01d04e13887f" xlink:to="loc_us-gaap_Assets_a098c88f-7f71-443c-a42b-dcbda0c9464f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_2cb08716-7c87-40cc-85ea-db5fc1f5bed8" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_94c1f1c5-87a2-43f0-9611-4796ef509aa8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_94c1f1c5-87a2-43f0-9611-4796ef509aa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_2cbc193a-2d25-4cd6-9e8b-6714b9e317ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94c1f1c5-87a2-43f0-9611-4796ef509aa8" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_2cbc193a-2d25-4cd6-9e8b-6714b9e317ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualCarryingValueCurrent_1fcb13b1-2e8a-4487-b32d-a43b9590a6da" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyAccrualCarryingValueCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94c1f1c5-87a2-43f0-9611-4796ef509aa8" xlink:to="loc_us-gaap_LossContingencyAccrualCarryingValueCurrent_1fcb13b1-2e8a-4487-b32d-a43b9590a6da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_13c79472-e5f7-432b-a7fa-3386f3ddf772" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94c1f1c5-87a2-43f0-9611-4796ef509aa8" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_13c79472-e5f7-432b-a7fa-3386f3ddf772" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_ef618509-e13f-4431-bbf0-bdceff637537" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94c1f1c5-87a2-43f0-9611-4796ef509aa8" xlink:to="loc_us-gaap_LongTermDebtCurrent_ef618509-e13f-4431-bbf0-bdceff637537" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_8166baf0-659e-4799-a11b-a14f9fc75d27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94c1f1c5-87a2-43f0-9611-4796ef509aa8" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_8166baf0-659e-4799-a11b-a14f9fc75d27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_7dcfa3fd-fced-4a0e-9180-bf5ef7e229d8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94c1f1c5-87a2-43f0-9611-4796ef509aa8" xlink:to="loc_us-gaap_LiabilitiesCurrent_7dcfa3fd-fced-4a0e-9180-bf5ef7e229d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_d9d42d6a-b4ac-48b4-b77d-ccd1c12171fc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_d9d42d6a-b4ac-48b4-b77d-ccd1c12171fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_73adc170-9ad0-4af8-a3a6-310855ebe6c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_73adc170-9ad0-4af8-a3a6-310855ebe6c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_9b3437be-b9bb-4dad-927c-dcba7565264c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_9b3437be-b9bb-4dad-927c-dcba7565264c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_4b8b5865-c3a7-411a-bb67-ccbdc723e01a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_4b8b5865-c3a7-411a-bb67-ccbdc723e01a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_cff8b9ad-a2c7-4e3b-bc24-0152f083a18f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:to="loc_us-gaap_CommitmentsAndContingencies_cff8b9ad-a2c7-4e3b-bc24-0152f083a18f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_fedd6d17-e4d9-49c3-8068-664a65066f5d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_fedd6d17-e4d9-49c3-8068-664a65066f5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EuroDeferredStockValueIssued_95ac0854-e467-450b-83b0-1e95ba957e42" xlink:href="endp-20210331.xsd#endp_EuroDeferredStockValueIssued"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_fedd6d17-e4d9-49c3-8068-664a65066f5d" xlink:to="loc_endp_EuroDeferredStockValueIssued_95ac0854-e467-450b-83b0-1e95ba957e42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_3fd998f4-9a96-4aae-ac73-a24fc13c2b12" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_fedd6d17-e4d9-49c3-8068-664a65066f5d" xlink:to="loc_us-gaap_CommonStockValue_3fd998f4-9a96-4aae-ac73-a24fc13c2b12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_31be3504-00ab-42c1-a21b-162851d317cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_fedd6d17-e4d9-49c3-8068-664a65066f5d" xlink:to="loc_us-gaap_AdditionalPaidInCapital_31be3504-00ab-42c1-a21b-162851d317cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d12e1e45-3387-4fd7-ae9b-1b67bc12c68c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_fedd6d17-e4d9-49c3-8068-664a65066f5d" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d12e1e45-3387-4fd7-ae9b-1b67bc12c68c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_27d65743-5a6f-4c05-9ff2-5e894c531aea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_fedd6d17-e4d9-49c3-8068-664a65066f5d" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_27d65743-5a6f-4c05-9ff2-5e894c531aea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_91221f3e-57ea-4d00-8f81-1b58a9cf1ec1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_fedd6d17-e4d9-49c3-8068-664a65066f5d" xlink:to="loc_us-gaap_StockholdersEquity_91221f3e-57ea-4d00-8f81-1b58a9cf1ec1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_50e1462d-b912-4ae5-be14-4a47f6d2191f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_60ef7e8c-9c4c-4c47-87d3-38b92141e079" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_50e1462d-b912-4ae5-be14-4a47f6d2191f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITEDParenthetical" xlink:type="simple" xlink:href="endp-20210331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITEDParenthetical"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITEDParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_e00a3576-4e1b-49b1-a70e-bc230a13f15b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_e00a3576-4e1b-49b1-a70e-bc230a13f15b" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EuroDeferredSharesParorStatedValuePerShare_9ad86c19-a445-4eec-8112-4d779e5aedac" xlink:href="endp-20210331.xsd#endp_EuroDeferredSharesParorStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:to="loc_endp_EuroDeferredSharesParorStatedValuePerShare_9ad86c19-a445-4eec-8112-4d779e5aedac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EuroDeferredSharesSharesAuthorized_3da88421-8c44-4aa8-b83a-3e1e3dc93df1" xlink:href="endp-20210331.xsd#endp_EuroDeferredSharesSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:to="loc_endp_EuroDeferredSharesSharesAuthorized_3da88421-8c44-4aa8-b83a-3e1e3dc93df1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EuroDeferredSharesSharesIssued_58bda62c-de42-435b-ba74-fe47c2ac96e1" xlink:href="endp-20210331.xsd#endp_EuroDeferredSharesSharesIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:to="loc_endp_EuroDeferredSharesSharesIssued_58bda62c-de42-435b-ba74-fe47c2ac96e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_bd0777a3-954c-4ea6-aebd-62a18986b68f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_bd0777a3-954c-4ea6-aebd-62a18986b68f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_03edf99f-c59c-4b4d-b8c7-e44cdd872d55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_03edf99f-c59c-4b4d-b8c7-e44cdd872d55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_9a92684f-289d-4a19-b0a0-5123cc7284f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:to="loc_us-gaap_CommonStockSharesIssued_9a92684f-289d-4a19-b0a0-5123cc7284f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_719d2790-5370-435a-9b22-30867cdcafa8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_655a80cb-e79c-4558-8d8d-b8b0c9c3757d" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_719d2790-5370-435a-9b22-30867cdcafa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="simple" xlink:href="endp-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7bcd8bb7-5af1-4e13-88c0-201b6b160883" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7bcd8bb7-5af1-4e13-88c0-201b6b160883" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_c927a1e1-ace3-47fb-83e3-c0190a800c10" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_c927a1e1-ace3-47fb-83e3-c0190a800c10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_f9a89690-7eff-476a-9971-d92919b88279" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfRevenue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_c927a1e1-ace3-47fb-83e3-c0190a800c10" xlink:to="loc_us-gaap_CostOfRevenue_f9a89690-7eff-476a-9971-d92919b88279" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_025835de-2413-46a5-a104-a3e287d34d58" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_c927a1e1-ace3-47fb-83e3-c0190a800c10" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_025835de-2413-46a5-a104-a3e287d34d58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_61d4d981-645a-405c-a0a4-665b6ba7f06f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_c927a1e1-ace3-47fb-83e3-c0190a800c10" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_61d4d981-645a-405c-a0a4-665b6ba7f06f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_59c0cc9a-ec8f-4bbd-bc26-5700abccc7a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_c927a1e1-ace3-47fb-83e3-c0190a800c10" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_59c0cc9a-ec8f-4bbd-bc26-5700abccc7a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_e8bb1f0b-fe53-4ea0-afce-a39b803c7c0a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_c927a1e1-ace3-47fb-83e3-c0190a800c10" xlink:to="loc_us-gaap_AssetImpairmentCharges_e8bb1f0b-fe53-4ea0-afce-a39b803c7c0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_4e55bc46-e714-4267-8f15-405e8434c82f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_c927a1e1-ace3-47fb-83e3-c0190a800c10" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_4e55bc46-e714-4267-8f15-405e8434c82f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_911e4195-dafd-4098-a896-8e0e1555580d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_InterestExpense_911e4195-dafd-4098-a896-8e0e1555580d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_d8664f5d-a9e2-4190-9968-4250939ed2a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_d8664f5d-a9e2-4190-9968-4250939ed2a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_e56f68d4-0586-4517-a7c8-30e9922e8610" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_e56f68d4-0586-4517-a7c8-30e9922e8610" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_46457917-71d4-4076-9baa-28028597ae7f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_46457917-71d4-4076-9baa-28028597ae7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_4af30e19-ef26-4388-a7c6-6f6d34e5624f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_4af30e19-ef26-4388-a7c6-6f6d34e5624f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_cbcca664-4911-4df8-bf59-d8d306f6c082" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_cbcca664-4911-4df8-bf59-d8d306f6c082" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_c4a706c7-090e-4993-975e-e92a88d12438" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_c4a706c7-090e-4993-975e-e92a88d12438" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_58c22ab1-0d9d-46e5-8efa-62d8a943735c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_NetIncomeLoss_58c22ab1-0d9d-46e5-8efa-62d8a943735c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAbstract_00daf8f8-33f8-4001-a457-ca621a1714a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareBasicAbstract"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_EarningsPerShareBasicAbstract_00daf8f8-33f8-4001-a457-ca621a1714a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_d9118bc9-bd99-45e5-987e-378b89e7322b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_00daf8f8-33f8-4001-a457-ca621a1714a6" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_d9118bc9-bd99-45e5-987e-378b89e7322b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerBasicShare_891cca79-84aa-468b-b30b-529fbf4b4a63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerBasicShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_00daf8f8-33f8-4001-a457-ca621a1714a6" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerBasicShare_891cca79-84aa-468b-b30b-529fbf4b4a63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_a89d08dd-83ce-4a55-88ac-9fe756e104c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_00daf8f8-33f8-4001-a457-ca621a1714a6" xlink:to="loc_us-gaap_EarningsPerShareBasic_a89d08dd-83ce-4a55-88ac-9fe756e104c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDilutedAbstract_a38f695d-6b59-423e-9f46-9beb6771db6c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareDilutedAbstract"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_EarningsPerShareDilutedAbstract_a38f695d-6b59-423e-9f46-9beb6771db6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_b9204e08-94b9-4730-a1f3-c96cd53536ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_a38f695d-6b59-423e-9f46-9beb6771db6c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_b9204e08-94b9-4730-a1f3-c96cd53536ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerDilutedShare_9ad3e4f7-2699-43ad-bbf9-920c275c76e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerDilutedShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_a38f695d-6b59-423e-9f46-9beb6771db6c" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationNetOfTaxPerDilutedShare_9ad3e4f7-2699-43ad-bbf9-920c275c76e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_d337b348-4bd7-4944-8b88-3096b2ec10a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_a38f695d-6b59-423e-9f46-9beb6771db6c" xlink:to="loc_us-gaap_EarningsPerShareDiluted_d337b348-4bd7-4944-8b88-3096b2ec10a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_5746bfc1-3e43-4ce7-b1ed-3b2902f1952f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e23ced3c-da02-4bdd-948e-fdf1ac9715e3" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_5746bfc1-3e43-4ce7-b1ed-3b2902f1952f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_ad74ac53-c92f-4b4d-8095-328a4da7da67" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_5746bfc1-3e43-4ce7-b1ed-3b2902f1952f" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_ad74ac53-c92f-4b4d-8095-328a4da7da67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_28d5ba5f-f218-4042-a4b0-02ef2c8d69a1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_5746bfc1-3e43-4ce7-b1ed-3b2902f1952f" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_28d5ba5f-f218-4042-a4b0-02ef2c8d69a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSUNAUDITED" xlink:type="simple" xlink:href="endp-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSUNAUDITED"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_dd7053ce-d434-4b55-a97c-e69d7caebe25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f9249f90-9008-4e34-8b5c-99927d4df1cd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_dd7053ce-d434-4b55-a97c-e69d7caebe25" xlink:to="loc_us-gaap_NetIncomeLoss_f9249f90-9008-4e34-8b5c-99927d4df1cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_8c98ee40-5dc4-4cdd-9583-407f1f666252" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_dd7053ce-d434-4b55-a97c-e69d7caebe25" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_8c98ee40-5dc4-4cdd-9583-407f1f666252" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_774fc72e-f671-4321-9bb8-06adc1238294" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_8c98ee40-5dc4-4cdd-9583-407f1f666252" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_774fc72e-f671-4321-9bb8-06adc1238294" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_1d4b2547-4b67-40ee-b2fa-dc91be2570c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_8c98ee40-5dc4-4cdd-9583-407f1f666252" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_1d4b2547-4b67-40ee-b2fa-dc91be2570c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_5ca69090-0718-4a3f-a7c2-cc8742dfef2e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_8c98ee40-5dc4-4cdd-9583-407f1f666252" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_5ca69090-0718-4a3f-a7c2-cc8742dfef2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="simple" xlink:href="endp-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_06471142-80c5-4879-95fe-325e7459c693" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_06471142-80c5-4879-95fe-325e7459c693" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_ddbd9124-91b2-4aeb-9998-cde30272e604" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_06471142-80c5-4879-95fe-325e7459c693" xlink:to="loc_us-gaap_NetIncomeLoss_ddbd9124-91b2-4aeb-9998-cde30272e604" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_06471142-80c5-4879-95fe-325e7459c693" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_5cde93ce-330a-4707-bfd8-1d88a40a2338" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_us-gaap_DepreciationAndAmortization_5cde93ce-330a-4707-bfd8-1d88a40a2338" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_f4a1ef39-bb3c-4505-9b74-6cb7c10ee7a0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_us-gaap_ShareBasedCompensation_f4a1ef39-bb3c-4505-9b74-6cb7c10ee7a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_93c068e3-dd13-4308-bed5-4b4417e4bdb2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_93c068e3-dd13-4308-bed5-4b4417e4bdb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_c43a0bbe-b34f-4a4a-818c-726e963baea9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_c43a0bbe-b34f-4a4a-818c-726e963baea9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_1ca33317-c3fb-47ff-82ca-7087ee85e38d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_1ca33317-c3fb-47ff-82ca-7087ee85e38d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_bf670524-7f58-4770-9fcd-d1823620e281" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_bf670524-7f58-4770-9fcd-d1823620e281" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AssetImpairmentChargesIncludingContinuingandDiscontinuedOperations_39531e52-5fc2-47c5-83c0-3159ffadc6bd" xlink:href="endp-20210331.xsd#endp_AssetImpairmentChargesIncludingContinuingandDiscontinuedOperations"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_endp_AssetImpairmentChargesIncludingContinuingandDiscontinuedOperations_39531e52-5fc2-47c5-83c0-3159ffadc6bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_2aa26063-18f3-43b5-bbfd-fd80dfe05479" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_2aa26063-18f3-43b5-bbfd-fd80dfe05479" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_60bbbcae-4485-4fe1-8dad-da047ba68eb3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_91d902af-6272-461c-b92f-bc8b64cfc495" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_60bbbcae-4485-4fe1-8dad-da047ba68eb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_e12388d3-2b5b-48b4-a3af-fb55f4733441" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_60bbbcae-4485-4fe1-8dad-da047ba68eb3" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_e12388d3-2b5b-48b4-a3af-fb55f4733441" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_5ae633d5-8d18-46de-8ee5-25c8e75f3b4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_60bbbcae-4485-4fe1-8dad-da047ba68eb3" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_5ae633d5-8d18-46de-8ee5-25c8e75f3b4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_95333433-92f7-421f-b285-8e19ccb5dbb1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_60bbbcae-4485-4fe1-8dad-da047ba68eb3" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_95333433-92f7-421f-b285-8e19ccb5dbb1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_446281a1-a503-4139-9161-cb1bb1129280" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_60bbbcae-4485-4fe1-8dad-da047ba68eb3" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_446281a1-a503-4139-9161-cb1bb1129280" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable_5af2776e-a882-43b7-9d60-30b029ad42c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_60bbbcae-4485-4fe1-8dad-da047ba68eb3" xlink:to="loc_us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable_5af2776e-a882-43b7-9d60-30b029ad42c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_291bbbd1-6f85-4285-891a-95e45540def2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_06471142-80c5-4879-95fe-325e7459c693" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_291bbbd1-6f85-4285-891a-95e45540def2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1646d343-7282-4443-b459-28dc1701cfc5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1646d343-7282-4443-b459-28dc1701cfc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_143e316e-7835-4039-a32f-46c4a23f7213" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1646d343-7282-4443-b459-28dc1701cfc5" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_143e316e-7835-4039-a32f-46c4a23f7213" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidCapitalized_deea17cb-50cb-4fd3-85ef-e8a33245ac0d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestPaidCapitalized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1646d343-7282-4443-b459-28dc1701cfc5" xlink:to="loc_us-gaap_InterestPaidCapitalized_deea17cb-50cb-4fd3-85ef-e8a33245ac0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_6fb98b4b-cb0c-4f29-a868-eb0b595de68c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1646d343-7282-4443-b459-28dc1701cfc5" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_6fb98b4b-cb0c-4f29-a868-eb0b595de68c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_82cda5b0-bef7-4a01-84df-c0c0df831393" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1646d343-7282-4443-b459-28dc1701cfc5" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_82cda5b0-bef7-4a01-84df-c0c0df831393" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromNotesPayable_8a709199-81d6-4d15-8d0d-5afde664b1dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromNotesPayable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_us-gaap_ProceedsFromNotesPayable_8a709199-81d6-4d15-8d0d-5afde664b1dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt_83806f17-31e3-4799-baf5-034af8b465a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt_83806f17-31e3-4799-baf5-034af8b465a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfOtherLongTermDebt_a70d19d1-c91f-4436-b6fe-4460740f3710" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfOtherLongTermDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_us-gaap_RepaymentsOfOtherLongTermDebt_a70d19d1-c91f-4436-b6fe-4460740f3710" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_8703a9ab-5457-4bec-9cec-03081bfa22db" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_us-gaap_RepaymentsOfDebt_8703a9ab-5457-4bec-9cec-03081bfa22db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts_ad9af864-a1cc-4615-97d2-11dc97375348" xlink:href="endp-20210331.xsd#endp_PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_endp_PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts_ad9af864-a1cc-4615-97d2-11dc97375348" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_4abf95ef-67d9-4088-81fe-9aa85190fb60" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_4abf95ef-67d9-4088-81fe-9aa85190fb60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_98616271-08ff-4de3-a981-ac9a16204005" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_98616271-08ff-4de3-a981-ac9a16204005" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_0dc26199-a28a-497e-8c44-572b5567e7a1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_0dc26199-a28a-497e-8c44-572b5567e7a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_6b85989f-6277-4f33-9bc3-565aa8169037" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_7b62e9ff-9706-4161-b028-0c0c88576e18" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_6b85989f-6277-4f33-9bc3-565aa8169037" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_511a8027-4eb1-41c1-9814-683c132ee657" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_511a8027-4eb1-41c1-9814-683c132ee657" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0db4169a-5c2a-41f3-beac-f7a6710782d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0db4169a-5c2a-41f3-beac-f7a6710782d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4a7bd156-2ec6-48ce-a5c5-cd95f25bf1ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4a7bd156-2ec6-48ce-a5c5-cd95f25bf1ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a4c6aa63-be4c-4acb-9b33-c5e49a9f4a6e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a4c6aa63-be4c-4acb-9b33-c5e49a9f4a6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_da0726ac-9185-4cdd-b78a-932c9207ba64" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_50e8acba-07f0-4711-b94f-0ee1d7ddcfec" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_da0726ac-9185-4cdd-b78a-932c9207ba64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFundsAdditions_fca129eb-f811-4350-9e57-e9fd199b6996" xlink:href="endp-20210331.xsd#endp_SettlementFundsAdditions"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_da0726ac-9185-4cdd-b78a-932c9207ba64" xlink:to="loc_endp_SettlementFundsAdditions_fca129eb-f811-4350-9e57-e9fd199b6996" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFundsPayments_7d511a84-409a-4dad-ace7-5e922e2600bf" xlink:href="endp-20210331.xsd#endp_SettlementFundsPayments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_da0726ac-9185-4cdd-b78a-932c9207ba64" xlink:to="loc_endp_SettlementFundsPayments_7d511a84-409a-4dad-ace7-5e922e2600bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_OtherPaymentsForLegalSettlements_360813d5-09ad-4336-b5bf-ca385b9bb01b" xlink:href="endp-20210331.xsd#endp_OtherPaymentsForLegalSettlements"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_da0726ac-9185-4cdd-b78a-932c9207ba64" xlink:to="loc_endp_OtherPaymentsForLegalSettlements_360813d5-09ad-4336-b5bf-ca385b9bb01b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/BasisofPresentation" xlink:type="simple" xlink:href="endp-20210331.xsd#BasisofPresentation"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/BasisofPresentation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_added135-1353-4966-b5c2-53453d18c430" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_4c71ee9c-1d55-462e-8c7c-73f33e916f8a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_added135-1353-4966-b5c2-53453d18c430" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_4c71ee9c-1d55-462e-8c7c-73f33e916f8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="endp-20210331.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingChangesAndErrorCorrectionsAbstract_e1fa9fdd-b3c4-451b-8a2a-4a7117ede5ed" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountingChangesAndErrorCorrectionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_67298f92-d459-48a6-a103-974ecbcc01d6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingChangesAndErrorCorrectionsAbstract_e1fa9fdd-b3c4-451b-8a2a-4a7117ede5ed" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_67298f92-d459-48a6-a103-974ecbcc01d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="endp-20210331.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingChangesAndErrorCorrectionsAbstract_a9e21965-7605-49dd-a028-344805786364" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountingChangesAndErrorCorrectionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates_15efcb80-5df3-463f-ac4f-17e1cf845b11" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UseOfEstimates"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingChangesAndErrorCorrectionsAbstract_a9e21965-7605-49dd-a028-344805786364" xlink:to="loc_us-gaap_UseOfEstimates_15efcb80-5df3-463f-ac4f-17e1cf845b11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DiscontinuedOperations" xlink:type="simple" xlink:href="endp-20210331.xsd#DiscontinuedOperations"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DiscontinuedOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_c2fa05a3-7356-475d-9281-a8ac03f74797" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_f42e4b94-bb38-48fc-9c61-17c1f6a30784" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_c2fa05a3-7356-475d-9281-a8ac03f74797" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_f42e4b94-bb38-48fc-9c61-17c1f6a30784" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DiscontinuedOperationsTables" xlink:type="simple" xlink:href="endp-20210331.xsd#DiscontinuedOperationsTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DiscontinuedOperationsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_f0bb98f3-b205-4ebe-bb2d-82c15c11d2f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDisposalGroupsIncludingDiscontinuedOperationsIncomeStatementBalanceSheetAndAdditionalDisclosuresTextBlock_4e808fec-6c83-49f0-acd4-73ada7e1d10d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfDisposalGroupsIncludingDiscontinuedOperationsIncomeStatementBalanceSheetAndAdditionalDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_f0bb98f3-b205-4ebe-bb2d-82c15c11d2f6" xlink:to="loc_us-gaap_ScheduleOfDisposalGroupsIncludingDiscontinuedOperationsIncomeStatementBalanceSheetAndAdditionalDisclosuresTextBlock_4e808fec-6c83-49f0-acd4-73ada7e1d10d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DiscontinuedOperationsAstoraDiscontinuedOperationsDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#DiscontinuedOperationsAstoraDiscontinuedOperationsDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DiscontinuedOperationsAstoraDiscontinuedOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_68b153ef-9897-43ac-9491-dd7c3d0bdeaf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_81d610c8-aab4-47c9-b02b-4d4ce13bdb1c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_68b153ef-9897-43ac-9491-dd7c3d0bdeaf" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_81d610c8-aab4-47c9-b02b-4d4ce13bdb1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_cc7cb867-2b61-46ab-946f-b94b3b5b9182" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_81d610c8-aab4-47c9-b02b-4d4ce13bdb1c" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_cc7cb867-2b61-46ab-946f-b94b3b5b9182" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_3c47389c-00f1-441a-8691-b233b0651c4b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_cc7cb867-2b61-46ab-946f-b94b3b5b9182" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_3c47389c-00f1-441a-8691-b233b0651c4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_6f2a0fc0-4539-4725-8f79-97103803facf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_3c47389c-00f1-441a-8691-b233b0651c4b" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_6f2a0fc0-4539-4725-8f79-97103803facf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_17a83935-360e-449f-a5da-9a6623e72de7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_81d610c8-aab4-47c9-b02b-4d4ce13bdb1c" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_17a83935-360e-449f-a5da-9a6623e72de7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_373a2273-0c64-471c-be22-6b5e92773cf1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_17a83935-360e-449f-a5da-9a6623e72de7" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_373a2273-0c64-471c-be22-6b5e92773cf1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AstoraMember_c3445fd4-c395-4369-93ed-10ebb05600e0" xlink:href="endp-20210331.xsd#endp_AstoraMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_373a2273-0c64-471c-be22-6b5e92773cf1" xlink:to="loc_endp_AstoraMember_c3445fd4-c395-4369-93ed-10ebb05600e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_d174549b-5387-4858-9a65-6b21c15a6607" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_81d610c8-aab4-47c9-b02b-4d4ce13bdb1c" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_d174549b-5387-4858-9a65-6b21c15a6607" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_DisposalGroupIncludingDiscontinuedOperationLitigationRelatedAndOtherContingencies_982a390a-ef7e-4d1b-a886-dcf4987e58ac" xlink:href="endp-20210331.xsd#endp_DisposalGroupIncludingDiscontinuedOperationLitigationRelatedAndOtherContingencies"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_d174549b-5387-4858-9a65-6b21c15a6607" xlink:to="loc_endp_DisposalGroupIncludingDiscontinuedOperationLitigationRelatedAndOtherContingencies_982a390a-ef7e-4d1b-a886-dcf4987e58ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax_8ff4dc8b-2bd2-4258-8b1c-73e618b17746" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_d174549b-5387-4858-9a65-6b21c15a6607" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationBeforeIncomeTax_8ff4dc8b-2bd2-4258-8b1c-73e618b17746" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_98b05789-989a-49c4-916f-95a8f65496d3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_d174549b-5387-4858-9a65-6b21c15a6607" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfDiscontinuedOperation_98b05789-989a-49c4-916f-95a8f65496d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_7f387441-73b6-4bf7-a572-b10be1a69063" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_d174549b-5387-4858-9a65-6b21c15a6607" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_7f387441-73b6-4bf7-a572-b10be1a69063" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DiscontinuedOperationsAstoraNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#DiscontinuedOperationsAstoraNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DiscontinuedOperationsAstoraNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_98cde7e6-3d3e-4067-98e9-4e7094284ba9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_84d7bf95-c755-4004-b230-1603ef5dbbb3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_98cde7e6-3d3e-4067-98e9-4e7094284ba9" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_84d7bf95-c755-4004-b230-1603ef5dbbb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_274b033d-eeae-4491-9a5a-76981762bc60" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_84d7bf95-c755-4004-b230-1603ef5dbbb3" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_274b033d-eeae-4491-9a5a-76981762bc60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_f16f99fa-09ef-4593-b9a6-4316e1f14f14" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_274b033d-eeae-4491-9a5a-76981762bc60" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_f16f99fa-09ef-4593-b9a6-4316e1f14f14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_9ec07cf6-deff-40c1-8e2b-98f75ddccaf0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_f16f99fa-09ef-4593-b9a6-4316e1f14f14" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfByMeansOtherThanSaleAbandonmentMember_9ec07cf6-deff-40c1-8e2b-98f75ddccaf0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_e09e2c68-fc74-4b31-8500-0666c8cd4647" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_84d7bf95-c755-4004-b230-1603ef5dbbb3" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_e09e2c68-fc74-4b31-8500-0666c8cd4647" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_bf8c2f8a-7e98-472c-914f-25fd22579d75" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_e09e2c68-fc74-4b31-8500-0666c8cd4647" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_bf8c2f8a-7e98-472c-914f-25fd22579d75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AstoraMember_77b619c2-d218-43e3-8aac-f4b35e2fa408" xlink:href="endp-20210331.xsd#endp_AstoraMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_bf8c2f8a-7e98-472c-914f-25fd22579d75" xlink:to="loc_endp_AstoraMember_77b619c2-d218-43e3-8aac-f4b35e2fa408" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_fa7ff2bc-73db-4ded-80d8-5fb42d586aaf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_84d7bf95-c755-4004-b230-1603ef5dbbb3" xlink:to="loc_us-gaap_RestructuringCostAndReserveLineItems_fa7ff2bc-73db-4ded-80d8-5fb42d586aaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_b75948e1-2256-4330-a59d-8298f6baf42a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_fa7ff2bc-73db-4ded-80d8-5fb42d586aaf" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_b75948e1-2256-4330-a59d-8298f6baf42a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_da71e300-fbae-47af-959e-1a0bdc0f4aff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_fa7ff2bc-73db-4ded-80d8-5fb42d586aaf" xlink:to="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_da71e300-fbae-47af-959e-1a0bdc0f4aff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationDepreciationAndAmortization_ef22f483-f205-42a8-98bd-02b3c76d9fef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationDepreciationAndAmortization"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_fa7ff2bc-73db-4ded-80d8-5fb42d586aaf" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationDepreciationAndAmortization_ef22f483-f205-42a8-98bd-02b3c76d9fef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/Restructuring" xlink:type="simple" xlink:href="endp-20210331.xsd#Restructuring"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/Restructuring" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_ac60f130-d8d8-45a5-aba5-fb65aa313a29" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesDisclosureTextBlock_07d9a335-7900-4515-aa95-51c5d8d4dcbd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_ac60f130-d8d8-45a5-aba5-fb65aa313a29" xlink:to="loc_us-gaap_RestructuringAndRelatedActivitiesDisclosureTextBlock_07d9a335-7900-4515-aa95-51c5d8d4dcbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/RestructuringTables" xlink:type="simple" xlink:href="endp-20210331.xsd#RestructuringTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/RestructuringTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_f70cef7b-5df6-4e02-95f6-eaf6e8fe78b8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_4f42b3a3-1491-4969-b1cb-6031d651d052" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_f70cef7b-5df6-4e02-95f6-eaf6e8fe78b8" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_4f42b3a3-1491-4969-b1cb-6031d651d052" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringReserveByTypeOfCostTextBlock_4aaabc19-d086-464a-bda4-28f9ec540c81" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringReserveByTypeOfCostTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_f70cef7b-5df6-4e02-95f6-eaf6e8fe78b8" xlink:to="loc_us-gaap_ScheduleOfRestructuringReserveByTypeOfCostTextBlock_4aaabc19-d086-464a-bda4-28f9ec540c81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/Restructuring2020RestructuringInitiativeNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#Restructuring2020RestructuringInitiativeNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/Restructuring2020RestructuringInitiativeNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_7b1b6b0e-0867-4d4f-9b09-2db78e3bc514" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_7b1b6b0e-0867-4d4f-9b09-2db78e3bc514" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_ac9bc541-011d-44cf-9aaf-4e3a37a47ebe" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:to="loc_srt_ConsolidationItemsAxis_ac9bc541-011d-44cf-9aaf-4e3a37a47ebe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_c04b7418-15c2-43ff-9ed8-64839434ea14" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsAxis_ac9bc541-011d-44cf-9aaf-4e3a37a47ebe" xlink:to="loc_srt_ConsolidationItemsDomain_c04b7418-15c2-43ff-9ed8-64839434ea14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_101ab38b-6725-4bda-aec3-ce57ef592c49" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsDomain_c04b7418-15c2-43ff-9ed8-64839434ea14" xlink:to="loc_us-gaap_OperatingSegmentsMember_101ab38b-6725-4bda-aec3-ce57ef592c49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_31373eb4-0e78-4eca-9ae6-ed82a64e18a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_31373eb4-0e78-4eca-9ae6-ed82a64e18a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_cb85d99f-afc9-409a-b57d-cd5e269a76fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_31373eb4-0e78-4eca-9ae6-ed82a64e18a2" xlink:to="loc_us-gaap_SegmentDomain_cb85d99f-afc9-409a-b57d-cd5e269a76fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_GenericPharmaceuticalsSegmentMember_eb34ba34-ebbf-412f-bd79-cefde90b40da" xlink:href="endp-20210331.xsd#endp_GenericPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_cb85d99f-afc9-409a-b57d-cd5e269a76fe" xlink:to="loc_endp_GenericPharmaceuticalsSegmentMember_eb34ba34-ebbf-412f-bd79-cefde90b40da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_43322842-d712-4f11-98d8-02f8a2bcd0cc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_43322842-d712-4f11-98d8-02f8a2bcd0cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_762ef0d0-7542-4c7d-8e1f-dfd4d2657689" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_43322842-d712-4f11-98d8-02f8a2bcd0cc" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_762ef0d0-7542-4c7d-8e1f-dfd4d2657689" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_36eebd51-199a-413b-bbf1-0e589728e6b9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherRestructuringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_762ef0d0-7542-4c7d-8e1f-dfd4d2657689" xlink:to="loc_us-gaap_OtherRestructuringMember_36eebd51-199a-413b-bbf1-0e589728e6b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AcceleratedDepreciationChargesMember_e5a918f1-79d9-465b-857f-448fc4f248f2" xlink:href="endp-20210331.xsd#endp_AcceleratedDepreciationChargesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_762ef0d0-7542-4c7d-8e1f-dfd4d2657689" xlink:to="loc_endp_AcceleratedDepreciationChargesMember_e5a918f1-79d9-465b-857f-448fc4f248f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AssetImpairmentChargesMember_e29ba539-4833-4630-9767-efa9d570c698" xlink:href="endp-20210331.xsd#endp_AssetImpairmentChargesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_762ef0d0-7542-4c7d-8e1f-dfd4d2657689" xlink:to="loc_endp_AssetImpairmentChargesMember_e29ba539-4833-4630-9767-efa9d570c698" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_IncreaseInExcessInventoryReservesMember_88b7ba17-1e29-446d-94e6-2e07a2b5bca5" xlink:href="endp-20210331.xsd#endp_IncreaseInExcessInventoryReservesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_762ef0d0-7542-4c7d-8e1f-dfd4d2657689" xlink:to="loc_endp_IncreaseInExcessInventoryReservesMember_88b7ba17-1e29-446d-94e6-2e07a2b5bca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember_d151a95b-bc16-4c63-904a-c7a5475d9722" xlink:href="endp-20210331.xsd#endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_762ef0d0-7542-4c7d-8e1f-dfd4d2657689" xlink:to="loc_endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember_d151a95b-bc16-4c63-904a-c7a5475d9722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_5c399828-3bd8-44a1-8f07-a09e7f08c9c4" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:to="loc_srt_RangeAxis_5c399828-3bd8-44a1-8f07-a09e7f08c9c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c0f46cdf-4779-4a8e-aca9-27b0ea18442b" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_5c399828-3bd8-44a1-8f07-a09e7f08c9c4" xlink:to="loc_srt_RangeMember_c0f46cdf-4779-4a8e-aca9-27b0ea18442b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_6a2edee2-5984-4506-afc8-2951022c95fa" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_c0f46cdf-4779-4a8e-aca9-27b0ea18442b" xlink:to="loc_srt_MinimumMember_6a2edee2-5984-4506-afc8-2951022c95fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_a16c1358-acd4-4636-9dd6-17dbc49fdd9b" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_c0f46cdf-4779-4a8e-aca9-27b0ea18442b" xlink:to="loc_srt_MaximumMember_a16c1358-acd4-4636-9dd6-17dbc49fdd9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_9cfe84e8-1bb2-47e2-b2e4-8fbe4e734bc2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_9cfe84e8-1bb2-47e2-b2e4-8fbe4e734bc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_b053789c-dd53-450d-89ed-5324ed13646e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_9cfe84e8-1bb2-47e2-b2e4-8fbe4e734bc2" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_b053789c-dd53-450d-89ed-5324ed13646e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_6375389b-0e6b-4712-bad0-b20af5b62fc4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfSalesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_b053789c-dd53-450d-89ed-5324ed13646e" xlink:to="loc_us-gaap_CostOfSalesMember_6375389b-0e6b-4712-bad0-b20af5b62fc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_5ef61e76-1a4c-4063-b8b3-71d2f9f018a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_b053789c-dd53-450d-89ed-5324ed13646e" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_5ef61e76-1a4c-4063-b8b3-71d2f9f018a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_d5272a83-a8e6-48cf-9a26-1cf21d1c9896" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:to="loc_us-gaap_RestructuringPlanAxis_d5272a83-a8e6-48cf-9a26-1cf21d1c9896" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_c16d3416-bc8f-4550-b857-7d7245c969c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringPlanAxis_d5272a83-a8e6-48cf-9a26-1cf21d1c9896" xlink:to="loc_us-gaap_RestructuringPlanDomain_c16d3416-bc8f-4550-b857-7d7245c969c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestructuringInitiative2020Member_fe83cf05-9200-4066-9720-76e89f9f25bc" xlink:href="endp-20210331.xsd#endp_RestructuringInitiative2020Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringPlanDomain_c16d3416-bc8f-4550-b857-7d7245c969c2" xlink:to="loc_endp_RestructuringInitiative2020Member_fe83cf05-9200-4066-9720-76e89f9f25bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_a15683c0-bd2e-4f7c-9709-2b3fc147d0fd" xlink:to="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostExpectedNumberOfPositionsEliminated_feab268d-1ce0-43b0-b7c3-705429753556" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedCostExpectedNumberOfPositionsEliminated"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_us-gaap_RestructuringAndRelatedCostExpectedNumberOfPositionsEliminated_feab268d-1ce0-43b0-b7c3-705429753556" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestructuringAndRelatedCostsExpectedCostSavings_048899c2-ac48-46a0-ade0-4c55e9a539ef" xlink:href="endp-20210331.xsd#endp_RestructuringAndRelatedCostsExpectedCostSavings"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_endp_RestructuringAndRelatedCostsExpectedCostSavings_048899c2-ac48-46a0-ade0-4c55e9a539ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_04c9c263-ba21-426a-8f09-027d6f8e68c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_us-gaap_RestructuringCharges_04c9c263-ba21-426a-8f09-027d6f8e68c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_ebd8c0cc-a79e-469c-b056-25fe17d2b7c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserveAcceleratedDepreciation"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_ebd8c0cc-a79e-469c-b056-25fe17d2b7c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_1ddc0878-8787-451b-a851-2f19be62840c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_us-gaap_AssetImpairmentCharges_1ddc0878-8787-451b-a851-2f19be62840c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestructuringAndRelatedCostEmployeeCosts_8945df1a-6568-4064-b95d-fb55acb7a7e3" xlink:href="endp-20210331.xsd#endp_RestructuringAndRelatedCostEmployeeCosts"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_endp_RestructuringAndRelatedCostEmployeeCosts_8945df1a-6568-4064-b95d-fb55acb7a7e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRestructuring_744549a0-acc3-465c-bdeb-3548cedf67ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRestructuring"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_us-gaap_PaymentsForRestructuring_744549a0-acc3-465c-bdeb-3548cedf67ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_a5ec8e40-4cbb-4a05-a48c-5c86afdfa7a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedCostCostIncurredToDate1"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_a5ec8e40-4cbb-4a05-a48c-5c86afdfa7a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_d094a691-b7e8-4b0e-9e94-76d71bdfccdd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_f9558d5b-d8a9-400d-ac5a-63b199a7d220" xlink:to="loc_us-gaap_RestructuringReserveCurrent_d094a691-b7e8-4b0e-9e94-76d71bdfccdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/RestructuringPretaxNetChargesRelatedtoNovember2020RestructuringInitiativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#RestructuringPretaxNetChargesRelatedtoNovember2020RestructuringInitiativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/RestructuringPretaxNetChargesRelatedtoNovember2020RestructuringInitiativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_1b490255-6625-4ad2-9976-875c5a9b6076" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_471fee48-a831-45fa-a9d3-84e28ffd56df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_1b490255-6625-4ad2-9976-875c5a9b6076" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_471fee48-a831-45fa-a9d3-84e28ffd56df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_51570baa-61a5-45f5-8242-82f4f7964164" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_471fee48-a831-45fa-a9d3-84e28ffd56df" xlink:to="loc_us-gaap_RestructuringPlanAxis_51570baa-61a5-45f5-8242-82f4f7964164" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_9c3540ed-9775-46a0-bd32-5eadb43857c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringPlanAxis_51570baa-61a5-45f5-8242-82f4f7964164" xlink:to="loc_us-gaap_RestructuringPlanDomain_9c3540ed-9775-46a0-bd32-5eadb43857c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestructuringInitiative2020Member_bfe28e91-5f59-45a8-a0cd-84dc472de215" xlink:href="endp-20210331.xsd#endp_RestructuringInitiative2020Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringPlanDomain_9c3540ed-9775-46a0-bd32-5eadb43857c9" xlink:to="loc_endp_RestructuringInitiative2020Member_bfe28e91-5f59-45a8-a0cd-84dc472de215" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_005dccff-0a89-4bd0-bccb-c12d67a4070e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_471fee48-a831-45fa-a9d3-84e28ffd56df" xlink:to="loc_us-gaap_RestructuringCostAndReserveLineItems_005dccff-0a89-4bd0-bccb-c12d67a4070e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_4f1279d5-7c0a-4b83-a64f-8b1c3637e9c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserveAcceleratedDepreciation"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_005dccff-0a89-4bd0-bccb-c12d67a4070e" xlink:to="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_4f1279d5-7c0a-4b83-a64f-8b1c3637e9c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestructuringAndRelatedCostIncreaseInExcessInventoryReserves_0b5bc164-9437-4dbc-aa56-810264f70fa1" xlink:href="endp-20210331.xsd#endp_RestructuringAndRelatedCostIncreaseInExcessInventoryReserves"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_005dccff-0a89-4bd0-bccb-c12d67a4070e" xlink:to="loc_endp_RestructuringAndRelatedCostIncreaseInExcessInventoryReserves_0b5bc164-9437-4dbc-aa56-810264f70fa1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeveranceCosts1_c74564d6-0382-4035-a373-874b965d81a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SeveranceCosts1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_005dccff-0a89-4bd0-bccb-c12d67a4070e" xlink:to="loc_us-gaap_SeveranceCosts1_c74564d6-0382-4035-a373-874b965d81a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringCosts_13f0e4ab-b0c0-483f-9b5e-9fe0122f2126" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherRestructuringCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_005dccff-0a89-4bd0-bccb-c12d67a4070e" xlink:to="loc_us-gaap_OtherRestructuringCosts_13f0e4ab-b0c0-483f-9b5e-9fe0122f2126" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostsAndAssetImpairmentCharges_c2a24ff1-3511-4eb4-a80b-2a0de42f53af" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostsAndAssetImpairmentCharges"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_005dccff-0a89-4bd0-bccb-c12d67a4070e" xlink:to="loc_us-gaap_RestructuringCostsAndAssetImpairmentCharges_c2a24ff1-3511-4eb4-a80b-2a0de42f53af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/RestructuringPretaxNetChargesIncludedintheCondensedConsolidatedStatementofOperationsDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#RestructuringPretaxNetChargesIncludedintheCondensedConsolidatedStatementofOperationsDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/RestructuringPretaxNetChargesIncludedintheCondensedConsolidatedStatementofOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_d9cd438d-19f1-4c4d-84fb-a0c1578c7549" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_f954da7d-b2dd-4836-a8e5-0c202130c426" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_d9cd438d-19f1-4c4d-84fb-a0c1578c7549" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_f954da7d-b2dd-4836-a8e5-0c202130c426" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_8cda2ef9-e4a0-4890-858d-7fb40cdb8a17" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_f954da7d-b2dd-4836-a8e5-0c202130c426" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_8cda2ef9-e4a0-4890-858d-7fb40cdb8a17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_e7ab6b97-d464-4201-bb90-508fb7905377" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_8cda2ef9-e4a0-4890-858d-7fb40cdb8a17" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_e7ab6b97-d464-4201-bb90-508fb7905377" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_c62344f3-ab92-4de6-8109-a6f97eb856dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfSalesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_e7ab6b97-d464-4201-bb90-508fb7905377" xlink:to="loc_us-gaap_CostOfSalesMember_c62344f3-ab92-4de6-8109-a6f97eb856dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_278b5412-9a8f-47be-8a08-8d4467358364" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_e7ab6b97-d464-4201-bb90-508fb7905377" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_278b5412-9a8f-47be-8a08-8d4467358364" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_6b335b88-c18e-4e68-9c0f-fdb9f8f03e96" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_e7ab6b97-d464-4201-bb90-508fb7905377" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_6b335b88-c18e-4e68-9c0f-fdb9f8f03e96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_8cb47be4-af3f-4b82-993a-ae28d3308917" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_f954da7d-b2dd-4836-a8e5-0c202130c426" xlink:to="loc_us-gaap_RestructuringPlanAxis_8cb47be4-af3f-4b82-993a-ae28d3308917" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01f6acea-a8be-4cf8-bea6-c0cd94dd317d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringPlanAxis_8cb47be4-af3f-4b82-993a-ae28d3308917" xlink:to="loc_us-gaap_RestructuringPlanDomain_01f6acea-a8be-4cf8-bea6-c0cd94dd317d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestructuringInitiative2020Member_d6aff6ed-2394-4bf2-b02d-db91121d588a" xlink:href="endp-20210331.xsd#endp_RestructuringInitiative2020Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringPlanDomain_01f6acea-a8be-4cf8-bea6-c0cd94dd317d" xlink:to="loc_endp_RestructuringInitiative2020Member_d6aff6ed-2394-4bf2-b02d-db91121d588a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_bd01c784-8a1d-4115-be3e-cb13bc77a20d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_f954da7d-b2dd-4836-a8e5-0c202130c426" xlink:to="loc_us-gaap_RestructuringCostAndReserveLineItems_bd01c784-8a1d-4115-be3e-cb13bc77a20d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_7e62ee2f-c22a-48a9-93d6-60b45095b5dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_bd01c784-8a1d-4115-be3e-cb13bc77a20d" xlink:to="loc_us-gaap_RestructuringCharges_7e62ee2f-c22a-48a9-93d6-60b45095b5dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/RestructuringChangestotheLiabilityforNovember2020RestructuringInitiativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#RestructuringChangestotheLiabilityforNovember2020RestructuringInitiativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/RestructuringChangestotheLiabilityforNovember2020RestructuringInitiativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_23f6753c-36d9-46d9-b675-f48941b4ecf9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_bec41043-ad00-49fd-93ca-732119c36efd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_23f6753c-36d9-46d9-b675-f48941b4ecf9" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_bec41043-ad00-49fd-93ca-732119c36efd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_93e8edb5-162f-4b77-b40d-f3ca30193cea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_bec41043-ad00-49fd-93ca-732119c36efd" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_93e8edb5-162f-4b77-b40d-f3ca30193cea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_03c76d8f-0a46-4d73-9e8d-9af6011d9d7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_93e8edb5-162f-4b77-b40d-f3ca30193cea" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_03c76d8f-0a46-4d73-9e8d-9af6011d9d7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember_c152a443-94c1-483d-b132-457c55bb535e" xlink:href="endp-20210331.xsd#endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_03c76d8f-0a46-4d73-9e8d-9af6011d9d7a" xlink:to="loc_endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember_c152a443-94c1-483d-b132-457c55bb535e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_8a094efb-fcad-4257-a877-569d309b5e46" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherRestructuringMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_03c76d8f-0a46-4d73-9e8d-9af6011d9d7a" xlink:to="loc_us-gaap_OtherRestructuringMember_8a094efb-fcad-4257-a877-569d309b5e46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsAndOtherRestructuringCostsMember_34bfaed3-47e7-485d-b8b3-f1b6e6e6d2fd" xlink:href="endp-20210331.xsd#endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsAndOtherRestructuringCostsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_03c76d8f-0a46-4d73-9e8d-9af6011d9d7a" xlink:to="loc_endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsAndOtherRestructuringCostsMember_34bfaed3-47e7-485d-b8b3-f1b6e6e6d2fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_f5266186-8142-4a8c-a766-a1e0c7b38e9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_bec41043-ad00-49fd-93ca-732119c36efd" xlink:to="loc_us-gaap_RestructuringPlanAxis_f5266186-8142-4a8c-a766-a1e0c7b38e9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_4a139cbe-7394-4552-9705-d611d68f30fc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringPlanAxis_f5266186-8142-4a8c-a766-a1e0c7b38e9e" xlink:to="loc_us-gaap_RestructuringPlanDomain_4a139cbe-7394-4552-9705-d611d68f30fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestructuringInitiative2020Member_a21c4132-b6e0-4930-a4df-1d3a97bf3fc4" xlink:href="endp-20210331.xsd#endp_RestructuringInitiative2020Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringPlanDomain_4a139cbe-7394-4552-9705-d611d68f30fc" xlink:to="loc_endp_RestructuringInitiative2020Member_a21c4132-b6e0-4930-a4df-1d3a97bf3fc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_25a5dd7a-f6b6-40cc-8afc-5fc4a033bb88" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_bec41043-ad00-49fd-93ca-732119c36efd" xlink:to="loc_us-gaap_RestructuringCostAndReserveLineItems_25a5dd7a-f6b6-40cc-8afc-5fc4a033bb88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveRollForward_02b48db6-b8c4-496c-8605-b507dee3c3f0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserveRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_25a5dd7a-f6b6-40cc-8afc-5fc4a033bb88" xlink:to="loc_us-gaap_RestructuringReserveRollForward_02b48db6-b8c4-496c-8605-b507dee3c3f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_6a4e5398-febe-4dad-9f7f-b5fd5e367113" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserve"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringReserveRollForward_02b48db6-b8c4-496c-8605-b507dee3c3f0" xlink:to="loc_us-gaap_RestructuringReserve_6a4e5398-febe-4dad-9f7f-b5fd5e367113" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_e94fc3a8-8311-4a58-9efe-2e22e1763950" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringReserveRollForward_02b48db6-b8c4-496c-8605-b507dee3c3f0" xlink:to="loc_us-gaap_RestructuringCharges_e94fc3a8-8311-4a58-9efe-2e22e1763950" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRestructuring_f1ae6ae6-c364-4e7c-a1f3-2bbe5c5b6189" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRestructuring"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringReserveRollForward_02b48db6-b8c4-496c-8605-b507dee3c3f0" xlink:to="loc_us-gaap_PaymentsForRestructuring_f1ae6ae6-c364-4e7c-a1f3-2bbe5c5b6189" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_5491a1bf-4ed7-4551-a371-584dd450c47f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserve"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringReserveRollForward_02b48db6-b8c4-496c-8605-b507dee3c3f0" xlink:to="loc_us-gaap_RestructuringReserve_5491a1bf-4ed7-4551-a371-584dd450c47f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/SegmentResults" xlink:type="simple" xlink:href="endp-20210331.xsd#SegmentResults"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/SegmentResults" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_fed1da07-761d-42d2-b5b6-8ae06076bf07" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingDisclosureTextBlock_c6db5471-cc79-42af-b504-01669b6c87a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_fed1da07-761d-42d2-b5b6-8ae06076bf07" xlink:to="loc_us-gaap_SegmentReportingDisclosureTextBlock_c6db5471-cc79-42af-b504-01669b6c87a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/SegmentResultsTables" xlink:type="simple" xlink:href="endp-20210331.xsd#SegmentResultsTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/SegmentResultsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_25a1238c-e071-4bd6-a195-caad2975c2c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_3c2e5dbb-78a8-477a-890b-22d61c4d8e5d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_25a1238c-e071-4bd6-a195-caad2975c2c1" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_3c2e5dbb-78a8-477a-890b-22d61c4d8e5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_0c72365a-0ec1-4448-8239-33894ed691ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_25a1238c-e071-4bd6-a195-caad2975c2c1" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_0c72365a-0ec1-4448-8239-33894ed691ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/SegmentResultsScheduleofReportableSegmentsInformationDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#SegmentResultsScheduleofReportableSegmentsInformationDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/SegmentResultsScheduleofReportableSegmentsInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_ac60bdfe-190f-445b-90be-fa236cee0b59" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_00a9e321-64a2-4207-b7e8-30099d24af3f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_ac60bdfe-190f-445b-90be-fa236cee0b59" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_00a9e321-64a2-4207-b7e8-30099d24af3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_2439415b-7aed-4caa-9dde-cacc678bc77d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_00a9e321-64a2-4207-b7e8-30099d24af3f" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_2439415b-7aed-4caa-9dde-cacc678bc77d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_4f7b931c-681f-46bb-bb0d-515e1140211e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_2439415b-7aed-4caa-9dde-cacc678bc77d" xlink:to="loc_us-gaap_SegmentDomain_4f7b931c-681f-46bb-bb0d-515e1140211e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_BrandedPharmaceuticalsSegmentMember_829fc071-8cbf-4519-b086-bd0d0647fa15" xlink:href="endp-20210331.xsd#endp_BrandedPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_4f7b931c-681f-46bb-bb0d-515e1140211e" xlink:to="loc_endp_BrandedPharmaceuticalsSegmentMember_829fc071-8cbf-4519-b086-bd0d0647fa15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SterileInjectablesSegmentMember_46c073f6-81e7-4b17-8cfc-e0a9d3e22b8b" xlink:href="endp-20210331.xsd#endp_SterileInjectablesSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_4f7b931c-681f-46bb-bb0d-515e1140211e" xlink:to="loc_endp_SterileInjectablesSegmentMember_46c073f6-81e7-4b17-8cfc-e0a9d3e22b8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_GenericPharmaceuticalsSegmentMember_c241e3f6-0d39-47f3-b3a1-bb931d3aeed1" xlink:href="endp-20210331.xsd#endp_GenericPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_4f7b931c-681f-46bb-bb0d-515e1140211e" xlink:to="loc_endp_GenericPharmaceuticalsSegmentMember_c241e3f6-0d39-47f3-b3a1-bb931d3aeed1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_InternationalPharmaceuticalsSegmentMember_cad5be3a-c543-4a52-a858-819d9f45ee18" xlink:href="endp-20210331.xsd#endp_InternationalPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_4f7b931c-681f-46bb-bb0d-515e1140211e" xlink:to="loc_endp_InternationalPharmaceuticalsSegmentMember_cad5be3a-c543-4a52-a858-819d9f45ee18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_f29c008d-a5e9-40be-a192-a17ecaec9664" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_00a9e321-64a2-4207-b7e8-30099d24af3f" xlink:to="loc_us-gaap_SegmentReportingInformationLineItems_f29c008d-a5e9-40be-a192-a17ecaec9664" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_465f04c6-ba76-4467-8364-eaee3582ade5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f29c008d-a5e9-40be-a192-a17ecaec9664" xlink:to="loc_us-gaap_NumberOfReportableSegments_465f04c6-ba76-4467-8364-eaee3582ade5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_123a6f3e-ee98-4981-9ca6-b0230a1ae56b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f29c008d-a5e9-40be-a192-a17ecaec9664" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_123a6f3e-ee98-4981-9ca6-b0230a1ae56b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AdjustedIncomeLossBeforeIncomeTax_1c987d1c-8d5a-45d0-b902-43e0bc4269bc" xlink:href="endp-20210331.xsd#endp_AdjustedIncomeLossBeforeIncomeTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f29c008d-a5e9-40be-a192-a17ecaec9664" xlink:to="loc_endp_AdjustedIncomeLossBeforeIncomeTax_1c987d1c-8d5a-45d0-b902-43e0bc4269bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/SegmentResultsScheduleofReconciliationsofConsolidatedAdjustedIncomeLossBeforeIncomeTaxDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#SegmentResultsScheduleofReconciliationsofConsolidatedAdjustedIncomeLossBeforeIncomeTaxDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/SegmentResultsScheduleofReconciliationsofConsolidatedAdjustedIncomeLossBeforeIncomeTaxDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_06931f3c-ab5d-42f7-960e-3a43d59f0985" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1db1fccb-cb44-4834-b348-205b949512d2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_06931f3c-ab5d-42f7-960e-3a43d59f0985" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1db1fccb-cb44-4834-b348-205b949512d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_3d377d29-eadb-4698-8f98-77cc4efd4c1b" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1db1fccb-cb44-4834-b348-205b949512d2" xlink:to="loc_srt_ConsolidationItemsAxis_3d377d29-eadb-4698-8f98-77cc4efd4c1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_5cd4e8fa-d516-473d-8d2d-2752ac8bbc10" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsAxis_3d377d29-eadb-4698-8f98-77cc4efd4c1b" xlink:to="loc_srt_ConsolidationItemsDomain_5cd4e8fa-d516-473d-8d2d-2752ac8bbc10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_e36da8d5-f4b1-4c69-b626-16a1944ba96e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MaterialReconcilingItemsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsDomain_5cd4e8fa-d516-473d-8d2d-2752ac8bbc10" xlink:to="loc_us-gaap_MaterialReconcilingItemsMember_e36da8d5-f4b1-4c69-b626-16a1944ba96e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_b7783d51-5c62-4e32-ba6a-f4d5e822f074" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ConsolidationItemsDomain_5cd4e8fa-d516-473d-8d2d-2752ac8bbc10" xlink:to="loc_us-gaap_OperatingSegmentsMember_b7783d51-5c62-4e32-ba6a-f4d5e822f074" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_41b8261f-3c46-4801-831c-300fec429b41" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1db1fccb-cb44-4834-b348-205b949512d2" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_41b8261f-3c46-4801-831c-300fec429b41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_e3e378ad-331e-4172-8487-62fe22266d24" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_41b8261f-3c46-4801-831c-300fec429b41" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_e3e378ad-331e-4172-8487-62fe22266d24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_305dc8f6-ce8b-4c9c-b49a-0fd09170bd5c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_e3e378ad-331e-4172-8487-62fe22266d24" xlink:to="loc_us-gaap_EmployeeSeveranceMember_305dc8f6-ce8b-4c9c-b49a-0fd09170bd5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_4f3b7681-19b6-462b-b0b5-4bff29c775e0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherRestructuringMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_e3e378ad-331e-4172-8487-62fe22266d24" xlink:to="loc_us-gaap_OtherRestructuringMember_4f3b7681-19b6-462b-b0b5-4bff29c775e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_9560eb8c-5719-43cf-9bec-1347c9f7610b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1db1fccb-cb44-4834-b348-205b949512d2" xlink:to="loc_us-gaap_DebtInstrumentAxis_9560eb8c-5719-43cf-9bec-1347c9f7610b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_26fabdcf-33d1-47fd-b1eb-d1d705966d82" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_9560eb8c-5719-43cf-9bec-1347c9f7610b" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_26fabdcf-33d1-47fd-b1eb-d1d705966d82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member_872df444-b8df-4761-85d3-18c0433fe5e5" xlink:href="endp-20210331.xsd#endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_26fabdcf-33d1-47fd-b1eb-d1d705966d82" xlink:to="loc_endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member_872df444-b8df-4761-85d3-18c0433fe5e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_158b1866-d352-4a58-9529-a21b288ef7cc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1db1fccb-cb44-4834-b348-205b949512d2" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_158b1866-d352-4a58-9529-a21b288ef7cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_4b2b31f1-2623-4745-b544-22be0e9ef620" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_158b1866-d352-4a58-9529-a21b288ef7cc" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_4b2b31f1-2623-4745-b544-22be0e9ef620" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_d9291d70-99a6-446d-b656-fada481df6c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_4b2b31f1-2623-4745-b544-22be0e9ef620" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_d9291d70-99a6-446d-b656-fada481df6c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_1db1fccb-cb44-4834-b348-205b949512d2" xlink:to="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_3e1503d5-baed-4c98-8442-e95641dd7f2d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_3e1503d5-baed-4c98-8442-e95641dd7f2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_1d8cb4fe-8bef-42bb-9f7c-4815386a4dfe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_1d8cb4fe-8bef-42bb-9f7c-4815386a4dfe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SegmentReportingInformationUnallocatedCorporateExpense_bea1cb15-2f24-4406-b215-ce00e7b9952a" xlink:href="endp-20210331.xsd#endp_SegmentReportingInformationUnallocatedCorporateExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_endp_SegmentReportingInformationUnallocatedCorporateExpense_bea1cb15-2f24-4406-b215-ce00e7b9952a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_e2ff93c0-6866-4207-ab89-f8c6645c0311" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_e2ff93c0-6866-4207-ab89-f8c6645c0311" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_UpfrontAndMilestonePaymentsToPartners_bb37fc97-e69a-426b-8910-1cb35d7ed6c6" xlink:href="endp-20210331.xsd#endp_UpfrontAndMilestonePaymentsToPartners"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_endp_UpfrontAndMilestonePaymentsToPartners_bb37fc97-e69a-426b-8910-1cb35d7ed6c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_CostReductionInitiatives_e2667ae3-a9e2-4dff-9217-f71ead2c85d1" xlink:href="endp-20210331.xsd#endp_CostReductionInitiatives"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_endp_CostReductionInitiatives_e2667ae3-a9e2-4dff-9217-f71ead2c85d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyLossInPeriod_3d79f68a-3d3b-457c-8115-88ebf978a062" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyLossInPeriod"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_LossContingencyLossInPeriod_3d79f68a-3d3b-457c-8115-88ebf978a062" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalFees_7e64b1eb-4594-4cfe-a748-5cdbbb628d9d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LegalFees"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_LegalFees_7e64b1eb-4594-4cfe-a748-5cdbbb628d9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_e5187390-87a0-477d-8785-de4531c0281c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_AssetImpairmentCharges_e5187390-87a0-477d-8785-de4531c0281c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_418a9fe1-a94b-41bf-839b-51efa49cc9b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_418a9fe1-a94b-41bf-839b-51efa49cc9b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_87da7337-cef0-44a3-aa24-82810497ce09" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_87da7337-cef0-44a3-aa24-82810497ce09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentForLongTermIntercompanyTransactionsGrossOfTax_96400644-63ef-43d1-b269-6b2cd0ba3fc1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentForLongTermIntercompanyTransactionsGrossOfTax"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_AdjustmentForLongTermIntercompanyTransactionsGrossOfTax_96400644-63ef-43d1-b269-6b2cd0ba3fc1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonrecurringIncomeExpense_b1df5e4d-427d-4425-a2fc-afa93182e644" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonrecurringIncomeExpense"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_OtherNonrecurringIncomeExpense_b1df5e4d-427d-4425-a2fc-afa93182e644" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AdjustedIncomeLossBeforeIncomeTax_0f9776dc-ba70-4d2a-a5d4-bf47519d6543" xlink:href="endp-20210331.xsd#endp_AdjustedIncomeLossBeforeIncomeTax"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_endp_AdjustedIncomeLossBeforeIncomeTax_0f9776dc-ba70-4d2a-a5d4-bf47519d6543" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_34b11b87-d192-4b64-921a-dd32fc4f2037" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_RestructuringCharges_34b11b87-d192-4b64-921a-dd32fc4f2037" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_cfdc802e-62a5-489d-b74d-349e182b7def" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserveAcceleratedDepreciation"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_1fd1026e-3cd6-4a82-9706-647d6f44201b" xlink:to="loc_us-gaap_RestructuringReserveAcceleratedDepreciation_cfdc802e-62a5-489d-b74d-349e182b7def" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/SegmentResultsScheduleofDisaggregationofRevenuesDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#SegmentResultsScheduleofDisaggregationofRevenuesDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/SegmentResultsScheduleofDisaggregationofRevenuesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_6df0c5c5-7c8e-453e-833d-125a3542505b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_b9e179ab-9c88-435c-95fe-d41e95d36f48" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_6df0c5c5-7c8e-453e-833d-125a3542505b" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_b9e179ab-9c88-435c-95fe-d41e95d36f48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_1812389b-22ba-4f71-9972-86c7f9aebddc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b9e179ab-9c88-435c-95fe-d41e95d36f48" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_1812389b-22ba-4f71-9972-86c7f9aebddc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_88ce160d-9726-4ea6-baca-9205307c7a6f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_1812389b-22ba-4f71-9972-86c7f9aebddc" xlink:to="loc_us-gaap_SegmentDomain_88ce160d-9726-4ea6-baca-9205307c7a6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_BrandedPharmaceuticalsSegmentMember_14d374e0-840e-4643-b5cc-97fd27b0dde7" xlink:href="endp-20210331.xsd#endp_BrandedPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_88ce160d-9726-4ea6-baca-9205307c7a6f" xlink:to="loc_endp_BrandedPharmaceuticalsSegmentMember_14d374e0-840e-4643-b5cc-97fd27b0dde7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SterileInjectablesSegmentMember_6c4d1d5e-7122-490b-945b-e8cdc42830ea" xlink:href="endp-20210331.xsd#endp_SterileInjectablesSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_88ce160d-9726-4ea6-baca-9205307c7a6f" xlink:to="loc_endp_SterileInjectablesSegmentMember_6c4d1d5e-7122-490b-945b-e8cdc42830ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_GenericPharmaceuticalsSegmentMember_b01a6158-a0f4-4991-a733-c74f25eab3ac" xlink:href="endp-20210331.xsd#endp_GenericPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_88ce160d-9726-4ea6-baca-9205307c7a6f" xlink:to="loc_endp_GenericPharmaceuticalsSegmentMember_b01a6158-a0f4-4991-a733-c74f25eab3ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_InternationalPharmaceuticalsSegmentMember_f823111a-91e1-4cfc-9bef-b9e44e5e9b3a" xlink:href="endp-20210331.xsd#endp_InternationalPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_88ce160d-9726-4ea6-baca-9205307c7a6f" xlink:to="loc_endp_InternationalPharmaceuticalsSegmentMember_f823111a-91e1-4cfc-9bef-b9e44e5e9b3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_3d0f5dc4-1261-40f3-b34d-e37090bd21a0" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b9e179ab-9c88-435c-95fe-d41e95d36f48" xlink:to="loc_srt_ProductOrServiceAxis_3d0f5dc4-1261-40f3-b34d-e37090bd21a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6470e783-1a68-4cde-ba3f-cb05b46de07a" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_3d0f5dc4-1261-40f3-b34d-e37090bd21a0" xlink:to="loc_srt_ProductsAndServicesDomain_6470e783-1a68-4cde-ba3f-cb05b46de07a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SpecialtyProductsMember_a5afe87a-e861-406c-b7cc-dfb4ae3ead2e" xlink:href="endp-20210331.xsd#endp_SpecialtyProductsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6470e783-1a68-4cde-ba3f-cb05b46de07a" xlink:to="loc_endp_SpecialtyProductsMember_a5afe87a-e861-406c-b7cc-dfb4ae3ead2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_XiaflexMember_8b388202-2ebb-4aa6-947e-2c9ca63cc5c1" xlink:href="endp-20210331.xsd#endp_XiaflexMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SpecialtyProductsMember_a5afe87a-e861-406c-b7cc-dfb4ae3ead2e" xlink:to="loc_endp_XiaflexMember_8b388202-2ebb-4aa6-947e-2c9ca63cc5c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SUPPRELINLAMember_71509822-6dfa-47ff-8b60-5466a46ab480" xlink:href="endp-20210331.xsd#endp_SUPPRELINLAMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SpecialtyProductsMember_a5afe87a-e861-406c-b7cc-dfb4ae3ead2e" xlink:to="loc_endp_SUPPRELINLAMember_71509822-6dfa-47ff-8b60-5466a46ab480" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_OtherSpecialtyProductsMember_5f212836-0125-4e82-b55e-45409a3e90e2" xlink:href="endp-20210331.xsd#endp_OtherSpecialtyProductsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SpecialtyProductsMember_a5afe87a-e861-406c-b7cc-dfb4ae3ead2e" xlink:to="loc_endp_OtherSpecialtyProductsMember_5f212836-0125-4e82-b55e-45409a3e90e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EstablishedProductsMember_892f28e9-2326-479e-846e-dac5b90606b9" xlink:href="endp-20210331.xsd#endp_EstablishedProductsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6470e783-1a68-4cde-ba3f-cb05b46de07a" xlink:to="loc_endp_EstablishedProductsMember_892f28e9-2326-479e-846e-dac5b90606b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_PERCOCETMember_c62f8c3a-d7a6-4c45-a194-e12ea016d525" xlink:href="endp-20210331.xsd#endp_PERCOCETMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_EstablishedProductsMember_892f28e9-2326-479e-846e-dac5b90606b9" xlink:to="loc_endp_PERCOCETMember_c62f8c3a-d7a6-4c45-a194-e12ea016d525" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LidodermMember_9530a57a-8ffe-4b73-bb8c-d86faedf7ae1" xlink:href="endp-20210331.xsd#endp_LidodermMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_EstablishedProductsMember_892f28e9-2326-479e-846e-dac5b90606b9" xlink:to="loc_endp_LidodermMember_9530a57a-8ffe-4b73-bb8c-d86faedf7ae1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_OtherEstablishedProductsMember_d4d0fdbb-618e-4188-86d0-c7287b58da0f" xlink:href="endp-20210331.xsd#endp_OtherEstablishedProductsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_EstablishedProductsMember_892f28e9-2326-479e-846e-dac5b90606b9" xlink:to="loc_endp_OtherEstablishedProductsMember_d4d0fdbb-618e-4188-86d0-c7287b58da0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_VasostrictMember_917ed4ef-cc19-44c3-930c-a956c7d14790" xlink:href="endp-20210331.xsd#endp_VasostrictMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6470e783-1a68-4cde-ba3f-cb05b46de07a" xlink:to="loc_endp_VasostrictMember_917ed4ef-cc19-44c3-930c-a956c7d14790" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AdrenalinMember_75ce4094-d64d-41ed-936a-f4a1cbcb5647" xlink:href="endp-20210331.xsd#endp_AdrenalinMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6470e783-1a68-4cde-ba3f-cb05b46de07a" xlink:to="loc_endp_AdrenalinMember_75ce4094-d64d-41ed-936a-f4a1cbcb5647" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_OtherSterileInjectablesMember_f59ca14e-b701-4247-b703-46081b6b0ea9" xlink:href="endp-20210331.xsd#endp_OtherSterileInjectablesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6470e783-1a68-4cde-ba3f-cb05b46de07a" xlink:to="loc_endp_OtherSterileInjectablesMember_f59ca14e-b701-4247-b703-46081b6b0ea9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_72fbe408-5f4e-407c-a126-bd37a0b85be6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b9e179ab-9c88-435c-95fe-d41e95d36f48" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_72fbe408-5f4e-407c-a126-bd37a0b85be6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a0d21e97-869f-46b2-b7b6-f087e99e77d6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_72fbe408-5f4e-407c-a126-bd37a0b85be6" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a0d21e97-869f-46b2-b7b6-f087e99e77d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerMember_3bb6100a-af10-44d0-90d1-d1306bf80ea9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a0d21e97-869f-46b2-b7b6-f087e99e77d6" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerMember_3bb6100a-af10-44d0-90d1-d1306bf80ea9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_475a7476-9973-4b81-831a-12df1d6313b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b9e179ab-9c88-435c-95fe-d41e95d36f48" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_475a7476-9973-4b81-831a-12df1d6313b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_a6773a3d-351d-4292-a824-2eced190c615" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_475a7476-9973-4b81-831a-12df1d6313b1" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_a6773a3d-351d-4292-a824-2eced190c615" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductConcentrationRiskMember_c3e71f8a-f3ec-4e0c-8e8d-f8b3def6912c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProductConcentrationRiskMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_a6773a3d-351d-4292-a824-2eced190c615" xlink:to="loc_us-gaap_ProductConcentrationRiskMember_c3e71f8a-f3ec-4e0c-8e8d-f8b3def6912c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_1085bedd-f85f-4cdd-b8f9-0c9e7c0934aa" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b9e179ab-9c88-435c-95fe-d41e95d36f48" xlink:to="loc_srt_RangeAxis_1085bedd-f85f-4cdd-b8f9-0c9e7c0934aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_5bc0352e-b442-4453-bb27-bae7126956e6" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_1085bedd-f85f-4cdd-b8f9-0c9e7c0934aa" xlink:to="loc_srt_RangeMember_5bc0352e-b442-4453-bb27-bae7126956e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_92919c18-f4a0-42e6-b04b-bb83fb4161ba" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_5bc0352e-b442-4453-bb27-bae7126956e6" xlink:to="loc_srt_MaximumMember_92919c18-f4a0-42e6-b04b-bb83fb4161ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_8bf6702a-b182-45c6-87ea-67dddc2c244d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b9e179ab-9c88-435c-95fe-d41e95d36f48" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_8bf6702a-b182-45c6-87ea-67dddc2c244d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_328fb13b-5112-4164-bb40-9486278feebf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_8bf6702a-b182-45c6-87ea-67dddc2c244d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_328fb13b-5112-4164-bb40-9486278feebf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ProductLineRevenueReportingThreshold_6179ef38-ee77-4aa8-83c5-0b73bbf3a4cd" xlink:href="endp-20210331.xsd#endp_ProductLineRevenueReportingThreshold"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_8bf6702a-b182-45c6-87ea-67dddc2c244d" xlink:to="loc_endp_ProductLineRevenueReportingThreshold_6179ef38-ee77-4aa8-83c5-0b73bbf3a4cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_0a9bd685-fab8-4fee-9394-b152f3203b9a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_8bf6702a-b182-45c6-87ea-67dddc2c244d" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_0a9bd685-fab8-4fee-9394-b152f3203b9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="endp-20210331.xsd#FairValueMeasurements"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_09d9cbc6-cf93-4b64-8c89-8ba55227c507" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_ab11eab0-0a5b-47ca-b90f-285a0ae25aac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_09d9cbc6-cf93-4b64-8c89-8ba55227c507" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_ab11eab0-0a5b-47ca-b90f-285a0ae25aac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="endp-20210331.xsd#FairValueMeasurementsTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_f5bbf122-f6a6-4429-99f0-f8026c244fc1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_15401dc4-d62e-4f13-b84e-0e079c33a3b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_f5bbf122-f6a6-4429-99f0-f8026c244fc1" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_15401dc4-d62e-4f13-b84e-0e079c33a3b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_dba3ee62-1e11-4e1a-b83d-6961376b357b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_f5bbf122-f6a6-4429-99f0-f8026c244fc1" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_dba3ee62-1e11-4e1a-b83d-6961376b357b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnNonrecurringBasisTextBlock_8c0fd8b5-8afb-40cc-8461-8296203c7385" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnNonrecurringBasisTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_f5bbf122-f6a6-4429-99f0-f8026c244fc1" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnNonrecurringBasisTextBlock_8c0fd8b5-8afb-40cc-8461-8296203c7385" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/FairValueMeasurementsRestrictedCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#FairValueMeasurementsRestrictedCashandCashEquivalentsDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/FairValueMeasurementsRestrictedCashandCashEquivalentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_023f62ae-6fd1-4d81-8c5b-4743a553fbd9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_c4c29512-8163-4ca1-a442-5402659376ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_023f62ae-6fd1-4d81-8c5b-4743a553fbd9" xlink:to="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_c4c29512-8163-4ca1-a442-5402659376ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_80414f76-8ba8-49a0-8300-589aa65691ab" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_c4c29512-8163-4ca1-a442-5402659376ef" xlink:to="loc_srt_LitigationCaseAxis_80414f76-8ba8-49a0-8300-589aa65691ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_c72fc641-b559-46b1-90cc-215ee52f5163" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseAxis_80414f76-8ba8-49a0-8300-589aa65691ab" xlink:to="loc_srt_LitigationCaseTypeDomain_c72fc641-b559-46b1-90cc-215ee52f5163" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_VaginalMeshCasesMember_d3e99342-90de-4336-87f4-dcb875aa972f" xlink:href="endp-20210331.xsd#endp_VaginalMeshCasesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_c72fc641-b559-46b1-90cc-215ee52f5163" xlink:to="loc_endp_VaginalMeshCasesMember_d3e99342-90de-4336-87f4-dcb875aa972f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_b4c1d3d2-19b8-452e-85dd-cfdf1acfaf69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_c4c29512-8163-4ca1-a442-5402659376ef" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_b4c1d3d2-19b8-452e-85dd-cfdf1acfaf69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_65a27c93-11e6-43f4-950a-e6c453f033f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_b4c1d3d2-19b8-452e-85dd-cfdf1acfaf69" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_65a27c93-11e6-43f4-950a-e6c453f033f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestrictedCashAndCashEquivalentsInsuranceCoverageMember_5e636735-65fb-43e9-a117-f352a89f0c9f" xlink:href="endp-20210331.xsd#endp_RestrictedCashAndCashEquivalentsInsuranceCoverageMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_65a27c93-11e6-43f4-950a-e6c453f033f7" xlink:to="loc_endp_RestrictedCashAndCashEquivalentsInsuranceCoverageMember_5e636735-65fb-43e9-a117-f352a89f0c9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_5eafca1a-a3eb-4390-8ee4-2fa25a86554f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_c4c29512-8163-4ca1-a442-5402659376ef" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_5eafca1a-a3eb-4390-8ee4-2fa25a86554f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFunds_dab57a51-ee2f-44d1-a01a-fb50b0f91974" xlink:href="endp-20210331.xsd#endp_SettlementFunds"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_5eafca1a-a3eb-4390-8ee4-2fa25a86554f" xlink:to="loc_endp_SettlementFunds_dab57a51-ee2f-44d1-a01a-fb50b0f91974" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_cbeaabdd-c4a5-4019-bd79-10897a98c79e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_5eafca1a-a3eb-4390-8ee4-2fa25a86554f" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_cbeaabdd-c4a5-4019-bd79-10897a98c79e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/FairValueMeasurementsFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#FairValueMeasurementsFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/FairValueMeasurementsFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_ac3035e1-f32b-4925-a892-5a9e05d5907b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8ebfe215-738b-441b-8d53-712d12da1804" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_ac3035e1-f32b-4925-a892-5a9e05d5907b" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8ebfe215-738b-441b-8d53-712d12da1804" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_e0bbada3-05b2-4f8c-961c-26211f108788" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8ebfe215-738b-441b-8d53-712d12da1804" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_e0bbada3-05b2-4f8c-961c-26211f108788" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_8153e1a5-6f2e-4218-b94e-e6e7b818ee37" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_e0bbada3-05b2-4f8c-961c-26211f108788" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_8153e1a5-6f2e-4218-b94e-e6e7b818ee37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_77d31ca9-b7ce-4eff-8bfa-95e9cfb4d200" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_8153e1a5-6f2e-4218-b94e-e6e7b818ee37" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_77d31ca9-b7ce-4eff-8bfa-95e9cfb4d200" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ead45af7-96db-4057-ab77-2a15a9a1c99c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8ebfe215-738b-441b-8d53-712d12da1804" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ead45af7-96db-4057-ab77-2a15a9a1c99c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a5c1a8c5-34ce-49c5-9663-f6b53d5b0afd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ead45af7-96db-4057-ab77-2a15a9a1c99c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a5c1a8c5-34ce-49c5-9663-f6b53d5b0afd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_e23e9f0e-3a04-4c58-9987-be35549fe16c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a5c1a8c5-34ce-49c5-9663-f6b53d5b0afd" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_e23e9f0e-3a04-4c58-9987-be35549fe16c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_dafd3839-3e87-4f08-b1af-641f79efaae7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a5c1a8c5-34ce-49c5-9663-f6b53d5b0afd" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_dafd3839-3e87-4f08-b1af-641f79efaae7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_2bb0a082-f894-4b2e-a775-e3a5733ac701" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a5c1a8c5-34ce-49c5-9663-f6b53d5b0afd" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_2bb0a082-f894-4b2e-a775-e3a5733ac701" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_d3d7ce2c-24b9-42d2-acec-ef8a6846f355" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8ebfe215-738b-441b-8d53-712d12da1804" xlink:to="loc_us-gaap_FinancialInstrumentAxis_d3d7ce2c-24b9-42d2-acec-ef8a6846f355" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9fa10af4-8b6c-4351-b978-56c517c05861" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_d3d7ce2c-24b9-42d2-acec-ef8a6846f355" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9fa10af4-8b6c-4351-b978-56c517c05861" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_38f1a9e9-a2b4-4598-9984-48b49f183eab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9fa10af4-8b6c-4351-b978-56c517c05861" xlink:to="loc_us-gaap_MoneyMarketFundsMember_38f1a9e9-a2b4-4598-9984-48b49f183eab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_35c02547-19ff-45e8-9202-5cc28af50825" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8ebfe215-738b-441b-8d53-712d12da1804" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_35c02547-19ff-45e8-9202-5cc28af50825" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_cfe5a3f6-23f3-4d3c-baa2-dfe1603190fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_35c02547-19ff-45e8-9202-5cc28af50825" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_cfe5a3f6-23f3-4d3c-baa2-dfe1603190fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AcquisitionRelatedContingentConsiderationShortTermMember_56613f03-6c29-4fa8-ba6e-66ec12be369c" xlink:href="endp-20210331.xsd#endp_AcquisitionRelatedContingentConsiderationShortTermMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_cfe5a3f6-23f3-4d3c-baa2-dfe1603190fd" xlink:to="loc_endp_AcquisitionRelatedContingentConsiderationShortTermMember_56613f03-6c29-4fa8-ba6e-66ec12be369c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AcquisitionRelatedContingentConsiderationLongTermMember_b3ba0544-466c-42eb-b53f-927a7f5af8df" xlink:href="endp-20210331.xsd#endp_AcquisitionRelatedContingentConsiderationLongTermMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_cfe5a3f6-23f3-4d3c-baa2-dfe1603190fd" xlink:to="loc_endp_AcquisitionRelatedContingentConsiderationLongTermMember_b3ba0544-466c-42eb-b53f-927a7f5af8df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_2a53754a-f0cb-4f74-9db7-45b5e8674e4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_8ebfe215-738b-441b-8d53-712d12da1804" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_2a53754a-f0cb-4f74-9db7-45b5e8674e4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_ed054b6d-c438-42b1-85ae-aeeac6126f77" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_2a53754a-f0cb-4f74-9db7-45b5e8674e4d" xlink:to="loc_us-gaap_AssetsAbstract_ed054b6d-c438-42b1-85ae-aeeac6126f77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_1cc1ac4f-fb5c-462c-ba87-dd2a18ba4b5f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_ed054b6d-c438-42b1-85ae-aeeac6126f77" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_1cc1ac4f-fb5c-462c-ba87-dd2a18ba4b5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract_9d5be6d0-3d70-4878-9b8e-5da303b83258" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_2a53754a-f0cb-4f74-9db7-45b5e8674e4d" xlink:to="loc_us-gaap_LiabilitiesAbstract_9d5be6d0-3d70-4878-9b8e-5da303b83258" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_51ae8a28-31a0-4888-be29-2a10c4186cc9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_9d5be6d0-3d70-4878-9b8e-5da303b83258" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_51ae8a28-31a0-4888-be29-2a10c4186cc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#FairValueMeasurementsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_56f5ccc7-2320-4186-b562-4a7763972a09" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1f970309-eebe-4951-b51d-830a5a6ae646" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_56f5ccc7-2320-4186-b562-4a7763972a09" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1f970309-eebe-4951-b51d-830a5a6ae646" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_90095575-d720-43bb-84ee-1e1d074d9a92" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1f970309-eebe-4951-b51d-830a5a6ae646" xlink:to="loc_us-gaap_FinancialInstrumentAxis_90095575-d720-43bb-84ee-1e1d074d9a92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_bf63ee52-00ed-4d2d-87cc-23948c61dfbe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_90095575-d720-43bb-84ee-1e1d074d9a92" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_bf63ee52-00ed-4d2d-87cc-23948c61dfbe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_5857128a-41d4-460f-a87e-8f7d70bb166d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_bf63ee52-00ed-4d2d-87cc-23948c61dfbe" xlink:to="loc_us-gaap_MoneyMarketFundsMember_5857128a-41d4-460f-a87e-8f7d70bb166d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_bebeea2b-bee3-4a82-868a-12c69b5ec0ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1f970309-eebe-4951-b51d-830a5a6ae646" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_bebeea2b-bee3-4a82-868a-12c69b5ec0ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_f2585fff-52fe-4ca3-8670-f77df9fb2ca5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_bebeea2b-bee3-4a82-868a-12c69b5ec0ac" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_f2585fff-52fe-4ca3-8670-f77df9fb2ca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputDiscountRateMember_710d928c-1719-4120-8867-d954eec3b8e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputDiscountRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_f2585fff-52fe-4ca3-8670-f77df9fb2ca5" xlink:to="loc_us-gaap_MeasurementInputDiscountRateMember_710d928c-1719-4120-8867-d954eec3b8e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_a9548e81-b1af-4953-9734-442963751777" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1f970309-eebe-4951-b51d-830a5a6ae646" xlink:to="loc_us-gaap_InvestmentTypeAxis_a9548e81-b1af-4953-9734-442963751777" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_3d26ac14-4b38-4ff0-86e7-dc6dc5ede18f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_a9548e81-b1af-4953-9734-442963751777" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_3d26ac14-4b38-4ff0-86e7-dc6dc5ede18f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_RestrictedCashAndCashEquivalentsMember_931693aa-7d2e-4f9e-9351-831c1eed90df" xlink:href="endp-20210331.xsd#endp_RestrictedCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_3d26ac14-4b38-4ff0-86e7-dc6dc5ede18f" xlink:to="loc_endp_RestrictedCashAndCashEquivalentsMember_931693aa-7d2e-4f9e-9351-831c1eed90df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b016debd-968f-4803-8cdd-61d628661a8d" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1f970309-eebe-4951-b51d-830a5a6ae646" xlink:to="loc_srt_RangeAxis_b016debd-968f-4803-8cdd-61d628661a8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_5a8fec32-e1ae-4a69-a091-3606351965c9" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_b016debd-968f-4803-8cdd-61d628661a8d" xlink:to="loc_srt_RangeMember_5a8fec32-e1ae-4a69-a091-3606351965c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_92d29fd4-096f-4b42-a6ed-b954ec0155ca" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_5a8fec32-e1ae-4a69-a091-3606351965c9" xlink:to="loc_srt_MinimumMember_92d29fd4-096f-4b42-a6ed-b954ec0155ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_fcf51958-f635-49e7-bd8f-a9e46a70ffc7" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_5a8fec32-e1ae-4a69-a091-3606351965c9" xlink:to="loc_srt_MaximumMember_fcf51958-f635-49e7-bd8f-a9e46a70ffc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_WeightedAverageMember_52213767-4d9c-4012-822f-d0b7be699b92" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_WeightedAverageMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_5a8fec32-e1ae-4a69-a091-3606351965c9" xlink:to="loc_srt_WeightedAverageMember_52213767-4d9c-4012-822f-d0b7be699b92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1b289ec9-fb43-48de-91be-8d0f32682d86" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_1f970309-eebe-4951-b51d-830a5a6ae646" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1b289ec9-fb43-48de-91be-8d0f32682d86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFunds_ba6cb64f-c6b3-4dc6-9c54-4a572e76bcde" xlink:href="endp-20210331.xsd#endp_SettlementFunds"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1b289ec9-fb43-48de-91be-8d0f32682d86" xlink:to="loc_endp_SettlementFunds_ba6cb64f-c6b3-4dc6-9c54-4a572e76bcde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_f164ba1f-1272-41de-bde9-e2153abbb319" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_1b289ec9-fb43-48de-91be-8d0f32682d86" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_f164ba1f-1272-41de-bde9-e2153abbb319" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/FairValueMeasurementsFinancialLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingSignificantUnobservableInputsDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#FairValueMeasurementsFinancialLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingSignificantUnobservableInputsDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/FairValueMeasurementsFinancialLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingSignificantUnobservableInputsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_90ea694e-517f-4a31-a68d-75f3699f1813" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_f6733d5a-6c21-4618-a45d-aa7a4d87752a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_90ea694e-517f-4a31-a68d-75f3699f1813" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_f6733d5a-6c21-4618-a45d-aa7a4d87752a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_f4525386-d0e1-4eb8-b843-ea5f77e7a1c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_f6733d5a-6c21-4618-a45d-aa7a4d87752a" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_f4525386-d0e1-4eb8-b843-ea5f77e7a1c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_232e3740-e3ef-4ec2-90c8-c21df3b39656" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_f4525386-d0e1-4eb8-b843-ea5f77e7a1c1" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_232e3740-e3ef-4ec2-90c8-c21df3b39656" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AcquisitionRelatedContingentConsiderationMember_3614fa6a-a935-4f74-acb6-60b82b9fcbf2" xlink:href="endp-20210331.xsd#endp_AcquisitionRelatedContingentConsiderationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_232e3740-e3ef-4ec2-90c8-c21df3b39656" xlink:to="loc_endp_AcquisitionRelatedContingentConsiderationMember_3614fa6a-a935-4f74-acb6-60b82b9fcbf2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_03bd36cb-15eb-4017-9266-0d108f3d0ff1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_f6733d5a-6c21-4618-a45d-aa7a4d87752a" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_03bd36cb-15eb-4017-9266-0d108f3d0ff1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_71e12d26-1c11-4e1f-a96b-2e10d4984feb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_03bd36cb-15eb-4017-9266-0d108f3d0ff1" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_71e12d26-1c11-4e1f-a96b-2e10d4984feb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AuxiliumPharmaceuticalsInc.Member_fa4d8b7a-c0ab-44b1-a25b-489ab4b42364" xlink:href="endp-20210331.xsd#endp_AuxiliumPharmaceuticalsInc.Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_71e12d26-1c11-4e1f-a96b-2e10d4984feb" xlink:to="loc_endp_AuxiliumPharmaceuticalsInc.Member_fa4d8b7a-c0ab-44b1-a25b-489ab4b42364" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LehighValleyTechnologiesInc.Member_9b6faeee-f9aa-4ba1-b4d2-9e30e0de4543" xlink:href="endp-20210331.xsd#endp_LehighValleyTechnologiesInc.Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_71e12d26-1c11-4e1f-a96b-2e10d4984feb" xlink:to="loc_endp_LehighValleyTechnologiesInc.Member_9b6faeee-f9aa-4ba1-b4d2-9e30e0de4543" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_OtherAcquisitionsExcludingVoltarenMember_5644c6e1-d08e-46c4-aae2-0eedf338adbb" xlink:href="endp-20210331.xsd#endp_OtherAcquisitionsExcludingVoltarenMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_71e12d26-1c11-4e1f-a96b-2e10d4984feb" xlink:to="loc_endp_OtherAcquisitionsExcludingVoltarenMember_5644c6e1-d08e-46c4-aae2-0eedf338adbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_c0356c9f-3445-4365-a0fb-3f8e18d613c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_f6733d5a-6c21-4618-a45d-aa7a4d87752a" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_c0356c9f-3445-4365-a0fb-3f8e18d613c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_c0356c9f-3445-4365-a0fb-3f8e18d613c5" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_c90fac26-6ed1-489c-8ed8-3f8391e35a93" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_c90fac26-6ed1-489c-8ed8-3f8391e35a93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_7387f9fa-de03-4448-8e88-50e055ce42b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_7387f9fa-de03-4448-8e88-50e055ce42b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_fc55ceb6-beab-4647-bcf6-34d6cb856149" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_fc55ceb6-beab-4647-bcf6-34d6cb856149" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInOtherComprehensiveIncome_a9d4b8e7-de7c-40dc-a76c-f8843dde7f8c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInOtherComprehensiveIncome"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInOtherComprehensiveIncome_a9d4b8e7-de7c-40dc-a76c-f8843dde7f8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion_4ef83faf-a9d7-443a-a377-4878167d72fd" xlink:href="endp-20210331.xsd#endp_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:to="loc_endp_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion_4ef83faf-a9d7-443a-a377-4878167d72fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation_9703cacc-0d4e-4773-8f2e-fb6808fb3bff" xlink:href="endp-20210331.xsd#endp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:to="loc_endp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation_9703cacc-0d4e-4773-8f2e-fb6808fb3bff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_b6200044-7f93-49fa-b78c-f8f52bae73eb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_c9e8f0f7-cd66-46df-88cb-3610b924c249" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_b6200044-7f93-49fa-b78c-f8f52bae73eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/FairValueMeasurementsScheduleofFinancialAssetsMeasuredAtFairValueOnANonrecurringBasisDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#FairValueMeasurementsScheduleofFinancialAssetsMeasuredAtFairValueOnANonrecurringBasisDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/FairValueMeasurementsScheduleofFinancialAssetsMeasuredAtFairValueOnANonrecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_3ae4c555-1886-4c18-a535-52d911cbd51f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_bc575554-6bad-4cb3-9701-5cf0a7cee0c8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_3ae4c555-1886-4c18-a535-52d911cbd51f" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_bc575554-6bad-4cb3-9701-5cf0a7cee0c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_6113ca96-b68a-4b39-a4dd-f6710ce344cd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_bc575554-6bad-4cb3-9701-5cf0a7cee0c8" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_6113ca96-b68a-4b39-a4dd-f6710ce344cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_82e1718c-cf5c-489c-862d-ad0a93343715" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_6113ca96-b68a-4b39-a4dd-f6710ce344cd" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_82e1718c-cf5c-489c-862d-ad0a93343715" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputDiscountRateMember_fea11a1c-986d-4247-afee-93f1dcd31651" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputDiscountRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_82e1718c-cf5c-489c-862d-ad0a93343715" xlink:to="loc_us-gaap_MeasurementInputDiscountRateMember_fea11a1c-986d-4247-afee-93f1dcd31651" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e9e22c75-6237-4264-a655-ada68723eba8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_bc575554-6bad-4cb3-9701-5cf0a7cee0c8" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e9e22c75-6237-4264-a655-ada68723eba8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8c3e5c6f-ec6b-48ca-a58c-ad05127937c8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e9e22c75-6237-4264-a655-ada68723eba8" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8c3e5c6f-ec6b-48ca-a58c-ad05127937c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_cc9d472b-1ad3-466e-9ee1-0696e6304f67" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8c3e5c6f-ec6b-48ca-a58c-ad05127937c8" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_cc9d472b-1ad3-466e-9ee1-0696e6304f67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_9577cec0-f82b-4b98-83d7-c98fd7f10d71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8c3e5c6f-ec6b-48ca-a58c-ad05127937c8" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_9577cec0-f82b-4b98-83d7-c98fd7f10d71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_a950f3c4-02bf-4b4b-a3b1-fe437d3c72ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8c3e5c6f-ec6b-48ca-a58c-ad05127937c8" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_a950f3c4-02bf-4b4b-a3b1-fe437d3c72ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_f3a69bf6-a82f-474b-979c-5d91cd62fa7f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_bc575554-6bad-4cb3-9701-5cf0a7cee0c8" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_f3a69bf6-a82f-474b-979c-5d91cd62fa7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_dc291a2d-afab-469e-9f87-fa26a02e0f78" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_f3a69bf6-a82f-474b-979c-5d91cd62fa7f" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_dc291a2d-afab-469e-9f87-fa26a02e0f78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsNonrecurringMember_81f5459f-e418-43be-9614-e798e976654e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsNonrecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_dc291a2d-afab-469e-9f87-fa26a02e0f78" xlink:to="loc_us-gaap_FairValueMeasurementsNonrecurringMember_81f5459f-e418-43be-9614-e798e976654e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80f96fb6-841e-4783-b81e-dad3d29e3c7c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_bc575554-6bad-4cb3-9701-5cf0a7cee0c8" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80f96fb6-841e-4783-b81e-dad3d29e3c7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_5a619d3d-8961-4031-bf30-c03f55219b68" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80f96fb6-841e-4783-b81e-dad3d29e3c7c" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_5a619d3d-8961-4031-bf30-c03f55219b68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsFairValueDisclosure_b4665574-e8e2-4a95-bea2-fd0fb1e19c9a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_5a619d3d-8961-4031-bf30-c03f55219b68" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsFairValueDisclosure_b4665574-e8e2-4a95-bea2-fd0fb1e19c9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentFairValueDisclosure_2b215f26-3ab0-4977-a644-8f9021295307" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_5a619d3d-8961-4031-bf30-c03f55219b68" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentFairValueDisclosure_2b215f26-3ab0-4977-a644-8f9021295307" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_22b32e0d-c389-47c7-852c-f0a298b01874" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_5a619d3d-8961-4031-bf30-c03f55219b68" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_22b32e0d-c389-47c7-852c-f0a298b01874" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_4d0e2b02-5a44-48ab-9d49-b261170e58b6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80f96fb6-841e-4783-b81e-dad3d29e3c7c" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_4d0e2b02-5a44-48ab-9d49-b261170e58b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TangibleAssetImpairmentCharges_90e7d625-5d3b-45e8-b016-5d51d634799e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TangibleAssetImpairmentCharges"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80f96fb6-841e-4783-b81e-dad3d29e3c7c" xlink:to="loc_us-gaap_TangibleAssetImpairmentCharges_90e7d625-5d3b-45e8-b016-5d51d634799e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_c62a1930-efba-41af-b37a-29c116f17dc6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80f96fb6-841e-4783-b81e-dad3d29e3c7c" xlink:to="loc_us-gaap_AssetImpairmentCharges_c62a1930-efba-41af-b37a-29c116f17dc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput_3fd301c3-b019-410c-a617-9ca5e0563e6f" xlink:href="endp-20210331.xsd#endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80f96fb6-841e-4783-b81e-dad3d29e3c7c" xlink:to="loc_endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput_3fd301c3-b019-410c-a617-9ca5e0563e6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/Inventories" xlink:type="simple" xlink:href="endp-20210331.xsd#Inventories"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/Inventories" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_d523c863-8ee2-4384-8478-66bd64b8ee7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureTextBlock_27512745-24b6-4155-9d24-728e5fbadfd8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_d523c863-8ee2-4384-8478-66bd64b8ee7a" xlink:to="loc_us-gaap_InventoryDisclosureTextBlock_27512745-24b6-4155-9d24-728e5fbadfd8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/InventoriesTables" xlink:type="simple" xlink:href="endp-20210331.xsd#InventoriesTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/InventoriesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_e23214d3-6b6c-486b-9370-d3c8cacd6001" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_2be942a5-d095-4aed-921a-af8f6cbf7910" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_e23214d3-6b6c-486b-9370-d3c8cacd6001" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_2be942a5-d095-4aed-921a-af8f6cbf7910" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/InventoriesDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#InventoriesDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_fc7581ba-ed81-4029-854c-27416eff2251" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_06015074-c680-4b75-b3ab-84c72b334cfd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_fc7581ba-ed81-4029-854c-27416eff2251" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_06015074-c680-4b75-b3ab-84c72b334cfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_24c363c4-7a56-474a-8ae4-4808312b5689" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_fc7581ba-ed81-4029-854c-27416eff2251" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_24c363c4-7a56-474a-8ae4-4808312b5689" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_19936d34-23e4-4db0-8ebb-7119b73fe41f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_fc7581ba-ed81-4029-854c-27416eff2251" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_19936d34-23e4-4db0-8ebb-7119b73fe41f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_a9f8e283-1849-4502-ae11-7bd37e34a02c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_fc7581ba-ed81-4029-854c-27416eff2251" xlink:to="loc_us-gaap_InventoryNet_a9f8e283-1849-4502-ae11-7bd37e34a02c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_eaeb5561-ec92-4c87-ba29-90260477237c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_fc7581ba-ed81-4029-854c-27416eff2251" xlink:to="loc_us-gaap_InventoryNoncurrent_eaeb5561-ec92-4c87-ba29-90260477237c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_InventoryNotYetAvailableForSaleNet_937d72e4-f2cf-4dbc-bc64-539b7dfa3540" xlink:href="endp-20210331.xsd#endp_InventoryNotYetAvailableForSaleNet"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_fc7581ba-ed81-4029-854c-27416eff2251" xlink:to="loc_endp_InventoryNotYetAvailableForSaleNet_937d72e4-f2cf-4dbc-bc64-539b7dfa3540" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/Leases" xlink:type="simple" xlink:href="endp-20210331.xsd#Leases"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/Leases" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_8d19b73e-3d39-4eb4-8063-e120362bc5b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeasesTextBlock_72e7a40e-22a9-408b-8b24-30458bed387b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeasesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_8d19b73e-3d39-4eb4-8063-e120362bc5b7" xlink:to="loc_us-gaap_LesseeOperatingLeasesTextBlock_72e7a40e-22a9-408b-8b24-30458bed387b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeFinanceLeasesTextBlock_be19e98a-37a1-44e8-acb7-cc58083b2663" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeFinanceLeasesTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_8d19b73e-3d39-4eb4-8063-e120362bc5b7" xlink:to="loc_us-gaap_LesseeFinanceLeasesTextBlock_be19e98a-37a1-44e8-acb7-cc58083b2663" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/LeasesTables" xlink:type="simple" xlink:href="endp-20210331.xsd#LeasesTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/LeasesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_91c596cd-a1b2-4e99-a0e6-4a2d5d932beb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AssetsAndLiabilitiesLesseeTableTextBlock_59bb2e3f-3147-44e8-b6ec-c059033e7f8f" xlink:href="endp-20210331.xsd#endp_AssetsAndLiabilitiesLesseeTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_91c596cd-a1b2-4e99-a0e6-4a2d5d932beb" xlink:to="loc_endp_AssetsAndLiabilitiesLesseeTableTextBlock_59bb2e3f-3147-44e8-b6ec-c059033e7f8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCostTableTextBlock_afd6cc4f-f23d-4b75-9fce-3b6d88879a93" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseCostTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_91c596cd-a1b2-4e99-a0e6-4a2d5d932beb" xlink:to="loc_us-gaap_LeaseCostTableTextBlock_afd6cc4f-f23d-4b75-9fce-3b6d88879a93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/LeasesAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#LeasesAssetsandLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/LeasesAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_530c3034-aebc-49bd-babc-a27c4f86d445" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsNoncurrentAbstract_08165013-2cb4-49ff-b88e-ec3ee48602b2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsNoncurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_530c3034-aebc-49bd-babc-a27c4f86d445" xlink:to="loc_us-gaap_AssetsNoncurrentAbstract_08165013-2cb4-49ff-b88e-ec3ee48602b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_239c14aa-9cd1-4f03-93a0-de18284030c8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_08165013-2cb4-49ff-b88e-ec3ee48602b2" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_239c14aa-9cd1-4f03-93a0-de18284030c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_b8de6284-203b-4192-8b28-dcf5560a9486" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_08165013-2cb4-49ff-b88e-ec3ee48602b2" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_b8de6284-203b-4192-8b28-dcf5560a9486" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_73e8a83a-a9ab-49a7-a6b7-2870a05fbcad" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_08165013-2cb4-49ff-b88e-ec3ee48602b2" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_73e8a83a-a9ab-49a7-a6b7-2870a05fbcad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LeaseRightofUseAsset_b335756e-8476-4910-8d3a-1e26bfd72bc4" xlink:href="endp-20210331.xsd#endp_LeaseRightofUseAsset"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_08165013-2cb4-49ff-b88e-ec3ee48602b2" xlink:to="loc_endp_LeaseRightofUseAsset_b335756e-8476-4910-8d3a-1e26bfd72bc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrentAbstract_d3db6650-b750-4e5a-baed-e64310386a83" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesNoncurrentAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_530c3034-aebc-49bd-babc-a27c4f86d445" xlink:to="loc_us-gaap_LiabilitiesNoncurrentAbstract_d3db6650-b750-4e5a-baed-e64310386a83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_44a525f0-01e0-4359-89b0-c63dec767114" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_d3db6650-b750-4e5a-baed-e64310386a83" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_44a525f0-01e0-4359-89b0-c63dec767114" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3f1bafcb-6350-4ca7-81d3-d87e625bbd73" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_d3db6650-b750-4e5a-baed-e64310386a83" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3f1bafcb-6350-4ca7-81d3-d87e625bbd73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_ddb50f28-3979-4a4a-91d0-e8816b6db0a1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_d3db6650-b750-4e5a-baed-e64310386a83" xlink:to="loc_us-gaap_OperatingLeaseLiability_ddb50f28-3979-4a4a-91d0-e8816b6db0a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAndLiabilitiesLesseeAbstract_40e702f8-f58e-444e-ba8d-cdea2633d261" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsAndLiabilitiesLesseeAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_530c3034-aebc-49bd-babc-a27c4f86d445" xlink:to="loc_us-gaap_AssetsAndLiabilitiesLesseeAbstract_40e702f8-f58e-444e-ba8d-cdea2633d261" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_799cd518-f356-4987-8f63-40dccb8e0953" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAndLiabilitiesLesseeAbstract_40e702f8-f58e-444e-ba8d-cdea2633d261" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_799cd518-f356-4987-8f63-40dccb8e0953" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_2e4ad810-7554-4c0f-9d33-1377dcfac0fc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAndLiabilitiesLesseeAbstract_40e702f8-f58e-444e-ba8d-cdea2633d261" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_2e4ad810-7554-4c0f-9d33-1377dcfac0fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrentStatementOfFinancialPositionExtensibleList_e64d7f32-1b1e-4f21-af46-020ff72b89b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrentStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAndLiabilitiesLesseeAbstract_40e702f8-f58e-444e-ba8d-cdea2633d261" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrentStatementOfFinancialPositionExtensibleList_e64d7f32-1b1e-4f21-af46-020ff72b89b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_1ab451d9-b7e9-45b0-a611-a9f898195ce5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAndLiabilitiesLesseeAbstract_40e702f8-f58e-444e-ba8d-cdea2633d261" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_1ab451d9-b7e9-45b0-a611-a9f898195ce5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_9cf22107-4c03-4ab4-833a-1fdff0aa1237" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAndLiabilitiesLesseeAbstract_40e702f8-f58e-444e-ba8d-cdea2633d261" xlink:to="loc_us-gaap_FinanceLeaseLiability_9cf22107-4c03-4ab4-833a-1fdff0aa1237" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/LeasesComponentsofLeaseExpenseDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#LeasesComponentsofLeaseExpenseDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/LeasesComponentsofLeaseExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_ceb691b1-ff7b-4087-b108-07ad7c49c232" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_708bea97-b3b7-42d5-baeb-41d3cd2835ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseCost"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_ceb691b1-ff7b-4087-b108-07ad7c49c232" xlink:to="loc_us-gaap_OperatingLeaseCost_708bea97-b3b7-42d5-baeb-41d3cd2835ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCostAbstract_07164799-e7fb-470d-b102-9a58660efdca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseCostAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_ceb691b1-ff7b-4087-b108-07ad7c49c232" xlink:to="loc_us-gaap_LeaseCostAbstract_07164799-e7fb-470d-b102-9a58660efdca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_6236d3d3-2cd1-4a60-b467-22e5e6a92b47" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeaseCostAbstract_07164799-e7fb-470d-b102-9a58660efdca" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_6236d3d3-2cd1-4a60-b467-22e5e6a92b47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_b9a34df1-7073-4a96-bbb5-4b8a50f8e382" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseInterestExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeaseCostAbstract_07164799-e7fb-470d-b102-9a58660efdca" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_b9a34df1-7073-4a96-bbb5-4b8a50f8e382" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesLeaseIncomeAbstract_bc503f1c-b96c-4d46-b544-1f4fd0599cb9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesLeaseIncomeAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_ceb691b1-ff7b-4087-b108-07ad7c49c232" xlink:to="loc_us-gaap_OperatingLeasesLeaseIncomeAbstract_bc503f1c-b96c-4d46-b544-1f4fd0599cb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_0e1ff212-0c5b-40ae-b59b-5393da598640" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_VariableLeaseCost"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesLeaseIncomeAbstract_bc503f1c-b96c-4d46-b544-1f4fd0599cb9" xlink:to="loc_us-gaap_VariableLeaseCost_0e1ff212-0c5b-40ae-b59b-5393da598640" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubleaseIncome_980e83df-569d-45f9-ad01-e168753b5cc2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubleaseIncome"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesLeaseIncomeAbstract_bc503f1c-b96c-4d46-b544-1f4fd0599cb9" xlink:to="loc_us-gaap_SubleaseIncome_980e83df-569d-45f9-ad01-e168753b5cc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_9f6f2b43-3414-45c5-a493-2c4d1b65c02c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_ceb691b1-ff7b-4087-b108-07ad7c49c232" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_9f6f2b43-3414-45c5-a493-2c4d1b65c02c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_046bb8e4-be3c-42dd-a909-1cdca2235449" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_9f6f2b43-3414-45c5-a493-2c4d1b65c02c" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_046bb8e4-be3c-42dd-a909-1cdca2235449" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_f4b0b256-b924-4716-8df2-1325ae1427bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_046bb8e4-be3c-42dd-a909-1cdca2235449" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_f4b0b256-b924-4716-8df2-1325ae1427bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_0b534690-9a4f-4d87-9394-9117d9a01627" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfSalesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_f4b0b256-b924-4716-8df2-1325ae1427bf" xlink:to="loc_us-gaap_CostOfSalesMember_0b534690-9a4f-4d87-9394-9117d9a01627" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_ac15ade0-5e2f-4fbc-aa9e-c1c9f55362f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_f4b0b256-b924-4716-8df2-1325ae1427bf" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_ac15ade0-5e2f-4fbc-aa9e-c1c9f55362f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_034d6661-bd16-4f88-9c49-97ad76225477" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_f4b0b256-b924-4716-8df2-1325ae1427bf" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_034d6661-bd16-4f88-9c49-97ad76225477" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_98d9277b-30bf-48f3-914f-6db2ef86f4ba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_9f6f2b43-3414-45c5-a493-2c4d1b65c02c" xlink:to="loc_us-gaap_LesseeLeaseDescriptionLineItems_98d9277b-30bf-48f3-914f-6db2ef86f4ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_599a03f9-0059-4074-a5b1-7cead4d8d154" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseCost"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_98d9277b-30bf-48f3-914f-6db2ef86f4ba" xlink:to="loc_us-gaap_LeaseCost_599a03f9-0059-4074-a5b1-7cead4d8d154" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/LeasesCashFlowandSupplementalNoncashInformationDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#LeasesCashFlowandSupplementalNoncashInformationDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/LeasesCashFlowandSupplementalNoncashInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_e306f085-3795-43bf-8afa-cd2cc2bf6537" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_CashFlowLesseeAbstract_fc0918a9-488b-4f36-98ea-2e4b75e21c8a" xlink:href="endp-20210331.xsd#endp_CashFlowLesseeAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_e306f085-3795-43bf-8afa-cd2cc2bf6537" xlink:to="loc_endp_CashFlowLesseeAbstract_fc0918a9-488b-4f36-98ea-2e4b75e21c8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_f7ba8874-4b54-459c-9e1f-5f3de5f02f0f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasePayments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_CashFlowLesseeAbstract_fc0918a9-488b-4f36-98ea-2e4b75e21c8a" xlink:to="loc_us-gaap_OperatingLeasePayments_f7ba8874-4b54-459c-9e1f-5f3de5f02f0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestPaymentOnLiability_43563a40-faa9-4076-9b4b-dd1e5901be07" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseInterestPaymentOnLiability"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_CashFlowLesseeAbstract_fc0918a9-488b-4f36-98ea-2e4b75e21c8a" xlink:to="loc_us-gaap_FinanceLeaseInterestPaymentOnLiability_43563a40-faa9-4076-9b4b-dd1e5901be07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_512b7b60-8e15-420d-93e8-327f4df49644" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_CashFlowLesseeAbstract_fc0918a9-488b-4f36-98ea-2e4b75e21c8a" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_512b7b60-8e15-420d-93e8-327f4df49644" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangibles" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangibles"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangibles" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_2c4780ad-23ad-4ad8-81bb-a2fa3265d412" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock_e64bc2f5-9676-4ff8-a868-cd9fddfebfe1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_2c4780ad-23ad-4ad8-81bb-a2fa3265d412" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock_e64bc2f5-9676-4ff8-a868-cd9fddfebfe1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangiblesTables" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangiblesTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangiblesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4211b9dc-c04e-4227-882a-2e2897fd8840" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTextBlock_b04c2b99-e3ef-4fcc-95f7-bb58a090c8e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfGoodwillTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4211b9dc-c04e-4227-882a-2e2897fd8840" xlink:to="loc_us-gaap_ScheduleOfGoodwillTextBlock_b04c2b99-e3ef-4fcc-95f7-bb58a090c8e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_3982996c-21ba-4005-a0b2-23372ee7fb09" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4211b9dc-c04e-4227-882a-2e2897fd8840" xlink:to="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_3982996c-21ba-4005-a0b2-23372ee7fb09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_825afd6b-8131-4a2e-acfc-66f67292cefa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4211b9dc-c04e-4227-882a-2e2897fd8840" xlink:to="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_825afd6b-8131-4a2e-acfc-66f67292cefa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock_3dbe28aa-905c-4a74-b5f2-02caeda7f8fb" xlink:href="endp-20210331.xsd#endp_ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4211b9dc-c04e-4227-882a-2e2897fd8840" xlink:to="loc_endp_ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock_3dbe28aa-905c-4a74-b5f2-02caeda7f8fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangiblesScheduleofChangesintheCarryingAmountofGoodwillDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangiblesScheduleofChangesintheCarryingAmountofGoodwillDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangiblesScheduleofChangesintheCarryingAmountofGoodwillDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_62c3044d-8572-498b-a821-a23fc2b9191c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d08c86db-9979-4ebf-bd34-00e9150b4497" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_62c3044d-8572-498b-a821-a23fc2b9191c" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d08c86db-9979-4ebf-bd34-00e9150b4497" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_7caaafcd-6ad3-4b45-b88e-d321207ad96e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d08c86db-9979-4ebf-bd34-00e9150b4497" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_7caaafcd-6ad3-4b45-b88e-d321207ad96e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_9146f97b-4c58-4d2a-b94e-5dade0ed2f13" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_7caaafcd-6ad3-4b45-b88e-d321207ad96e" xlink:to="loc_us-gaap_SegmentDomain_9146f97b-4c58-4d2a-b94e-5dade0ed2f13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_BrandedPharmaceuticalsSegmentMember_1066f33d-c6d4-434e-93e7-16b11c36bd24" xlink:href="endp-20210331.xsd#endp_BrandedPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9146f97b-4c58-4d2a-b94e-5dade0ed2f13" xlink:to="loc_endp_BrandedPharmaceuticalsSegmentMember_1066f33d-c6d4-434e-93e7-16b11c36bd24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SterileInjectablesSegmentMember_5fcea6dc-388a-4f69-9929-a9a440461f62" xlink:href="endp-20210331.xsd#endp_SterileInjectablesSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9146f97b-4c58-4d2a-b94e-5dade0ed2f13" xlink:to="loc_endp_SterileInjectablesSegmentMember_5fcea6dc-388a-4f69-9929-a9a440461f62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_GenericPharmaceuticalsSegmentMember_269efd42-4289-4e07-a714-3666a8315e78" xlink:href="endp-20210331.xsd#endp_GenericPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9146f97b-4c58-4d2a-b94e-5dade0ed2f13" xlink:to="loc_endp_GenericPharmaceuticalsSegmentMember_269efd42-4289-4e07-a714-3666a8315e78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_InternationalPharmaceuticalsSegmentMember_23656d95-ac2c-4b47-897b-75b2e8f242e8" xlink:href="endp-20210331.xsd#endp_InternationalPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9146f97b-4c58-4d2a-b94e-5dade0ed2f13" xlink:to="loc_endp_InternationalPharmaceuticalsSegmentMember_23656d95-ac2c-4b47-897b-75b2e8f242e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_f2f7fd33-4776-4c57-b288-68557dffbbb5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_d08c86db-9979-4ebf-bd34-00e9150b4497" xlink:to="loc_us-gaap_SegmentReportingInformationLineItems_f2f7fd33-4776-4c57-b288-68557dffbbb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_5012ac92-602e-4eca-a27b-b35906e4dfc7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f2f7fd33-4776-4c57-b288-68557dffbbb5" xlink:to="loc_us-gaap_GoodwillRollForward_5012ac92-602e-4eca-a27b-b35906e4dfc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_27fbace9-7a27-4ff3-9295-de09b93e801c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_5012ac92-602e-4eca-a27b-b35906e4dfc7" xlink:to="loc_us-gaap_Goodwill_27fbace9-7a27-4ff3-9295-de09b93e801c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_9f71b04f-c2d8-409e-96f3-44ac11719eea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillRollForward_5012ac92-602e-4eca-a27b-b35906e4dfc7" xlink:to="loc_us-gaap_Goodwill_9f71b04f-c2d8-409e-96f3-44ac11719eea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangiblesAccumulatedImpairmentDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangiblesAccumulatedImpairmentDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangiblesAccumulatedImpairmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_85cf10de-f5bc-40b3-bdf5-d8ee9c339135" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_f4beb922-9e3e-4e93-82d7-34f2d3293b90" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_85cf10de-f5bc-40b3-bdf5-d8ee9c339135" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_f4beb922-9e3e-4e93-82d7-34f2d3293b90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_25023eac-498d-4c72-9061-b23e29152334" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_f4beb922-9e3e-4e93-82d7-34f2d3293b90" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_25023eac-498d-4c72-9061-b23e29152334" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_50f1d8a0-cf81-45dd-9dac-dec0bc11e64f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_25023eac-498d-4c72-9061-b23e29152334" xlink:to="loc_us-gaap_SegmentDomain_50f1d8a0-cf81-45dd-9dac-dec0bc11e64f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_BrandedPharmaceuticalsSegmentMember_1ab16d87-c15d-40f4-a6dc-cf726f3c9114" xlink:href="endp-20210331.xsd#endp_BrandedPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_50f1d8a0-cf81-45dd-9dac-dec0bc11e64f" xlink:to="loc_endp_BrandedPharmaceuticalsSegmentMember_1ab16d87-c15d-40f4-a6dc-cf726f3c9114" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SterileInjectablesSegmentMember_acfa9fc1-81f4-4251-b968-68b08b114d7d" xlink:href="endp-20210331.xsd#endp_SterileInjectablesSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_50f1d8a0-cf81-45dd-9dac-dec0bc11e64f" xlink:to="loc_endp_SterileInjectablesSegmentMember_acfa9fc1-81f4-4251-b968-68b08b114d7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_GenericPharmaceuticalsSegmentMember_8279670e-d9ff-40e0-837a-3dfbf6b6ea30" xlink:href="endp-20210331.xsd#endp_GenericPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_50f1d8a0-cf81-45dd-9dac-dec0bc11e64f" xlink:to="loc_endp_GenericPharmaceuticalsSegmentMember_8279670e-d9ff-40e0-837a-3dfbf6b6ea30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_InternationalPharmaceuticalsSegmentMember_1f762b9a-4e51-477a-8a1f-ff285bc40652" xlink:href="endp-20210331.xsd#endp_InternationalPharmaceuticalsSegmentMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_50f1d8a0-cf81-45dd-9dac-dec0bc11e64f" xlink:to="loc_endp_InternationalPharmaceuticalsSegmentMember_1f762b9a-4e51-477a-8a1f-ff285bc40652" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_e8da7daa-d741-4515-89f0-5737dc9f1a79" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_f4beb922-9e3e-4e93-82d7-34f2d3293b90" xlink:to="loc_us-gaap_GoodwillLineItems_e8da7daa-d741-4515-89f0-5737dc9f1a79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_e7f602a4-b650-4849-80be-924485ca56aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairedAccumulatedImpairmentLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_e8da7daa-d741-4515-89f0-5737dc9f1a79" xlink:to="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_e7f602a4-b650-4849-80be-924485ca56aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangiblesScheduleofOtherIntangibleAssetsDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangiblesScheduleofOtherIntangibleAssetsDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangiblesScheduleofOtherIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_87ebc300-7fcc-4c1c-bb59-a2c02f168262" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ScheduleOfGoodwillAndOtherIntangiblesTable_94a829d7-8347-4435-a2aa-353614a7e720" xlink:href="endp-20210331.xsd#endp_ScheduleOfGoodwillAndOtherIntangiblesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_87ebc300-7fcc-4c1c-bb59-a2c02f168262" xlink:to="loc_endp_ScheduleOfGoodwillAndOtherIntangiblesTable_94a829d7-8347-4435-a2aa-353614a7e720" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_1fb3a404-b909-43f2-80c2-456d46b65621" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_ScheduleOfGoodwillAndOtherIntangiblesTable_94a829d7-8347-4435-a2aa-353614a7e720" xlink:to="loc_srt_RangeAxis_1fb3a404-b909-43f2-80c2-456d46b65621" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_1097dae5-0020-4714-aa92-28ae106e46dc" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_1fb3a404-b909-43f2-80c2-456d46b65621" xlink:to="loc_srt_RangeMember_1097dae5-0020-4714-aa92-28ae106e46dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_WeightedAverageMember_bc2d4db1-bf62-4de5-b9a7-3f94508fa78c" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_WeightedAverageMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_1097dae5-0020-4714-aa92-28ae106e46dc" xlink:to="loc_srt_WeightedAverageMember_bc2d4db1-bf62-4de5-b9a7-3f94508fa78c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_d45e9e7b-01e9-413c-b5a2-2a55cd823f7b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_ScheduleOfGoodwillAndOtherIntangiblesTable_94a829d7-8347-4435-a2aa-353614a7e720" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_d45e9e7b-01e9-413c-b5a2-2a55cd823f7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f70304ab-1cbd-444e-b45c-59acf456823e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_d45e9e7b-01e9-413c-b5a2-2a55cd823f7b" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f70304ab-1cbd-444e-b45c-59acf456823e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InProcessResearchAndDevelopmentMember_e6c1d03b-b06a-4069-a426-6b6dc27a9e46" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InProcessResearchAndDevelopmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f70304ab-1cbd-444e-b45c-59acf456823e" xlink:to="loc_us-gaap_InProcessResearchAndDevelopmentMember_e6c1d03b-b06a-4069-a426-6b6dc27a9e46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_c056d307-4906-4ae8-8e8f-a04a7159646e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_ScheduleOfGoodwillAndOtherIntangiblesTable_94a829d7-8347-4435-a2aa-353614a7e720" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_c056d307-4906-4ae8-8e8f-a04a7159646e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1feda1cd-eba0-470b-8dbf-9e895e341fae" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_c056d307-4906-4ae8-8e8f-a04a7159646e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1feda1cd-eba0-470b-8dbf-9e895e341fae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_f09eaa11-3452-4685-9f0b-4cdcbfb6157c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1feda1cd-eba0-470b-8dbf-9e895e341fae" xlink:to="loc_us-gaap_LicensingAgreementsMember_f09eaa11-3452-4685-9f0b-4cdcbfb6157c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember_a49b3bbf-4108-4b1c-a38f-24275c23e158" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TradeNamesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1feda1cd-eba0-470b-8dbf-9e895e341fae" xlink:to="loc_us-gaap_TradeNamesMember_a49b3bbf-4108-4b1c-a38f-24275c23e158" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_15cb76d5-36fa-4e94-9530-e4a8da500e52" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1feda1cd-eba0-470b-8dbf-9e895e341fae" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_15cb76d5-36fa-4e94-9530-e4a8da500e52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_OtherIntangibleAssetsLineItems_f98959b3-0764-4421-ae94-a73794b83297" xlink:href="endp-20210331.xsd#endp_OtherIntangibleAssetsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_ScheduleOfGoodwillAndOtherIntangiblesTable_94a829d7-8347-4435-a2aa-353614a7e720" xlink:to="loc_endp_OtherIntangibleAssetsLineItems_f98959b3-0764-4421-ae94-a73794b83297" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_OtherIntangibleAssetsCostBasisAbstract_3c8c5b39-5512-432e-ac53-422e2bf61dd5" xlink:href="endp-20210331.xsd#endp_OtherIntangibleAssetsCostBasisAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_OtherIntangibleAssetsLineItems_f98959b3-0764-4421-ae94-a73794b83297" xlink:to="loc_endp_OtherIntangibleAssetsCostBasisAbstract_3c8c5b39-5512-432e-ac53-422e2bf61dd5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_a17d3606-b74e-405d-9302-3ddf2012513c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_OtherIntangibleAssetsCostBasisAbstract_3c8c5b39-5512-432e-ac53-422e2bf61dd5" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_a17d3606-b74e-405d-9302-3ddf2012513c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_2acbdc52-1f85-4074-bc7d-b53b5e99ca10" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_a17d3606-b74e-405d-9302-3ddf2012513c" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_2acbdc52-1f85-4074-bc7d-b53b5e99ca10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefinitelivedIntangibleAssetsAcquired_533d71ea-2b93-4d90-9057-0a39138ecbb3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefinitelivedIntangibleAssetsAcquired"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_a17d3606-b74e-405d-9302-3ddf2012513c" xlink:to="loc_us-gaap_IndefinitelivedIntangibleAssetsAcquired_533d71ea-2b93-4d90-9057-0a39138ecbb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_773cb293-4ef1-48bb-a29a-737d98949bc5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_a17d3606-b74e-405d-9302-3ddf2012513c" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_773cb293-4ef1-48bb-a29a-737d98949bc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss_d670f206-7074-47fe-af4e-75d85622bdae" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_a17d3606-b74e-405d-9302-3ddf2012513c" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss_d670f206-7074-47fe-af4e-75d85622bdae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_8e2a679f-0feb-4f3f-b4e3-bba8a9b87fe9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsRollForward_a17d3606-b74e-405d-9302-3ddf2012513c" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_8e2a679f-0feb-4f3f-b4e3-bba8a9b87fe9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_658fa8db-9c8b-4fe3-9608-7de8ffafa11a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_OtherIntangibleAssetsCostBasisAbstract_3c8c5b39-5512-432e-ac53-422e2bf61dd5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_658fa8db-9c8b-4fe3-9608-7de8ffafa11a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_8dd64aa7-1002-4595-928c-64bd398bac7b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_658fa8db-9c8b-4fe3-9608-7de8ffafa11a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_8dd64aa7-1002-4595-928c-64bd398bac7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinitelivedIntangibleAssetsAcquired1_de322fa0-aa0c-44f6-a0aa-901add74110c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinitelivedIntangibleAssetsAcquired1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_658fa8db-9c8b-4fe3-9608-7de8ffafa11a" xlink:to="loc_us-gaap_FinitelivedIntangibleAssetsAcquired1_de322fa0-aa0c-44f6-a0aa-901add74110c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_c7a65dc8-c427-4724-95d0-c13cacf99974" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_658fa8db-9c8b-4fe3-9608-7de8ffafa11a" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_c7a65dc8-c427-4724-95d0-c13cacf99974" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss_de2999d9-9a1a-41d9-8d25-c3c613f72d8d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_658fa8db-9c8b-4fe3-9608-7de8ffafa11a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsForeignCurrencyTranslationGainLoss_de2999d9-9a1a-41d9-8d25-c3c613f72d8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_69c01efd-186a-4240-ba6a-bf8bf8328de5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_658fa8db-9c8b-4fe3-9608-7de8ffafa11a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_69c01efd-186a-4240-ba6a-bf8bf8328de5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_IntangibleAssetsGrossRollForward_9a8909bb-bd45-45e6-bec7-61583827fcb1" xlink:href="endp-20210331.xsd#endp_IntangibleAssetsGrossRollForward"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_OtherIntangibleAssetsCostBasisAbstract_3c8c5b39-5512-432e-ac53-422e2bf61dd5" xlink:to="loc_endp_IntangibleAssetsGrossRollForward_9a8909bb-bd45-45e6-bec7-61583827fcb1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_437bd280-cfcb-4039-8719-2c72b7113d55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_IntangibleAssetsGrossRollForward_9a8909bb-bd45-45e6-bec7-61583827fcb1" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_437bd280-cfcb-4039-8719-2c72b7113d55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_IntangibleAssetsAcquired_a1601ab4-354c-40ed-9d69-e8ad942de9a0" xlink:href="endp-20210331.xsd#endp_IntangibleAssetsAcquired"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_IntangibleAssetsGrossRollForward_9a8909bb-bd45-45e6-bec7-61583827fcb1" xlink:to="loc_endp_IntangibleAssetsAcquired_a1601ab4-354c-40ed-9d69-e8ad942de9a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_c65b3d31-39e6-4d3b-9ac6-e37881d0962d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_IntangibleAssetsGrossRollForward_9a8909bb-bd45-45e6-bec7-61583827fcb1" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_c65b3d31-39e6-4d3b-9ac6-e37881d0962d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_IntangibleAssetsForeignCurrencyTranslationGainLoss_d07638c3-008c-4b2d-86e4-9e03f5e18ad4" xlink:href="endp-20210331.xsd#endp_IntangibleAssetsForeignCurrencyTranslationGainLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_IntangibleAssetsGrossRollForward_9a8909bb-bd45-45e6-bec7-61583827fcb1" xlink:to="loc_endp_IntangibleAssetsForeignCurrencyTranslationGainLoss_d07638c3-008c-4b2d-86e4-9e03f5e18ad4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_c9778c07-65e7-4caa-b873-a6793cdf2ac6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_IntangibleAssetsGrossRollForward_9a8909bb-bd45-45e6-bec7-61583827fcb1" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_c9778c07-65e7-4caa-b873-a6793cdf2ac6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward_6481f9ce-ff9d-4b5f-b9c5-46daedd7f0fa" xlink:href="endp-20210331.xsd#endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_OtherIntangibleAssetsLineItems_f98959b3-0764-4421-ae94-a73794b83297" xlink:to="loc_endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward_6481f9ce-ff9d-4b5f-b9c5-46daedd7f0fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_718b7f71-9de3-4eeb-a38f-0bf2241480dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward_6481f9ce-ff9d-4b5f-b9c5-46daedd7f0fa" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_718b7f71-9de3-4eeb-a38f-0bf2241480dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedPeriodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_46a4adc3-8cdd-4851-b90b-5524c129f553" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward_6481f9ce-ff9d-4b5f-b9c5-46daedd7f0fa" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_46a4adc3-8cdd-4851-b90b-5524c129f553" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ImpairmentofIntangibleAssetsFinitelivedEffectOnAccumulatedAmortization_d82c0dbe-966d-46a2-9c90-cb2f074836e1" xlink:href="endp-20210331.xsd#endp_ImpairmentofIntangibleAssetsFinitelivedEffectOnAccumulatedAmortization"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward_6481f9ce-ff9d-4b5f-b9c5-46daedd7f0fa" xlink:to="loc_endp_ImpairmentofIntangibleAssetsFinitelivedEffectOnAccumulatedAmortization_d82c0dbe-966d-46a2-9c90-cb2f074836e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization_8708799d-6f87-4d57-b76a-62db9e9b37b8" xlink:href="endp-20210331.xsd#endp_FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward_6481f9ce-ff9d-4b5f-b9c5-46daedd7f0fa" xlink:to="loc_endp_FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization_8708799d-6f87-4d57-b76a-62db9e9b37b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_f0c59928-302d-4d28-a9d4-15d81758ec59" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward_6481f9ce-ff9d-4b5f-b9c5-46daedd7f0fa" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_f0c59928-302d-4d28-a9d4-15d81758ec59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedPeriodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_c9aa2ef9-299a-433f-800b-ef90188a329d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_OtherIntangibleAssetsLineItems_f98959b3-0764-4421-ae94-a73794b83297" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_c9aa2ef9-299a-433f-800b-ef90188a329d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_f980d068-dc0b-4515-b832-36ff4966e7e0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_OtherIntangibleAssetsLineItems_f98959b3-0764-4421-ae94-a73794b83297" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_f980d068-dc0b-4515-b832-36ff4966e7e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangiblesOtherIntangiblesNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangiblesOtherIntangiblesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangiblesOtherIntangiblesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_2e7a400b-fad8-4d54-a871-f714d1ab6caf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_a39ccf6b-f117-43fd-a340-8b6f2d07ac55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_2e7a400b-fad8-4d54-a871-f714d1ab6caf" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_a39ccf6b-f117-43fd-a340-8b6f2d07ac55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangiblesScheduleofEstimatedAmortizationofIntangiblesDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangiblesScheduleofEstimatedAmortizationofIntangiblesDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangiblesScheduleofEstimatedAmortizationofIntangiblesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_72abc385-81c2-4649-8008-88ec3ade3bc4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_79ec4597-aa90-4ea8-91a9-83a9f56d719e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_72abc385-81c2-4649-8008-88ec3ade3bc4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_79ec4597-aa90-4ea8-91a9-83a9f56d719e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_49544b80-06ba-4cd9-97f5-899cfbb54292" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_72abc385-81c2-4649-8008-88ec3ade3bc4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_49544b80-06ba-4cd9-97f5-899cfbb54292" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_2fe5a678-e606-4305-b07f-cffdb42ac4a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_72abc385-81c2-4649-8008-88ec3ade3bc4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_2fe5a678-e606-4305-b07f-cffdb42ac4a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_ecd19926-0899-4242-9736-22934a10b0b6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_72abc385-81c2-4649-8008-88ec3ade3bc4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_ecd19926-0899-4242-9736-22934a10b0b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_a3a3aa1b-78b3-484a-afa7-ca96539a3de4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_72abc385-81c2-4649-8008-88ec3ade3bc4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_a3a3aa1b-78b3-484a-afa7-ca96539a3de4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangiblesScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangiblesScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangiblesScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_652f8228-eeed-4f47-ae28-d0efe713bee4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_0937f3ea-5b5b-4a91-8e74-6a93becf7448" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_652f8228-eeed-4f47-ae28-d0efe713bee4" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_0937f3ea-5b5b-4a91-8e74-6a93becf7448" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_02e8a071-62dd-4773-a264-1b073cd6c914" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_652f8228-eeed-4f47-ae28-d0efe713bee4" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_02e8a071-62dd-4773-a264-1b073cd6c914" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/GoodwillandOtherIntangiblesImpairmentsNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#GoodwillandOtherIntangiblesImpairmentsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/GoodwillandOtherIntangiblesImpairmentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_c129b134-1240-429c-8215-9a295dc9811a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_fa17191e-5303-49c9-bc5d-e5c162e88837" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_c129b134-1240-429c-8215-9a295dc9811a" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_fa17191e-5303-49c9-bc5d-e5c162e88837" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitAxis_4e720016-a4a9-4059-9791-94bdf88226cd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ReportingUnitAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_fa17191e-5303-49c9-bc5d-e5c162e88837" xlink:to="loc_us-gaap_ReportingUnitAxis_4e720016-a4a9-4059-9791-94bdf88226cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_48e5b037-5e90-4634-985e-fac46dd0c040" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ReportingUnitDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReportingUnitAxis_4e720016-a4a9-4059-9791-94bdf88226cd" xlink:to="loc_us-gaap_ReportingUnitDomain_48e5b037-5e90-4634-985e-fac46dd0c040" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_PaladinLabsInc.Member_691f211f-5bec-47f4-98e2-ba44fa76017e" xlink:href="endp-20210331.xsd#endp_PaladinLabsInc.Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReportingUnitDomain_48e5b037-5e90-4634-985e-fac46dd0c040" xlink:to="loc_endp_PaladinLabsInc.Member_691f211f-5bec-47f4-98e2-ba44fa76017e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_9be4547a-8f70-492b-a5d0-5b2cd2541936" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_fa17191e-5303-49c9-bc5d-e5c162e88837" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_9be4547a-8f70-492b-a5d0-5b2cd2541936" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_e4e7e380-8aee-4edc-be51-9c70c62e0fa0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_9be4547a-8f70-492b-a5d0-5b2cd2541936" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_e4e7e380-8aee-4edc-be51-9c70c62e0fa0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputDiscountRateMember_9d10fa97-a6a1-4440-b3f0-0d286d24c914" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MeasurementInputDiscountRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_e4e7e380-8aee-4edc-be51-9c70c62e0fa0" xlink:to="loc_us-gaap_MeasurementInputDiscountRateMember_9d10fa97-a6a1-4440-b3f0-0d286d24c914" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_966b12c3-1c11-4a9e-b2bc-d5becec70fb5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_fa17191e-5303-49c9-bc5d-e5c162e88837" xlink:to="loc_us-gaap_GoodwillLineItems_966b12c3-1c11-4a9e-b2bc-d5becec70fb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput_76f6dd43-3a1c-431b-ba9e-0216d2add71f" xlink:href="endp-20210331.xsd#endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_966b12c3-1c11-4a9e-b2bc-d5becec70fb5" xlink:to="loc_endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput_76f6dd43-3a1c-431b-ba9e-0216d2add71f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_6c9524c4-229b-4a62-a91e-85056353a7d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillLineItems_966b12c3-1c11-4a9e-b2bc-d5becec70fb5" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_6c9524c4-229b-4a62-a91e-85056353a7d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ContractAssetsandLiabilities" xlink:type="simple" xlink:href="endp-20210331.xsd#ContractAssetsandLiabilities"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/ContractAssetsandLiabilities" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_753e577c-b4ba-4c17-b8d7-7a3a61d0019a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_240fd5d6-cd5d-404d-b94d-e795378c3b50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_753e577c-b4ba-4c17-b8d7-7a3a61d0019a" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_240fd5d6-cd5d-404d-b94d-e795378c3b50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ContractAssetsandLiabilitiesTables" xlink:type="simple" xlink:href="endp-20210331.xsd#ContractAssetsandLiabilitiesTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/ContractAssetsandLiabilitiesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_694aa04d-c682-4932-be9c-1f5823b7ba03" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_940a0499-ecb6-4b9e-a9c3-6521aac2ff0d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_694aa04d-c682-4932-be9c-1f5823b7ba03" xlink:to="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_940a0499-ecb6-4b9e-a9c3-6521aac2ff0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ContractAssetsandLiabilitiesContractAssetsandContractLiabilitiesfromContractswithCustomersDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#ContractAssetsandLiabilitiesContractAssetsandContractLiabilitiesfromContractswithCustomersDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/ContractAssetsandLiabilitiesContractAssetsandContractLiabilitiesfromContractswithCustomersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNet_59b103d6-bdd5-4a9b-925e-a94882bb717a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerAssetNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_us-gaap_ContractWithCustomerAssetNet_59b103d6-bdd5-4a9b-925e-a94882bb717a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_ac76bac5-a3ac-450a-9170-15aca9707a1a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerAsset"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_ac76bac5-a3ac-450a-9170-15aca9707a1a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ContractWithCustomerAssetIncreaseDecreasePercentage_ac78dd0c-a07a-434d-926e-7590c71d660b" xlink:href="endp-20210331.xsd#endp_ContractWithCustomerAssetIncreaseDecreasePercentage"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_endp_ContractWithCustomerAssetIncreaseDecreasePercentage_ac78dd0c-a07a-434d-926e-7590c71d660b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_87cff86a-18af-4852-97b4-c6dc51a57c9a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_us-gaap_ContractWithCustomerLiability_87cff86a-18af-4852-97b4-c6dc51a57c9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_c11722d7-5979-4edd-a33e-5948104e7f49" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_c11722d7-5979-4edd-a33e-5948104e7f49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ContractwithCustomerLiabilityIncreaseDecreasePercentage_192cc41f-a0c0-480a-9b42-bddc1b5f6077" xlink:href="endp-20210331.xsd#endp_ContractwithCustomerLiabilityIncreaseDecreasePercentage"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_endp_ContractwithCustomerLiabilityIncreaseDecreasePercentage_192cc41f-a0c0-480a-9b42-bddc1b5f6077" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_0836ce8c-2d82-492b-9387-47f8acc60134" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_0836ce8c-2d82-492b-9387-47f8acc60134" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e077f1db-14b0-4a2d-9899-f8dd36ebb83a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e077f1db-14b0-4a2d-9899-f8dd36ebb83a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ContractwithCustomerLiabilityIncreaseDecrease_18b00499-06e4-4585-9f4b-6040a80c1181" xlink:href="endp-20210331.xsd#endp_ContractwithCustomerLiabilityIncreaseDecrease"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_6a8ec8a6-0c95-47fa-9f25-f541af8f2836" xlink:to="loc_endp_ContractwithCustomerLiabilityIncreaseDecrease_18b00499-06e4-4585-9f4b-6040a80c1181" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ContractAssetsandLiabilitiesNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#ContractAssetsandLiabilitiesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/ContractAssetsandLiabilitiesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_10f0c577-8144-492a-9fe2-a03fd265230e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ContractWithCustomerPerformanceObligationSatisfactionPeriod_f037ecfc-44f5-48c0-9c28-bba31212abf6" xlink:href="endp-20210331.xsd#endp_ContractWithCustomerPerformanceObligationSatisfactionPeriod"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_10f0c577-8144-492a-9fe2-a03fd265230e" xlink:to="loc_endp_ContractWithCustomerPerformanceObligationSatisfactionPeriod_f037ecfc-44f5-48c0-9c28-bba31212abf6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerPerformanceObligationSatisfiedInPreviousPeriod_550f717d-367e-4f8d-8809-d51a28ba7cb6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerPerformanceObligationSatisfiedInPreviousPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerAssetAndLiabilityAbstract_10f0c577-8144-492a-9fe2-a03fd265230e" xlink:to="loc_us-gaap_ContractWithCustomerPerformanceObligationSatisfiedInPreviousPeriod_550f717d-367e-4f8d-8809-d51a28ba7cb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/AccountsPayableandAccruedExpenses" xlink:type="simple" xlink:href="endp-20210331.xsd#AccountsPayableandAccruedExpenses"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/AccountsPayableandAccruedExpenses" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_10ab401a-5f9f-4547-ac64-e3c5846d6401" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock_4774d5fb-9917-4b1a-9390-a00703b37edb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_10ab401a-5f9f-4547-ac64-e3c5846d6401" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock_4774d5fb-9917-4b1a-9390-a00703b37edb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/AccountsPayableandAccruedExpensesTables" xlink:type="simple" xlink:href="endp-20210331.xsd#AccountsPayableandAccruedExpensesTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/AccountsPayableandAccruedExpensesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_a178decb-a68d-43af-9ec1-f7af62e751bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_915c7b3b-5871-4742-a110-5315414f8167" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_a178decb-a68d-43af-9ec1-f7af62e751bf" xlink:to="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_915c7b3b-5871-4742-a110-5315414f8167" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/AccountsPayableandAccruedExpensesDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#AccountsPayableandAccruedExpensesDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/AccountsPayableandAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_819ff6ca-014a-4fdb-80fa-2f944fb4cb23" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_819ff6ca-014a-4fdb-80fa-2f944fb4cb23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedLiabilitiesReturnsAndAllowances_252eb1ac-1bfe-45af-8c20-338d004bdcdd" xlink:href="endp-20210331.xsd#endp_AccruedLiabilitiesReturnsAndAllowances"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_endp_AccruedLiabilitiesReturnsAndAllowances_252eb1ac-1bfe-45af-8c20-338d004bdcdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedLiabilitiesRebates_d8e510a4-3525-4015-9573-a4f3c3af7cae" xlink:href="endp-20210331.xsd#endp_AccruedLiabilitiesRebates"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_endp_AccruedLiabilitiesRebates_d8e510a4-3525-4015-9573-a4f3c3af7cae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedLiabilitiesChargebacks_35e60573-1352-425c-b476-60d96a88f250" xlink:href="endp-20210331.xsd#endp_AccruedLiabilitiesChargebacks"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_endp_AccruedLiabilitiesChargebacks_35e60573-1352-425c-b476-60d96a88f250" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_8c8874b0-01d3-4818-a064-3e15f6e0f94b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestPayableCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_us-gaap_InterestPayableCurrent_8c8874b0-01d3-4818-a064-3e15f6e0f94b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_a652128a-c78b-4061-a851-e5e5ac8a0a73" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_us-gaap_AccruedEmployeeBenefitsCurrent_a652128a-c78b-4061-a851-e5e5ac8a0a73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent_d2d2b601-3415-4951-86e9-d601ea68d30b" xlink:href="endp-20210331.xsd#endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent_d2d2b601-3415-4951-86e9-d601ea68d30b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_08d9cce3-398b-47a5-9d7a-7e8df3334ea8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_08d9cce3-398b-47a5-9d7a-7e8df3334ea8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_f12c694d-7663-4c6b-adce-95862b54717c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_f12c694d-7663-4c6b-adce-95862b54717c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_68d863d9-2dc6-4fdf-b50b-5e78db02f13d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_2665623d-e493-4116-8460-2ed6598d040e" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_68d863d9-2dc6-4fdf-b50b-5e78db02f13d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/Debt" xlink:type="simple" xlink:href="endp-20210331.xsd#Debt"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/Debt" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_e7f61249-c1f5-488b-b043-9da8b0d78f9c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_239f63fc-008b-4c84-b766-d3f81e2b67ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e7f61249-c1f5-488b-b043-9da8b0d78f9c" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_239f63fc-008b-4c84-b766-d3f81e2b67ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DebtTables" xlink:type="simple" xlink:href="endp-20210331.xsd#DebtTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DebtTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_1c69614c-6ba5-4ae6-8421-5b2fa64a07a7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_360257de-6bc8-49bf-973e-55e26289ad3e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_1c69614c-6ba5-4ae6-8421-5b2fa64a07a7" xlink:to="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_360257de-6bc8-49bf-973e-55e26289ad3e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_4a564491-9b7b-4eb2-82bc-3979f20f3124" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_1c69614c-6ba5-4ae6-8421-5b2fa64a07a7" xlink:to="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_4a564491-9b7b-4eb2-82bc-3979f20f3124" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DebtComponentsofTotalIndebtednessDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#DebtComponentsofTotalIndebtednessDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DebtComponentsofTotalIndebtednessDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_6dc32fed-a5fe-416a-a675-41e159c72fbe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_79ea2cac-c21d-4daf-ab42-1c293f8b97e5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_6dc32fed-a5fe-416a-a675-41e159c72fbe" xlink:to="loc_us-gaap_DebtInstrumentTable_79ea2cac-c21d-4daf-ab42-1c293f8b97e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_4360265f-8820-44fc-913d-ceeeafc82df6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_79ea2cac-c21d-4daf-ab42-1c293f8b97e5" xlink:to="loc_us-gaap_DebtInstrumentAxis_4360265f-8820-44fc-913d-ceeeafc82df6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_4360265f-8820-44fc-913d-ceeeafc82df6" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember_aff6c152-996d-4c91-b32f-1a6a7fb3a6d8" xlink:href="endp-20210331.xsd#endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember_aff6c152-996d-4c91-b32f-1a6a7fb3a6d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember_aa90f7df-1749-4a45-9e44-0606ee98d0bd" xlink:href="endp-20210331.xsd#endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember_aa90f7df-1749-4a45-9e44-0606ee98d0bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FivePointThreeSevenFiveSeniorNotesDueOnTwoThousandTwentyThreeMember_df8a0dee-1d8f-4f12-aa8d-6893164d7905" xlink:href="endp-20210331.xsd#endp_FivePointThreeSevenFiveSeniorNotesDueOnTwoThousandTwentyThreeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_FivePointThreeSevenFiveSeniorNotesDueOnTwoThousandTwentyThreeMember_df8a0dee-1d8f-4f12-aa8d-6893164d7905" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember_bb53a03b-29d6-4cc9-a435-c8ae20578a63" xlink:href="endp-20210331.xsd#endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember_bb53a03b-29d6-4cc9-a435-c8ae20578a63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember_ee51c26b-38f4-48bf-b496-e73ee2d41ab1" xlink:href="endp-20210331.xsd#endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember_ee51c26b-38f4-48bf-b496-e73ee2d41ab1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SixPercentSeniorNotesDue2025Member_249cab2f-1805-455c-9471-87d13491c926" xlink:href="endp-20210331.xsd#endp_SixPercentSeniorNotesDue2025Member"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_SixPercentSeniorNotesDue2025Member_249cab2f-1805-455c-9471-87d13491c926" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember_e90963be-c945-409d-ba20-33e3165d3b22" xlink:href="endp-20210331.xsd#endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember_e90963be-c945-409d-ba20-33e3165d3b22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_NinePointFivePercentSeniorNotesDue2027Member_5f077ba0-8623-4c10-bb6d-6a594abb9c97" xlink:href="endp-20210331.xsd#endp_NinePointFivePercentSeniorNotesDue2027Member"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_NinePointFivePercentSeniorNotesDue2027Member_5f077ba0-8623-4c10-bb6d-6a594abb9c97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SixPercentSeniorNotesDue2028Member_086b166e-eade-46c9-bfe5-1ce3d6837049" xlink:href="endp-20210331.xsd#endp_SixPercentSeniorNotesDue2028Member"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_SixPercentSeniorNotesDue2028Member_086b166e-eade-46c9-bfe5-1ce3d6837049" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member_13160b6d-758e-4ae6-ae24-bb1fd523cd18" xlink:href="endp-20210331.xsd#endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member_13160b6d-758e-4ae6-ae24-bb1fd523cd18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_TermLoanFacilityMember_7964dfcc-2264-4a40-acc7-23bc7ab52d4d" xlink:href="endp-20210331.xsd#endp_TermLoanFacilityMember"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6f556db2-5cc5-4601-89d7-70e9a3370cd3" xlink:to="loc_endp_TermLoanFacilityMember_7964dfcc-2264-4a40-acc7-23bc7ab52d4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_253b3cee-7bd2-40d4-9c2c-596b6a2c6aee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_79ea2cac-c21d-4daf-ab42-1c293f8b97e5" xlink:to="loc_us-gaap_CreditFacilityAxis_253b3cee-7bd2-40d4-9c2c-596b6a2c6aee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_eb06b7df-1776-494f-92f6-45de2a2ef9f3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_253b3cee-7bd2-40d4-9c2c-596b6a2c6aee" xlink:to="loc_us-gaap_CreditFacilityDomain_eb06b7df-1776-494f-92f6-45de2a2ef9f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_4b4524a3-1cb8-428a-8711-a8194e80f8ea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_eb06b7df-1776-494f-92f6-45de2a2ef9f3" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_4b4524a3-1cb8-428a-8711-a8194e80f8ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_79ea2cac-c21d-4daf-ab42-1c293f8b97e5" xlink:to="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2d709ac7-433a-4999-bdbe-52a4b2954649" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2d709ac7-433a-4999-bdbe-52a4b2954649" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_ba525677-9de3-4b9e-9455-59bb05200852" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_ba525677-9de3-4b9e-9455-59bb05200852" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_a2da68ac-500e-49cf-8a12-87f5e7cb2c8d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_a2da68ac-500e-49cf-8a12-87f5e7cb2c8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_ae4599f0-c5c3-42ae-97d9-037615221a95" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:to="loc_us-gaap_LongTermDebt_ae4599f0-c5c3-42ae-97d9-037615221a95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_d440dd25-cd42-4aa4-a323-75ad671fe0fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:to="loc_us-gaap_LongTermDebtCurrent_d440dd25-cd42-4aa4-a323-75ad671fe0fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_DebtInstrumentFaceAmountExcludingCurrentMaturities_9be983c2-1bb8-46ae-ae19-490977ce878b" xlink:href="endp-20210331.xsd#endp_DebtInstrumentFaceAmountExcludingCurrentMaturities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:to="loc_endp_DebtInstrumentFaceAmountExcludingCurrentMaturities_9be983c2-1bb8-46ae-ae19-490977ce878b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_cce0f252-7f2e-4962-ab97-6270f2f18b55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_cce0f252-7f2e-4962-ab97-6270f2f18b55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_5d9fea67-0655-4a43-8381-5f0c90efd4ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5970c478-3dcf-4efb-b7f7-61a33fa2825f" xlink:to="loc_us-gaap_LongTermDebtFairValue_5d9fea67-0655-4a43-8381-5f0c90efd4ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DebtCreditFacilityNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#DebtCreditFacilityNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DebtCreditFacilityNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_7efa6fea-bd17-44b9-bf80-b9d5f62c6373" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LineOfCreditFacilityTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_7efa6fea-bd17-44b9-bf80-b9d5f62c6373" xlink:to="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_966f79d2-e691-466f-a010-024fb041a5b0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_966f79d2-e691-466f-a010-024fb041a5b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_8882a031-68bb-41a2-b26b-643bc365cf7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_966f79d2-e691-466f-a010-024fb041a5b0" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_8882a031-68bb-41a2-b26b-643bc365cf7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_b92e4736-6165-4b2a-ad06-5559723ce16f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_8882a031-68bb-41a2-b26b-643bc365cf7a" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_b92e4736-6165-4b2a-ad06-5559723ce16f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_bb84977f-2358-4171-ae45-c4a014fce6a9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuredDebtMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_8882a031-68bb-41a2-b26b-643bc365cf7a" xlink:to="loc_us-gaap_SecuredDebtMember_bb84977f-2358-4171-ae45-c4a014fce6a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_70a91515-3a60-4757-b8df-b62d9849700c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:to="loc_us-gaap_DebtInstrumentAxis_70a91515-3a60-4757-b8df-b62d9849700c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_fbcc7721-3136-49cf-bfc2-d870094e1604" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_70a91515-3a60-4757-b8df-b62d9849700c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_fbcc7721-3136-49cf-bfc2-d870094e1604" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_A2017CreditAgreementMember_7a5d15f9-6aa9-4ad6-b79b-65163754a6c0" xlink:href="endp-20210331.xsd#endp_A2017CreditAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_fbcc7721-3136-49cf-bfc2-d870094e1604" xlink:to="loc_endp_A2017CreditAgreementMember_7a5d15f9-6aa9-4ad6-b79b-65163754a6c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember_a8c09efa-70e1-4de1-9f44-f670d4490f34" xlink:href="endp-20210331.xsd#endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_fbcc7721-3136-49cf-bfc2-d870094e1604" xlink:to="loc_endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember_a8c09efa-70e1-4de1-9f44-f670d4490f34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember_bcbb05b7-e343-4460-b497-a12eb28dc556" xlink:href="endp-20210331.xsd#endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_fbcc7721-3136-49cf-bfc2-d870094e1604" xlink:to="loc_endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember_bcbb05b7-e343-4460-b497-a12eb28dc556" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember_4ef95780-4078-4957-8c28-44386c260306" xlink:href="endp-20210331.xsd#endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_fbcc7721-3136-49cf-bfc2-d870094e1604" xlink:to="loc_endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember_4ef95780-4078-4957-8c28-44386c260306" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_NinePointFivePercentSeniorNotesDue2027Member_ce7ea215-393b-429b-9d92-2b744ab8f9e3" xlink:href="endp-20210331.xsd#endp_NinePointFivePercentSeniorNotesDue2027Member"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_fbcc7721-3136-49cf-bfc2-d870094e1604" xlink:to="loc_endp_NinePointFivePercentSeniorNotesDue2027Member_ce7ea215-393b-429b-9d92-2b744ab8f9e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_086e66ba-eb99-4950-b654-ea5486350f3b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:to="loc_us-gaap_CreditFacilityAxis_086e66ba-eb99-4950-b654-ea5486350f3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_f135257a-48a9-4718-9aec-b4bebe7745d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_086e66ba-eb99-4950-b654-ea5486350f3b" xlink:to="loc_us-gaap_CreditFacilityDomain_f135257a-48a9-4718-9aec-b4bebe7745d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_19db639b-70aa-4118-8186-0f94184d1a3d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_f135257a-48a9-4718-9aec-b4bebe7745d5" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_19db639b-70aa-4118-8186-0f94184d1a3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_TermLoanFacilityMember_aebd7bea-f653-4b03-8d82-7f3d3c12c66f" xlink:href="endp-20210331.xsd#endp_TermLoanFacilityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_f135257a-48a9-4718-9aec-b4bebe7745d5" xlink:to="loc_endp_TermLoanFacilityMember_aebd7bea-f653-4b03-8d82-7f3d3c12c66f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_cec2ca1c-5b34-4499-b7f1-7ba5645620cb" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:to="loc_srt_RangeAxis_cec2ca1c-5b34-4499-b7f1-7ba5645620cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_8bf06824-91c5-458c-919d-f1cdad0e8508" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_cec2ca1c-5b34-4499-b7f1-7ba5645620cb" xlink:to="loc_srt_RangeMember_8bf06824-91c5-458c-919d-f1cdad0e8508" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_92075252-282d-4729-b6a6-94505998d0d6" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_8bf06824-91c5-458c-919d-f1cdad0e8508" xlink:to="loc_srt_MinimumMember_92075252-282d-4729-b6a6-94505998d0d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_756a454d-980a-4b78-823d-6a519023f353" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_8bf06824-91c5-458c-919d-f1cdad0e8508" xlink:to="loc_srt_MaximumMember_756a454d-980a-4b78-823d-6a519023f353" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_d16f896e-1ae0-49ed-995f-88f72e0f86f8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:to="loc_us-gaap_VariableRateAxis_d16f896e-1ae0-49ed-995f-88f72e0f86f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_9d97b277-6caa-46a4-ade3-f14eebb45437" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_d16f896e-1ae0-49ed-995f-88f72e0f86f8" xlink:to="loc_us-gaap_VariableRateDomain_9d97b277-6caa-46a4-ade3-f14eebb45437" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_a0421ef1-402f-4fae-8065-5084ee75628b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_9d97b277-6caa-46a4-ade3-f14eebb45437" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_a0421ef1-402f-4fae-8065-5084ee75628b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BaseRateMember_f1660eb0-0f06-4fb4-be22-56e4dd72811f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BaseRateMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_9d97b277-6caa-46a4-ade3-f14eebb45437" xlink:to="loc_us-gaap_BaseRateMember_f1660eb0-0f06-4fb4-be22-56e4dd72811f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_32de4a15-099b-4440-80e6-330bc5d578d8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_32de4a15-099b-4440-80e6-330bc5d578d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_8234828c-bf9c-4986-8a7d-0100a9c3df83" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_32de4a15-099b-4440-80e6-330bc5d578d8" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_8234828c-bf9c-4986-8a7d-0100a9c3df83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_42493292-a335-4a70-a76e-37cbafd1112a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_8234828c-bf9c-4986-8a7d-0100a9c3df83" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_42493292-a335-4a70-a76e-37cbafd1112a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_6feabf46-2ecd-402e-b642-4221bf94b730" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_8234828c-bf9c-4986-8a7d-0100a9c3df83" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_6feabf46-2ecd-402e-b642-4221bf94b730" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_9fe9884a-0be7-4e0d-a5b9-b3266a2a1a2a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodThreeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_8234828c-bf9c-4986-8a7d-0100a9c3df83" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_9fe9884a-0be7-4e0d-a5b9-b3266a2a1a2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LineOfCreditFacilityLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_22bc34b6-507e-492e-9a94-17b0268899f1" xlink:to="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_c290fa40-42ff-49b5-bb40-fb4ea9e699f3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_c290fa40-42ff-49b5-bb40-fb4ea9e699f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_ffd9c385-2532-4f2d-943e-28821108b950" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_ffd9c385-2532-4f2d-943e-28821108b950" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_569714d6-3944-4eb5-b8be-549793259e52" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_569714d6-3944-4eb5-b8be-549793259e52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_3490a137-bd2d-4198-98d8-11d464d93fe1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_3490a137-bd2d-4198-98d8-11d464d93fe1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_DebtInstrumentQuarterlyPeriodicPaymentPercent_bfa69cc6-7a50-40d9-bec3-204259dceca2" xlink:href="endp-20210331.xsd#endp_DebtInstrumentQuarterlyPeriodicPaymentPercent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:to="loc_endp_DebtInstrumentQuarterlyPeriodicPaymentPercent_bfa69cc6-7a50-40d9-bec3-204259dceca2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_DebtInstrumentMaturityAccelerationAmountOutstandingThreshold_cfd07081-1db8-436b-918b-64485a9124e2" xlink:href="endp-20210331.xsd#endp_DebtInstrumentMaturityAccelerationAmountOutstandingThreshold"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:to="loc_endp_DebtInstrumentMaturityAccelerationAmountOutstandingThreshold_cfd07081-1db8-436b-918b-64485a9124e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_a76aea8a-098d-4630-b991-d8db2b6fe7fb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_a76aea8a-098d-4630-b991-d8db2b6fe7fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_DebtInstrumentBasisSpreadOnVariableRateFloor_60cffbcc-2a36-41f3-8ccc-5a862586cfe6" xlink:href="endp-20210331.xsd#endp_DebtInstrumentBasisSpreadOnVariableRateFloor"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_c051a3f4-fc79-4b75-9011-56825f842114" xlink:to="loc_endp_DebtInstrumentBasisSpreadOnVariableRateFloor_60cffbcc-2a36-41f3-8ccc-5a862586cfe6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DebtSeniorNotesandSeniorSecuredNotesDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#DebtSeniorNotesandSeniorSecuredNotesDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DebtSeniorNotesandSeniorSecuredNotesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_bc4b629e-6c37-4455-a0d5-f48d16b54303" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionTable_10de8cf1-e187-4f0c-84ff-45fd02d03ca2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_bc4b629e-6c37-4455-a0d5-f48d16b54303" xlink:to="loc_us-gaap_DebtInstrumentRedemptionTable_10de8cf1-e187-4f0c-84ff-45fd02d03ca2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_011edaf2-0f69-40dd-a802-931df5ca2d3a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionTable_10de8cf1-e187-4f0c-84ff-45fd02d03ca2" xlink:to="loc_us-gaap_DebtInstrumentAxis_011edaf2-0f69-40dd-a802-931df5ca2d3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_142aee9e-b731-4f7b-a681-fde66549d908" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_011edaf2-0f69-40dd-a802-931df5ca2d3a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_142aee9e-b731-4f7b-a681-fde66549d908" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember_f4e173e6-7a31-4e3c-9e12-14f3ff4bba84" xlink:href="endp-20210331.xsd#endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_142aee9e-b731-4f7b-a681-fde66549d908" xlink:to="loc_endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember_f4e173e6-7a31-4e3c-9e12-14f3ff4bba84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_NinePointFivePercentSeniorNotesDue2027Member_0e6733ee-aecc-488e-bbc9-029b1733e63d" xlink:href="endp-20210331.xsd#endp_NinePointFivePercentSeniorNotesDue2027Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_142aee9e-b731-4f7b-a681-fde66549d908" xlink:to="loc_endp_NinePointFivePercentSeniorNotesDue2027Member_0e6733ee-aecc-488e-bbc9-029b1733e63d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SixPercentSeniorNotesDue2028Member_578d6ea7-d4bf-4f0b-a6ea-31ce1fb89b58" xlink:href="endp-20210331.xsd#endp_SixPercentSeniorNotesDue2028Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_142aee9e-b731-4f7b-a681-fde66549d908" xlink:to="loc_endp_SixPercentSeniorNotesDue2028Member_578d6ea7-d4bf-4f0b-a6ea-31ce1fb89b58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member_7381c9df-81e2-4dd9-af25-2c69bf46ec48" xlink:href="endp-20210331.xsd#endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_142aee9e-b731-4f7b-a681-fde66549d908" xlink:to="loc_endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member_7381c9df-81e2-4dd9-af25-2c69bf46ec48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_04e5c571-f3c3-41d2-803e-45e04ce1ffc7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionTable_10de8cf1-e187-4f0c-84ff-45fd02d03ca2" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_04e5c571-f3c3-41d2-803e-45e04ce1ffc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_17aa3ef8-7c48-4c3d-811d-5366181fee07" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_04e5c571-f3c3-41d2-803e-45e04ce1ffc7" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_17aa3ef8-7c48-4c3d-811d-5366181fee07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_85728142-a0b9-4817-89e3-7c40a848dea8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_17aa3ef8-7c48-4c3d-811d-5366181fee07" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_85728142-a0b9-4817-89e3-7c40a848dea8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_976e1f6e-057b-4953-b7aa-781aa2e10aef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_17aa3ef8-7c48-4c3d-811d-5366181fee07" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_976e1f6e-057b-4953-b7aa-781aa2e10aef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_7f422153-081d-494b-877e-cc01a0eaf1fb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodThreeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_17aa3ef8-7c48-4c3d-811d-5366181fee07" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodThreeMember_7f422153-081d-494b-877e-cc01a0eaf1fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_85634426-a474-4875-a8b4-5bfb817d2e9c" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionTable_10de8cf1-e187-4f0c-84ff-45fd02d03ca2" xlink:to="loc_srt_RangeAxis_85634426-a474-4875-a8b4-5bfb817d2e9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_3ca23382-a173-4ba0-8de7-dc4cf5350367" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_85634426-a474-4875-a8b4-5bfb817d2e9c" xlink:to="loc_srt_RangeMember_3ca23382-a173-4ba0-8de7-dc4cf5350367" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_22e4be02-7985-4ce9-aa9a-24aa4a90b805" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_3ca23382-a173-4ba0-8de7-dc4cf5350367" xlink:to="loc_srt_MinimumMember_22e4be02-7985-4ce9-aa9a-24aa4a90b805" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_624b9158-56b7-4f74-8e2d-f4a9b62a9571" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_3ca23382-a173-4ba0-8de7-dc4cf5350367" xlink:to="loc_srt_MaximumMember_624b9158-56b7-4f74-8e2d-f4a9b62a9571" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionLineItems_7d859eb1-5038-4db8-a231-dd24c0876ee0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionTable_10de8cf1-e187-4f0c-84ff-45fd02d03ca2" xlink:to="loc_us-gaap_DebtInstrumentRedemptionLineItems_7d859eb1-5038-4db8-a231-dd24c0876ee0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_23ad71a4-1ecd-411f-af32-b089fd2267db" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionLineItems_7d859eb1-5038-4db8-a231-dd24c0876ee0" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_23ad71a4-1ecd-411f-af32-b089fd2267db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_bc72413f-d58e-41a4-8370-9544d9b37cdc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionLineItems_7d859eb1-5038-4db8-a231-dd24c0876ee0" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_bc72413f-d58e-41a4-8370-9544d9b37cdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DebtDebtRefinancingTransactionsNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#DebtDebtRefinancingTransactionsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DebtDebtRefinancingTransactionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_f37e072d-8b20-40a1-9ec9-33a1a7a03a8b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_b77ca9de-98e7-4e15-9843-9a59a7c389a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_f37e072d-8b20-40a1-9ec9-33a1a7a03a8b" xlink:to="loc_us-gaap_DebtInstrumentTable_b77ca9de-98e7-4e15-9843-9a59a7c389a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_3d664688-70d7-47a5-aaaf-58e0abffef30" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_b77ca9de-98e7-4e15-9843-9a59a7c389a6" xlink:to="loc_us-gaap_CreditFacilityAxis_3d664688-70d7-47a5-aaaf-58e0abffef30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_63c71633-a715-48e4-8d3a-a8e646991c12" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_3d664688-70d7-47a5-aaaf-58e0abffef30" xlink:to="loc_us-gaap_CreditFacilityDomain_63c71633-a715-48e4-8d3a-a8e646991c12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_9c50b118-a807-4acc-8b08-ce468b24d4be" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_63c71633-a715-48e4-8d3a-a8e646991c12" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_9c50b118-a807-4acc-8b08-ce468b24d4be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_2f6d1f9b-5055-4e78-9597-ad31445aa86f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_b77ca9de-98e7-4e15-9843-9a59a7c389a6" xlink:to="loc_us-gaap_DebtInstrumentAxis_2f6d1f9b-5055-4e78-9597-ad31445aa86f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_e5b218dd-d4eb-438b-a80b-1b2d37be5d20" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_2f6d1f9b-5055-4e78-9597-ad31445aa86f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_e5b218dd-d4eb-438b-a80b-1b2d37be5d20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember_ce78fa6f-6835-4750-bd1d-0b0fdf2eb5ec" xlink:href="endp-20210331.xsd#endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e5b218dd-d4eb-438b-a80b-1b2d37be5d20" xlink:to="loc_endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember_ce78fa6f-6835-4750-bd1d-0b0fdf2eb5ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_TermLoanFacilityMember_685a2fb6-2095-46c5-94c2-76accfeaf868" xlink:href="endp-20210331.xsd#endp_TermLoanFacilityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e5b218dd-d4eb-438b-a80b-1b2d37be5d20" xlink:to="loc_endp_TermLoanFacilityMember_685a2fb6-2095-46c5-94c2-76accfeaf868" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member_beae5fab-3c7c-42d0-a194-5f4d317aab5e" xlink:href="endp-20210331.xsd#endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e5b218dd-d4eb-438b-a80b-1b2d37be5d20" xlink:to="loc_endp_SixPointOneTwoFivePercentSeniorNotesDue2029Member_beae5fab-3c7c-42d0-a194-5f4d317aab5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_eb5ace96-4a9b-4567-ba37-30fc2c4deb63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_b77ca9de-98e7-4e15-9843-9a59a7c389a6" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_eb5ace96-4a9b-4567-ba37-30fc2c4deb63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_d62f499e-83c4-45b4-bcff-f05487d95bad" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_eb5ace96-4a9b-4567-ba37-30fc2c4deb63" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_d62f499e-83c4-45b4-bcff-f05487d95bad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_d2ba5a1b-2d49-44bf-97da-58646d269327" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_d62f499e-83c4-45b4-bcff-f05487d95bad" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_d2ba5a1b-2d49-44bf-97da-58646d269327" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_b77ca9de-98e7-4e15-9843-9a59a7c389a6" xlink:to="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSeniorDebt_2eb7b632-9a5e-4f7e-8425-b018c8bae066" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfSeniorDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_RepaymentsOfSeniorDebt_2eb7b632-9a5e-4f7e-8425-b018c8bae066" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WriteOffOfDeferredDebtIssuanceCost_977bfdff-8929-4074-861e-770a20a11a68" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WriteOffOfDeferredDebtIssuanceCost"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_WriteOffOfDeferredDebtIssuanceCost_977bfdff-8929-4074-861e-770a20a11a68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_63035ef5-1a4f-4314-8fa7-77b08a8f29c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_63035ef5-1a4f-4314-8fa7-77b08a8f29c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_eb85a721-ad53-4f1e-b8c8-f3432a821516" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_eb85a721-ad53-4f1e-b8c8-f3432a821516" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_5fb2dc02-0bec-4041-b959-2dcee521952e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_5fb2dc02-0bec-4041-b959-2dcee521952e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_61f7d5ce-11db-4fe8-87b4-1c07a173f892" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_61f7d5ce-11db-4fe8-87b4-1c07a173f892" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_DebtInstrumentExtendedMaturityModificationAmount_d26ab577-c8b3-4550-9abe-823b72c011cd" xlink:href="endp-20210331.xsd#endp_DebtInstrumentExtendedMaturityModificationAmount"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_endp_DebtInstrumentExtendedMaturityModificationAmount_d26ab577-c8b3-4550-9abe-823b72c011cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAmount_d364d81d-899a-4e52-b226-e17dd058896b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ExtinguishmentOfDebtAmount"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAmount_d364d81d-899a-4e52-b226-e17dd058896b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ffeac662-bb3f-407b-8925-5fdb8fc91196" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ffeac662-bb3f-407b-8925-5fdb8fc91196" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_f949725f-ba0d-4f74-87c8-9c52c2b0b421" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFinanceCostsGross"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_429ddacd-5254-44be-8f12-0bd6ddd675bd" xlink:to="loc_us-gaap_DeferredFinanceCostsGross_f949725f-ba0d-4f74-87c8-9c52c2b0b421" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/DebtMaturitiesofLongTermDebtDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#DebtMaturitiesofLongTermDebtDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/DebtMaturitiesofLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_6c664219-f417-44a3-a6b9-ece30e91b506" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_5e697773-528c-4e31-ab7d-a7d351a93980" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_6c664219-f417-44a3-a6b9-ece30e91b506" xlink:to="loc_us-gaap_DebtInstrumentTable_5e697773-528c-4e31-ab7d-a7d351a93980" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_74b979e3-5b4a-45d7-abed-8ea53ce24e46" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_5e697773-528c-4e31-ab7d-a7d351a93980" xlink:to="loc_us-gaap_CreditFacilityAxis_74b979e3-5b4a-45d7-abed-8ea53ce24e46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_f801d3a3-669c-47cd-b48e-2192b091d203" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_74b979e3-5b4a-45d7-abed-8ea53ce24e46" xlink:to="loc_us-gaap_CreditFacilityDomain_f801d3a3-669c-47cd-b48e-2192b091d203" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_e4498fe3-dcd2-470d-9923-5e818f636346" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_f801d3a3-669c-47cd-b48e-2192b091d203" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_e4498fe3-dcd2-470d-9923-5e818f636346" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_889543c4-5fcb-43eb-93ac-03dd7ba61234" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_5e697773-528c-4e31-ab7d-a7d351a93980" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_889543c4-5fcb-43eb-93ac-03dd7ba61234" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_f09c69f1-1d6f-4bec-81c9-a0108bee9d43" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_889543c4-5fcb-43eb-93ac-03dd7ba61234" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_f09c69f1-1d6f-4bec-81c9-a0108bee9d43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_7f6b645a-b3d8-4e41-b54b-8c0bd6332765" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_f09c69f1-1d6f-4bec-81c9-a0108bee9d43" xlink:to="loc_us-gaap_SeniorNotesMember_7f6b645a-b3d8-4e41-b54b-8c0bd6332765" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_d2262bcf-7828-4ad5-9233-acbd9e214892" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_5e697773-528c-4e31-ab7d-a7d351a93980" xlink:to="loc_us-gaap_DebtInstrumentAxis_d2262bcf-7828-4ad5-9233-acbd9e214892" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_e9d893a1-816c-4c72-84b1-7bead67a6c3c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_d2262bcf-7828-4ad5-9233-acbd9e214892" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_e9d893a1-816c-4c72-84b1-7bead67a6c3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SeniorNotesMaturingDue2022Member_59a26ba1-6b91-4b0b-89c0-8704f4ba8f89" xlink:href="endp-20210331.xsd#endp_SeniorNotesMaturingDue2022Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e9d893a1-816c-4c72-84b1-7bead67a6c3c" xlink:to="loc_endp_SeniorNotesMaturingDue2022Member_59a26ba1-6b91-4b0b-89c0-8704f4ba8f89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_94c7ac1a-b05c-4dd7-a5e6-a888d0a9e087" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_5e697773-528c-4e31-ab7d-a7d351a93980" xlink:to="loc_us-gaap_DebtInstrumentLineItems_94c7ac1a-b05c-4dd7-a5e6-a888d0a9e087" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtByMaturityAbstract_7773a7ca-afc2-413f-83c2-ae6baf1839a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtByMaturityAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94c7ac1a-b05c-4dd7-a5e6-a888d0a9e087" xlink:to="loc_us-gaap_LongTermDebtByMaturityAbstract_7773a7ca-afc2-413f-83c2-ae6baf1839a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_4ff36ac5-51d3-4794-9f80-64d598b85bc0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_7773a7ca-afc2-413f-83c2-ae6baf1839a2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_4ff36ac5-51d3-4794-9f80-64d598b85bc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_59dfbd37-9827-4183-9482-28d4a0697b97" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_7773a7ca-afc2-413f-83c2-ae6baf1839a2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_59dfbd37-9827-4183-9482-28d4a0697b97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_55027410-a1b0-4347-ab06-ad1b81500401" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_7773a7ca-afc2-413f-83c2-ae6baf1839a2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_55027410-a1b0-4347-ab06-ad1b81500401" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_a4702d9a-d553-4777-b442-818e4f0e1725" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_7773a7ca-afc2-413f-83c2-ae6baf1839a2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_a4702d9a-d553-4777-b442-818e4f0e1725" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_146aac60-8fc1-4bac-91d6-7daf02b8efa5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_7773a7ca-afc2-413f-83c2-ae6baf1839a2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_146aac60-8fc1-4bac-91d6-7daf02b8efa5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LongtermDebtMaturityRepaymentDeadline_8cba20ec-c0cf-4b87-9913-a83d67099927" xlink:href="endp-20210331.xsd#endp_LongtermDebtMaturityRepaymentDeadline"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94c7ac1a-b05c-4dd7-a5e6-a888d0a9e087" xlink:to="loc_endp_LongtermDebtMaturityRepaymentDeadline_8cba20ec-c0cf-4b87-9913-a83d67099927" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="endp-20210331.xsd#CommitmentsandContingencies"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CommitmentsandContingencies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_e1e1f426-7d5a-46f2-992c-713064bafe27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_387e0ed5-bf3f-4324-84af-e43721ed87d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_e1e1f426-7d5a-46f2-992c-713064bafe27" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_387e0ed5-bf3f-4324-84af-e43721ed87d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CommitmentsandContingenciesTables" xlink:type="simple" xlink:href="endp-20210331.xsd#CommitmentsandContingenciesTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CommitmentsandContingenciesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_141880ca-8065-4265-8fa1-2103752c4f25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfLossContingenciesByContingencyTextBlock_def5d8db-48c5-4c6d-9c27-ae70d130c605" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfLossContingenciesByContingencyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_141880ca-8065-4265-8fa1-2103752c4f25" xlink:to="loc_us-gaap_ScheduleOfLossContingenciesByContingencyTextBlock_def5d8db-48c5-4c6d-9c27-ae70d130c605" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_f053add0-ca99-4152-8838-4fa71f40115e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_e986e01c-3644-40a7-9f55-a03176e50335" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_f053add0-ca99-4152-8838-4fa71f40115e" xlink:to="loc_us-gaap_LossContingenciesTable_e986e01c-3644-40a7-9f55-a03176e50335" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_e2312e32-7100-4e84-894a-b5a5a73e7d4c" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_e986e01c-3644-40a7-9f55-a03176e50335" xlink:to="loc_srt_ProductOrServiceAxis_e2312e32-7100-4e84-894a-b5a5a73e7d4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_ff31caf0-b600-46c1-93be-8af79351073b" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_e2312e32-7100-4e84-894a-b5a5a73e7d4c" xlink:to="loc_srt_ProductsAndServicesDomain_ff31caf0-b600-46c1-93be-8af79351073b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_VASOSTRICTandorADRENALINMember_50670411-af8c-41fd-bbbd-dbf26123333d" xlink:href="endp-20210331.xsd#endp_VASOSTRICTandorADRENALINMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_ff31caf0-b600-46c1-93be-8af79351073b" xlink:to="loc_endp_VASOSTRICTandorADRENALINMember_50670411-af8c-41fd-bbbd-dbf26123333d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_1eb37344-690f-4f0e-a1d7-0f4aa0e2b96a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_e986e01c-3644-40a7-9f55-a03176e50335" xlink:to="loc_dei_LegalEntityAxis_1eb37344-690f-4f0e-a1d7-0f4aa0e2b96a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_ccb0936e-68af-42f9-8982-50b36e421006" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_1eb37344-690f-4f0e-a1d7-0f4aa0e2b96a" xlink:to="loc_dei_EntityDomain_ccb0936e-68af-42f9-8982-50b36e421006" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_AmericanMedicalSystemsMember_bb9af0b2-2184-4cdb-9248-6272fe3f9f64" xlink:href="endp-20210331.xsd#endp_AmericanMedicalSystemsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_ccb0936e-68af-42f9-8982-50b36e421006" xlink:to="loc_endp_AmericanMedicalSystemsMember_bb9af0b2-2184-4cdb-9248-6272fe3f9f64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_PSPLLCMember_58d82ed8-fd6e-40a2-b0ee-d950813911f7" xlink:href="endp-20210331.xsd#endp_PSPLLCMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_ccb0936e-68af-42f9-8982-50b36e421006" xlink:to="loc_endp_PSPLLCMember_58d82ed8-fd6e-40a2-b0ee-d950813911f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ParPharmaceuticalInc.Member_78b7398d-728d-40ad-b6d8-6edb04697e7f" xlink:href="endp-20210331.xsd#endp_ParPharmaceuticalInc.Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_ccb0936e-68af-42f9-8982-50b36e421006" xlink:to="loc_endp_ParPharmaceuticalInc.Member_78b7398d-728d-40ad-b6d8-6edb04697e7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_3940b573-41c8-4f0f-befc-31fe94808362" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_e986e01c-3644-40a7-9f55-a03176e50335" xlink:to="loc_srt_LitigationCaseAxis_3940b573-41c8-4f0f-befc-31fe94808362" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_83803625-30c1-4c3d-8461-56f9f6e0deb3" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseAxis_3940b573-41c8-4f0f-befc-31fe94808362" xlink:to="loc_srt_LitigationCaseTypeDomain_83803625-30c1-4c3d-8461-56f9f6e0deb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_VaginalMeshCasesMember_23293fc7-6381-47fd-816d-3b9cd13d4870" xlink:href="endp-20210331.xsd#endp_VaginalMeshCasesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_83803625-30c1-4c3d-8461-56f9f6e0deb3" xlink:to="loc_endp_VaginalMeshCasesMember_23293fc7-6381-47fd-816d-3b9cd13d4870" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_OpioidRelatedMattersMember_e6761340-8cda-45b4-a8cb-16e4fe3bbe71" xlink:href="endp-20210331.xsd#endp_OpioidRelatedMattersMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_83803625-30c1-4c3d-8461-56f9f6e0deb3" xlink:to="loc_endp_OpioidRelatedMattersMember_e6761340-8cda-45b4-a8cb-16e4fe3bbe71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_PublicEmployeesRetirementSystemofMississippivs.EndoInternationalPLCMember_11a6e269-df5a-4b06-837f-becbed1d2c23" xlink:href="endp-20210331.xsd#endp_PublicEmployeesRetirementSystemofMississippivs.EndoInternationalPLCMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_83803625-30c1-4c3d-8461-56f9f6e0deb3" xlink:to="loc_endp_PublicEmployeesRetirementSystemofMississippivs.EndoInternationalPLCMember_11a6e269-df5a-4b06-837f-becbed1d2c23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_VASOSTRICTRelatedMattersMember_2a15a960-23ff-4394-a99c-4cd712e29fb5" xlink:href="endp-20210331.xsd#endp_VASOSTRICTRelatedMattersMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_83803625-30c1-4c3d-8461-56f9f6e0deb3" xlink:to="loc_endp_VASOSTRICTRelatedMattersMember_2a15a960-23ff-4394-a99c-4cd712e29fb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_693a5ae7-22c2-4804-bfaf-872ca5a4f67a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_e986e01c-3644-40a7-9f55-a03176e50335" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_693a5ae7-22c2-4804-bfaf-872ca5a4f67a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_30fd3c2a-8cbd-4dac-97c9-434c58286c46" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_693a5ae7-22c2-4804-bfaf-872ca5a4f67a" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_30fd3c2a-8cbd-4dac-97c9-434c58286c46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_9a6a51bc-b806-4161-822a-14040ed988f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_30fd3c2a-8cbd-4dac-97c9-434c58286c46" xlink:to="loc_us-gaap_SubsequentEventMember_9a6a51bc-b806-4161-822a-14040ed988f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_e986e01c-3644-40a7-9f55-a03176e50335" xlink:to="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_e4c26edb-d6d0-4d52-af72-b8f5f52f8fa8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_e4c26edb-d6d0-4d52-af72-b8f5f52f8fa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyClaimsSettledNumber_9dd36275-a3e1-41b3-8fa3-d39f0e4ea9a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyClaimsSettledNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_us-gaap_LossContingencyClaimsSettledNumber_9dd36275-a3e1-41b3-8fa3-d39f0e4ea9a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualPayments_8c491b0b-d120-4a47-94ea-92d2db40e979" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyAccrualPayments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_us-gaap_LossContingencyAccrualPayments_8c491b0b-d120-4a47-94ea-92d2db40e979" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFunds_c4d62604-acea-42cd-aae9-dffcd90fc6df" xlink:href="endp-20210331.xsd#endp_SettlementFunds"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_SettlementFunds_c4d62604-acea-42cd-aae9-dffcd90fc6df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyClaimsFiledByStatesNumber_5cdf216b-b0cf-4ec7-bb11-3e0888396e57" xlink:href="endp-20210331.xsd#endp_LossContingencyClaimsFiledByStatesNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyClaimsFiledByStatesNumber_5cdf216b-b0cf-4ec7-bb11-3e0888396e57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyPendingClaimsNumber_cedef8e5-ab9e-43b0-8a78-622106c67698" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyPendingClaimsNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_us-gaap_LossContingencyPendingClaimsNumber_cedef8e5-ab9e-43b0-8a78-622106c67698" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty_7af38d5b-196f-4879-83a0-b85965364e13" xlink:href="endp-20210331.xsd#endp_LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty_7af38d5b-196f-4879-83a0-b85965364e13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath_ac38a742-0cb2-464e-aaea-66b35cd5861c" xlink:href="endp-20210331.xsd#endp_LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath_ac38a742-0cb2-464e-aaea-66b35cd5861c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyNumberOfPutativeClassActions_365feeda-bae4-4966-af88-e137655b6a56" xlink:href="endp-20210331.xsd#endp_LossContingencyNumberOfPutativeClassActions"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyNumberOfPutativeClassActions_365feeda-bae4-4966-af88-e137655b6a56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyPlaintiffsNumberOfCounties_df95966a-7c0d-4baf-ad57-f2ee5baa50a4" xlink:href="endp-20210331.xsd#endp_LossContingencyPlaintiffsNumberOfCounties"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyPlaintiffsNumberOfCounties_df95966a-7c0d-4baf-ad57-f2ee5baa50a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementAmountAwardedToOtherParty_342a91e8-430e-40c9-91c3-80269fdfd0dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LitigationSettlementAmountAwardedToOtherParty"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_us-gaap_LitigationSettlementAmountAwardedToOtherParty_342a91e8-430e-40c9-91c3-80269fdfd0dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesSoughtValue_212fa357-6ba6-4da8-a37a-981ef4ad7396" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyDamagesSoughtValue"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_us-gaap_LossContingencyDamagesSoughtValue_212fa357-6ba6-4da8-a37a-981ef4ad7396" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyCountiesSubstitutedIntoTheCaseSetForTrialNumber_7556c2ab-3734-4cee-82c7-a130cb6f16bd" xlink:href="endp-20210331.xsd#endp_LossContingencyCountiesSubstitutedIntoTheCaseSetForTrialNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyCountiesSubstitutedIntoTheCaseSetForTrialNumber_7556c2ab-3734-4cee-82c7-a130cb6f16bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyPeriodProvidedForAdditionalCountiesToJoinTheLawsuit_64a50406-5c33-4ad0-a38d-24532f6e1d09" xlink:href="endp-20210331.xsd#endp_LossContingencyPeriodProvidedForAdditionalCountiesToJoinTheLawsuit"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyPeriodProvidedForAdditionalCountiesToJoinTheLawsuit_64a50406-5c33-4ad0-a38d-24532f6e1d09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_NumberOfFormerEmployees_defa0166-72dc-4ca3-b5a5-5493437ede24" xlink:href="endp-20210331.xsd#endp_NumberOfFormerEmployees"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_NumberOfFormerEmployees_defa0166-72dc-4ca3-b5a5-5493437ede24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyLawsuitFilingPeriod_25ce3d8b-231b-4bb6-a65f-b2b6fe7e22b7" xlink:href="endp-20210331.xsd#endp_LossContingencyLawsuitFilingPeriod"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyLawsuitFilingPeriod_25ce3d8b-231b-4bb6-a65f-b2b6fe7e22b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyStayOfApprovalPeriodHatchWaxmanAct_ef8a19d4-8612-4ab1-bff2-2f0f55ee57c4" xlink:href="endp-20210331.xsd#endp_LossContingencyStayOfApprovalPeriodHatchWaxmanAct"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_d9a43820-be40-4714-adba-3439fd4e4771" xlink:to="loc_endp_LossContingencyStayOfApprovalPeriodHatchWaxmanAct_ef8a19d4-8612-4ab1-bff2-2f0f55ee57c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/CommitmentsandContingenciesScheduleofLossContingenciesDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#CommitmentsandContingenciesScheduleofLossContingenciesDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/CommitmentsandContingenciesScheduleofLossContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_341f38eb-2104-4060-b2b1-06872d04da4b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_17e1b10b-42f8-45b5-bbfe-5777cdcee5cc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_341f38eb-2104-4060-b2b1-06872d04da4b" xlink:to="loc_us-gaap_LossContingenciesTable_17e1b10b-42f8-45b5-bbfe-5777cdcee5cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_f13dd81e-c0aa-41f6-8842-3bea689a0e78" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_17e1b10b-42f8-45b5-bbfe-5777cdcee5cc" xlink:to="loc_srt_LitigationCaseAxis_f13dd81e-c0aa-41f6-8842-3bea689a0e78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_388c5b92-db2e-4c43-bcfa-38838f0a472e" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseAxis_f13dd81e-c0aa-41f6-8842-3bea689a0e78" xlink:to="loc_srt_LitigationCaseTypeDomain_388c5b92-db2e-4c43-bcfa-38838f0a472e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_VaginalMeshCasesMember_3d629c8b-fefa-49bf-846f-0f3ef0119d2b" xlink:href="endp-20210331.xsd#endp_VaginalMeshCasesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_388c5b92-db2e-4c43-bcfa-38838f0a472e" xlink:to="loc_endp_VaginalMeshCasesMember_3d629c8b-fefa-49bf-846f-0f3ef0119d2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_83343bba-cb49-4a32-b6f7-4730dd09aee4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_17e1b10b-42f8-45b5-bbfe-5777cdcee5cc" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_83343bba-cb49-4a32-b6f7-4730dd09aee4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_ea89178f-05cd-4734-a679-0a96ef71719e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_83343bba-cb49-4a32-b6f7-4730dd09aee4" xlink:to="loc_us-gaap_LossContingencyNatureDomain_ea89178f-05cd-4734-a679-0a96ef71719e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ProductLiabilityMember_1d7f8303-4ded-49d3-bcc7-dd98875b2ed3" xlink:href="endp-20210331.xsd#endp_ProductLiabilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyNatureDomain_ea89178f-05cd-4734-a679-0a96ef71719e" xlink:to="loc_endp_ProductLiabilityMember_1d7f8303-4ded-49d3-bcc7-dd98875b2ed3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_9edca12a-1f26-4824-9ac3-e7ce2f37b18a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_17e1b10b-42f8-45b5-bbfe-5777cdcee5cc" xlink:to="loc_us-gaap_LossContingenciesLineItems_9edca12a-1f26-4824-9ac3-e7ce2f37b18a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFundsRollForward_ba2cb5eb-9187-4194-80f2-68e71f08a493" xlink:href="endp-20210331.xsd#endp_SettlementFundsRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_9edca12a-1f26-4824-9ac3-e7ce2f37b18a" xlink:to="loc_endp_SettlementFundsRollForward_ba2cb5eb-9187-4194-80f2-68e71f08a493" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFunds_b82ca0a0-b829-4a60-9e9a-e847a7f16cfe" xlink:href="endp-20210331.xsd#endp_SettlementFunds"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SettlementFundsRollForward_ba2cb5eb-9187-4194-80f2-68e71f08a493" xlink:to="loc_endp_SettlementFunds_b82ca0a0-b829-4a60-9e9a-e847a7f16cfe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualProvision_64089ece-fbf1-4327-8a93-db93daa6d525" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyAccrualProvision"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SettlementFundsRollForward_ba2cb5eb-9187-4194-80f2-68e71f08a493" xlink:to="loc_us-gaap_LossContingencyAccrualProvision_64089ece-fbf1-4327-8a93-db93daa6d525" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFundsCashContributionsToQualifiedSettlementFunds_73c3ca59-56d1-42bf-8da3-9be1db45778c" xlink:href="endp-20210331.xsd#endp_SettlementFundsCashContributionsToQualifiedSettlementFunds"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SettlementFundsRollForward_ba2cb5eb-9187-4194-80f2-68e71f08a493" xlink:to="loc_endp_SettlementFundsCashContributionsToQualifiedSettlementFunds_73c3ca59-56d1-42bf-8da3-9be1db45778c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds_dfc8f3c8-34db-4270-9504-ea98c77881cc" xlink:href="endp-20210331.xsd#endp_SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SettlementFundsRollForward_ba2cb5eb-9187-4194-80f2-68e71f08a493" xlink:to="loc_endp_SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds_dfc8f3c8-34db-4270-9504-ea98c77881cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFundsOther_97526078-6575-4d20-9811-218fcca61729" xlink:href="endp-20210331.xsd#endp_SettlementFundsOther"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SettlementFundsRollForward_ba2cb5eb-9187-4194-80f2-68e71f08a493" xlink:to="loc_endp_SettlementFundsOther_97526078-6575-4d20-9811-218fcca61729" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFunds_7f30f2e9-778f-4995-95ca-eb2bde56014c" xlink:href="endp-20210331.xsd#endp_SettlementFunds"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_SettlementFundsRollForward_ba2cb5eb-9187-4194-80f2-68e71f08a493" xlink:to="loc_endp_SettlementFunds_7f30f2e9-778f-4995-95ca-eb2bde56014c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualRollForward_ed40a5c9-06a7-4fe9-90fb-8c63b3873a36" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyAccrualRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_9edca12a-1f26-4824-9ac3-e7ce2f37b18a" xlink:to="loc_us-gaap_LossContingencyAccrualRollForward_ed40a5c9-06a7-4fe9-90fb-8c63b3873a36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_c0b1d6a1-4a68-4294-a9db-7acec24bf11e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyAccrualRollForward_ed40a5c9-06a7-4fe9-90fb-8c63b3873a36" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_c0b1d6a1-4a68-4294-a9db-7acec24bf11e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds_027f0621-95ec-4aeb-981b-687ab37815c0" xlink:href="endp-20210331.xsd#endp_LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyAccrualRollForward_ed40a5c9-06a7-4fe9-90fb-8c63b3873a36" xlink:to="loc_endp_LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds_027f0621-95ec-4aeb-981b-687ab37815c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_LossContingencyAccrualPaymentsToPlaintiffCounsel_86604c19-fd0e-46cd-9135-29fb7c6256b6" xlink:href="endp-20210331.xsd#endp_LossContingencyAccrualPaymentsToPlaintiffCounsel"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyAccrualRollForward_ed40a5c9-06a7-4fe9-90fb-8c63b3873a36" xlink:to="loc_endp_LossContingencyAccrualPaymentsToPlaintiffCounsel_86604c19-fd0e-46cd-9135-29fb7c6256b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_SettlementFundsOther_46d38e2e-7698-4b70-b254-6272ed1af737" xlink:href="endp-20210331.xsd#endp_SettlementFundsOther"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyAccrualRollForward_ed40a5c9-06a7-4fe9-90fb-8c63b3873a36" xlink:to="loc_endp_SettlementFundsOther_46d38e2e-7698-4b70-b254-6272ed1af737" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_ddd22b12-83bf-46a9-8d45-6080581ad421" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyAccrualRollForward_ed40a5c9-06a7-4fe9-90fb-8c63b3873a36" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_ddd22b12-83bf-46a9-8d45-6080581ad421" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/OtherComprehensiveIncomeLoss" xlink:type="simple" xlink:href="endp-20210331.xsd#OtherComprehensiveIncomeLoss"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/OtherComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_53b8edad-afab-4676-9067-4bce9f6507e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_6d692126-ed3d-4534-aad0-b59e4e1a4888" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNoteTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_53b8edad-afab-4676-9067-4bce9f6507e6" xlink:to="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_6d692126-ed3d-4534-aad0-b59e4e1a4888" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/OtherComprehensiveIncomeLossNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#OtherComprehensiveIncomeLossNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/OtherComprehensiveIncomeLossNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_5c27beb3-dbf7-4ff5-bc9b-02818f810478" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_4e620160-eed1-44d0-8501-794d8ea686a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_5c27beb3-dbf7-4ff5-bc9b-02818f810478" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_4e620160-eed1-44d0-8501-794d8ea686a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_0249b780-bfea-4b39-83b5-9405cb99202c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_5c27beb3-dbf7-4ff5-bc9b-02818f810478" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_0249b780-bfea-4b39-83b5-9405cb99202c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ShareholdersDeficit" xlink:type="simple" xlink:href="endp-20210331.xsd#ShareholdersDeficit"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/ShareholdersDeficit" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_ea5350ba-c9f4-4512-a7cc-400d83788dcb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_fd5403f7-3feb-4aea-bbe1-6c05c971079c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_ea5350ba-c9f4-4512-a7cc-400d83788dcb" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_fd5403f7-3feb-4aea-bbe1-6c05c971079c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ShareholdersDeficitTables" xlink:type="simple" xlink:href="endp-20210331.xsd#ShareholdersDeficitTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/ShareholdersDeficitTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_71a2c23d-0590-4322-9b39-73ffb118e212" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockholdersEquityTableTextBlock_aa59db25-edaa-4961-aa3e-ab61ffaab58a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfStockholdersEquityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_71a2c23d-0590-4322-9b39-73ffb118e212" xlink:to="loc_us-gaap_ScheduleOfStockholdersEquityTableTextBlock_aa59db25-edaa-4961-aa3e-ab61ffaab58a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ShareholdersDeficitDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#ShareholdersDeficitDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/ShareholdersDeficitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_c2da482e-4331-4520-8326-ec691ead4508" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_ScheduleOfStockholdersEquityTable_e5bce31d-52cf-43b8-8ca4-f068a81f3758" xlink:href="endp-20210331.xsd#endp_ScheduleOfStockholdersEquityTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_c2da482e-4331-4520-8326-ec691ead4508" xlink:to="loc_endp_ScheduleOfStockholdersEquityTable_e5bce31d-52cf-43b8-8ca4-f068a81f3758" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_fcac505d-ca91-4016-946b-107feb336870" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_ScheduleOfStockholdersEquityTable_e5bce31d-52cf-43b8-8ca4-f068a81f3758" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_fcac505d-ca91-4016-946b-107feb336870" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_ba212968-e4a8-49eb-9eb4-4eae6952324b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_fcac505d-ca91-4016-946b-107feb336870" xlink:to="loc_us-gaap_EquityComponentDomain_ba212968-e4a8-49eb-9eb4-4eae6952324b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EuroDeferredSharesMember_3d631db8-db4b-4a61-9a2a-0d6aad45650a" xlink:href="endp-20210331.xsd#endp_EuroDeferredSharesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ba212968-e4a8-49eb-9eb4-4eae6952324b" xlink:to="loc_endp_EuroDeferredSharesMember_3d631db8-db4b-4a61-9a2a-0d6aad45650a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_2b9b8a42-0cb8-421b-bdef-83df957722a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ba212968-e4a8-49eb-9eb4-4eae6952324b" xlink:to="loc_us-gaap_CommonStockMember_2b9b8a42-0cb8-421b-bdef-83df957722a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_c92aaa55-f534-47fc-ad7c-9c8a6a893bf7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ba212968-e4a8-49eb-9eb4-4eae6952324b" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_c92aaa55-f534-47fc-ad7c-9c8a6a893bf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_c6bf319b-6b83-4f4e-900b-3194f7472cd0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ba212968-e4a8-49eb-9eb4-4eae6952324b" xlink:to="loc_us-gaap_RetainedEarningsMember_c6bf319b-6b83-4f4e-900b-3194f7472cd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f16866dd-d281-422f-b90d-a2a8871a88cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ba212968-e4a8-49eb-9eb4-4eae6952324b" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f16866dd-d281-422f-b90d-a2a8871a88cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_697ca77d-d450-46a9-bdb4-3c3a54847ea2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_endp_ScheduleOfStockholdersEquityTable_e5bce31d-52cf-43b8-8ca4-f068a81f3758" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_697ca77d-d450-46a9-bdb4-3c3a54847ea2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_697ca77d-d450-46a9-bdb4-3c3a54847ea2" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_5b5add64-e81e-4ae8-b852-3c09e4399071" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:to="loc_us-gaap_StockholdersEquity_5b5add64-e81e-4ae8-b852-3c09e4399071" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_05b00c48-aa79-4194-a161-c39f1d051e27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:to="loc_us-gaap_NetIncomeLoss_05b00c48-aa79-4194-a161-c39f1d051e27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_aee96dc5-552c-42c0-bf41-90b6583c2cce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_aee96dc5-552c-42c0-bf41-90b6583c2cce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_4006c068-fa50-43eb-844a-1511624af9a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_4006c068-fa50-43eb-844a-1511624af9a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_550f16ff-7d6e-4b30-b0e5-f920955cd00c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_550f16ff-7d6e-4b30-b0e5-f920955cd00c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_d6cf29f0-b2b7-49de-b83d-a0aa861543e9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_d6cf29f0-b2b7-49de-b83d-a0aa861543e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityOther_a73ae540-916a-4f35-aab8-63aa4b45d712" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquityOther"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:to="loc_us-gaap_StockholdersEquityOther_a73ae540-916a-4f35-aab8-63aa4b45d712" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f6d46e7d-ede3-4cad-8f09-61565545a2a7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1bab9ef3-fed7-46e8-a31e-ce2618d793b7" xlink:to="loc_us-gaap_StockholdersEquity_f6d46e7d-ede3-4cad-8f09-61565545a2a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/ShareholdersDeficitNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#ShareholdersDeficitNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/ShareholdersDeficitNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_28b5431b-e741-4efd-8100-4c1840af7fd3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_07ea1749-5fdb-49bf-8ae3-d15797acaaac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_28b5431b-e741-4efd-8100-4c1840af7fd3" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_07ea1749-5fdb-49bf-8ae3-d15797acaaac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_26170cc8-1038-4ec3-8472-527ec623bee5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_07ea1749-5fdb-49bf-8ae3-d15797acaaac" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_26170cc8-1038-4ec3-8472-527ec623bee5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_6058a6eb-31b7-49ac-8ac7-27d0f4258ea6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_26170cc8-1038-4ec3-8472-527ec623bee5" xlink:to="loc_us-gaap_EquityComponentDomain_6058a6eb-31b7-49ac-8ac7-27d0f4258ea6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_75be4052-1491-450e-bd78-62d1b3485a14" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6058a6eb-31b7-49ac-8ac7-27d0f4258ea6" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_75be4052-1491-450e-bd78-62d1b3485a14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_69ae130c-98bd-44f3-ac3b-bfdb1895d996" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_07ea1749-5fdb-49bf-8ae3-d15797acaaac" xlink:to="loc_us-gaap_AwardTypeAxis_69ae130c-98bd-44f3-ac3b-bfdb1895d996" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_760e1de4-3665-4774-aed5-ec291d66266f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_69ae130c-98bd-44f3-ac3b-bfdb1895d996" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_760e1de4-3665-4774-aed5-ec291d66266f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_NonVestedStockOptionsMember_47eaf457-f9b0-407c-8a19-583dbaf5711f" xlink:href="endp-20210331.xsd#endp_NonVestedStockOptionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_760e1de4-3665-4774-aed5-ec291d66266f" xlink:to="loc_endp_NonVestedStockOptionsMember_47eaf457-f9b0-407c-8a19-583dbaf5711f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_NonVestedRestrictedStockMember_1e8a1960-ab61-4cb7-8c40-ac4761d07b83" xlink:href="endp-20210331.xsd#endp_NonVestedRestrictedStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_760e1de4-3665-4774-aed5-ec291d66266f" xlink:to="loc_endp_NonVestedRestrictedStockMember_1e8a1960-ab61-4cb7-8c40-ac4761d07b83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d136c835-1301-4feb-be19-c8aefb7a09a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_07ea1749-5fdb-49bf-8ae3-d15797acaaac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d136c835-1301-4feb-be19-c8aefb7a09a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_1c1165b1-d587-4fbe-af2f-25792ffe6e74" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d136c835-1301-4feb-be19-c8aefb7a09a3" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_1c1165b1-d587-4fbe-af2f-25792ffe6e74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_409a79c0-2dca-4d3b-bbb3-5ef5c525b4e0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d136c835-1301-4feb-be19-c8aefb7a09a3" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_409a79c0-2dca-4d3b-bbb3-5ef5c525b4e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_ed92f200-4e74-455a-a677-fa454185a229" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d136c835-1301-4feb-be19-c8aefb7a09a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_ed92f200-4e74-455a-a677-fa454185a229" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/OtherExpenseIncomeNet" xlink:type="simple" xlink:href="endp-20210331.xsd#OtherExpenseIncomeNet"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/OtherExpenseIncomeNet" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAbstract_41d6299d-8317-4088-8b85-6b914db3db80" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock_9ce52a27-3016-484b-8c3a-98cc4219b901" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAbstract_41d6299d-8317-4088-8b85-6b914db3db80" xlink:to="loc_us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock_9ce52a27-3016-484b-8c3a-98cc4219b901" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/OtherExpenseIncomeNetTables" xlink:type="simple" xlink:href="endp-20210331.xsd#OtherExpenseIncomeNetTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/OtherExpenseIncomeNetTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAbstract_2ab5369b-d1a7-4a28-962d-066ab1b0dab6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOtherNonoperatingIncomeByComponentTextBlock_f8fc7b39-15e2-4378-ae59-c37a052f96e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfOtherNonoperatingIncomeByComponentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAbstract_2ab5369b-d1a7-4a28-962d-066ab1b0dab6" xlink:to="loc_us-gaap_ScheduleOfOtherNonoperatingIncomeByComponentTextBlock_f8fc7b39-15e2-4378-ae59-c37a052f96e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/OtherExpenseIncomeNetDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#OtherExpenseIncomeNetDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/OtherExpenseIncomeNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAbstract_2dfc265f-6480-4253-a907-04ffff3d15f0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_GainLossDispositionOfBusinessAndOtherAssets_c7de2c07-af23-4b44-bf10-467fc555b620" xlink:href="endp-20210331.xsd#endp_GainLossDispositionOfBusinessAndOtherAssets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAbstract_2dfc265f-6480-4253-a907-04ffff3d15f0" xlink:to="loc_endp_GainLossDispositionOfBusinessAndOtherAssets_c7de2c07-af23-4b44-bf10-467fc555b620" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_61c79cd3-f6be-4f8d-8534-8d963bbd094e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAbstract_2dfc265f-6480-4253-a907-04ffff3d15f0" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_61c79cd3-f6be-4f8d-8534-8d963bbd094e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_a21737f8-5b20-49cc-9061-d5dd861ab84b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAbstract_2dfc265f-6480-4253-a907-04ffff3d15f0" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_a21737f8-5b20-49cc-9061-d5dd861ab84b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_be22a349-2f34-41a9-a978-95369efd2d7d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAbstract_2dfc265f-6480-4253-a907-04ffff3d15f0" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_be22a349-2f34-41a9-a978-95369efd2d7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_f5e703af-0c0b-4563-8b62-c211068ef7ff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAbstract_2dfc265f-6480-4253-a907-04ffff3d15f0" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_f5e703af-0c0b-4563-8b62-c211068ef7ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/IncomeTaxes" xlink:type="simple" xlink:href="endp-20210331.xsd#IncomeTaxes"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_cb9c7efb-47ae-4bc0-a077-8ed74fc3eee8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_6ca00de9-8fd6-4801-baab-c935d45bf6cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_cb9c7efb-47ae-4bc0-a077-8ed74fc3eee8" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_6ca00de9-8fd6-4801-baab-c935d45bf6cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="endp-20210331.xsd#IncomeTaxesTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/IncomeTaxesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_1acfa4c6-d33e-4ae3-a139-fb6c0bb8f2c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_d41dc16b-968a-407c-8b0a-0d719e39340b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_1acfa4c6-d33e-4ae3-a139-fb6c0bb8f2c5" xlink:to="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_d41dc16b-968a-407c-8b0a-0d719e39340b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/IncomeTaxesLossfromContinuingOperationsandEffectiveTaxRateDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#IncomeTaxesLossfromContinuingOperationsandEffectiveTaxRateDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/IncomeTaxesLossfromContinuingOperationsandEffectiveTaxRateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_5dfcb867-6433-4272-b880-315683b761fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2d433204-909e-43a8-986b-b80b349cf1ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_5dfcb867-6433-4272-b880-315683b761fe" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2d433204-909e-43a8-986b-b80b349cf1ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_c3d45b30-5c3f-4051-a802-ac2c9b149f8a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_5dfcb867-6433-4272-b880-315683b761fe" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_c3d45b30-5c3f-4051-a802-ac2c9b149f8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_58e6bd0a-6716-4967-a699-e2f2d2209f7e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_5dfcb867-6433-4272-b880-315683b761fe" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_58e6bd0a-6716-4967-a699-e2f2d2209f7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_EffectiveIncomeTaxRateReconciliationCARESActAmount_a16d1bea-73a9-40cd-8da1-3dc38b2c2efc" xlink:href="endp-20210331.xsd#endp_EffectiveIncomeTaxRateReconciliationCARESActAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_5dfcb867-6433-4272-b880-315683b761fe" xlink:to="loc_endp_EffectiveIncomeTaxRateReconciliationCARESActAmount_a16d1bea-73a9-40cd-8da1-3dc38b2c2efc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIncomeTaxRefunds_f71a5b32-1a77-4f90-ac7a-711c3f834f5d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIncomeTaxRefunds"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_5dfcb867-6433-4272-b880-315683b761fe" xlink:to="loc_us-gaap_ProceedsFromIncomeTaxRefunds_f71a5b32-1a77-4f90-ac7a-711c3f834f5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/NetIncomePerShare" xlink:type="simple" xlink:href="endp-20210331.xsd#NetIncomePerShare"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/NetIncomePerShare" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_2eb76776-d348-4fe3-938e-54459b5ac09f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_78c7f4ab-fe5f-41f0-9c4c-bd175078ef7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2eb76776-d348-4fe3-938e-54459b5ac09f" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_78c7f4ab-fe5f-41f0-9c4c-bd175078ef7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/NetIncomePerShareTables" xlink:type="simple" xlink:href="endp-20210331.xsd#NetIncomePerShareTables"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/NetIncomePerShareTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_c72fe6e6-e658-4603-b4f5-ab940c40f9be" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_921f8cf2-3e84-40af-b55d-803bf351e50e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_c72fe6e6-e658-4603-b4f5-ab940c40f9be" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_921f8cf2-3e84-40af-b55d-803bf351e50e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/NetIncomePerShareReconciliationOfTheNumeratorAndDenominatorOfBasicAndDilutedNetLossPerShareDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#NetIncomePerShareReconciliationOfTheNumeratorAndDenominatorOfBasicAndDilutedNetLossPerShareDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/NetIncomePerShareReconciliationOfTheNumeratorAndDenominatorOfBasicAndDilutedNetLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_fec3fad6-1799-43aa-9564-5a0eb24b96fb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareReconciliationAbstract_542c2ab5-778f-4959-bd7b-69a758cd9595" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareReconciliationAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_fec3fad6-1799-43aa-9564-5a0eb24b96fb" xlink:to="loc_us-gaap_EarningsPerShareReconciliationAbstract_542c2ab5-778f-4959-bd7b-69a758cd9595" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_b9b4aefe-371d-4d65-99e2-c21ca68c95f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareReconciliationAbstract_542c2ab5-778f-4959-bd7b-69a758cd9595" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_b9b4aefe-371d-4d65-99e2-c21ca68c95f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_1ae6e4d9-a294-4fff-abcc-310ac34c52cd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareReconciliationAbstract_542c2ab5-778f-4959-bd7b-69a758cd9595" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_1ae6e4d9-a294-4fff-abcc-310ac34c52cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2fbd5763-cb7b-4d70-9eaf-27a003e3e0ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareReconciliationAbstract_542c2ab5-778f-4959-bd7b-69a758cd9595" xlink:to="loc_us-gaap_NetIncomeLoss_2fbd5763-cb7b-4d70-9eaf-27a003e3e0ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_fef5543e-f3ac-45dd-a11d-11f1d6271732" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_fec3fad6-1799-43aa-9564-5a0eb24b96fb" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_fef5543e-f3ac-45dd-a11d-11f1d6271732" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_3fb5ec41-4f77-4716-b53a-85b1a40d337a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_fef5543e-f3ac-45dd-a11d-11f1d6271732" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_3fb5ec41-4f77-4716-b53a-85b1a40d337a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_6a4823cd-e2a3-4b58-8e7d-f4bc056d4644" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_fef5543e-f3ac-45dd-a11d-11f1d6271732" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_6a4823cd-e2a3-4b58-8e7d-f4bc056d4644" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_087b0bf8-f142-43fc-8af2-7adea520d4ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_fef5543e-f3ac-45dd-a11d-11f1d6271732" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_087b0bf8-f142-43fc-8af2-7adea520d4ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.endo.com/role/NetIncomePerShareNarrativeDetails" xlink:type="simple" xlink:href="endp-20210331.xsd#NetIncomePerShareNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.endo.com/role/NetIncomePerShareNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_8e110aed-bbf0-4023-bac5-2c7303de8dd2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_f2778ee5-4d30-49f3-a347-beead8323ab4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8e110aed-bbf0-4023-bac5-2c7303de8dd2" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_f2778ee5-4d30-49f3-a347-beead8323ab4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_61cfb9e0-ea0d-4355-997e-4fa5667e2472" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_f2778ee5-4d30-49f3-a347-beead8323ab4" xlink:to="loc_us-gaap_AwardTypeAxis_61cfb9e0-ea0d-4355-997e-4fa5667e2472" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_322c6f21-7fb3-45fb-b0bb-30d243effdb0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_61cfb9e0-ea0d-4355-997e-4fa5667e2472" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_322c6f21-7fb3-45fb-b0bb-30d243effdb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_6bc98be7-89be-45e1-b2e3-f3269688014c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_322c6f21-7fb3-45fb-b0bb-30d243effdb0" xlink:to="loc_us-gaap_EmployeeStockOptionMember_6bc98be7-89be-45e1-b2e3-f3269688014c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_endp_StockAwardMember_8214b8c0-0594-42c6-a2aa-0554832836c7" xlink:href="endp-20210331.xsd#endp_StockAwardMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_322c6f21-7fb3-45fb-b0bb-30d243effdb0" xlink:to="loc_endp_StockAwardMember_8214b8c0-0594-42c6-a2aa-0554832836c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_1b70f869-5fa8-4ee1-84f3-ffff09746d2b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_f2778ee5-4d30-49f3-a347-beead8323ab4" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_1b70f869-5fa8-4ee1-84f3-ffff09746d2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_fe9de889-1170-4680-b026-0af825139c68" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_1b70f869-5fa8-4ee1-84f3-ffff09746d2b" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_fe9de889-1170-4680-b026-0af825139c68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
