<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:239dab97-d4ee-44aa-85fd-4c689d4d0ced,g:b53e7665-4558-489c-aeab-e55dade4bdae-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:endp="http://www.endo.com/20231231" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types1="http://www.xbrl.org/dtr/type/2020-01-21" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2022-03-31" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.endo.com/20231231">
  <xs:import namespace="http://fasb.org/srt/2023" schemaLocation="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd"/>
  <xs:import namespace="http://www.w3.org/1999/xlink" schemaLocation="http://www.xbrl.org/2003/xlink-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2020-01-21" schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/country/2023" schemaLocation="https://xbrl.sec.gov/country/2023/country-2023.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2023" schemaLocation="https://xbrl.sec.gov/dei/2023/dei-2023.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/stpr/2023" schemaLocation="https://xbrl.sec.gov/stpr/2023/stpr-2023.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="endp-20231231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="endp-20231231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="endp-20231231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="endp-20231231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="COVER" roleURI="http://www.endo.com/role/COVER">
        <link:definition>0000001 - Document - COVER</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AuditInformation" roleURI="http://www.endo.com/role/AuditInformation">
        <link:definition>0000002 - Document - Audit Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETS" roleURI="http://www.endo.com/role/CONSOLIDATEDBALANCESHEETS">
        <link:definition>0000003 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETSParenthetical" roleURI="http://www.endo.com/role/CONSOLIDATEDBALANCESHEETSParenthetical">
        <link:definition>0000004 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFOPERATIONS" roleURI="http://www.endo.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS">
        <link:definition>0000005 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" roleURI="http://www.endo.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS">
        <link:definition>0000006 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFSHAREHOLDERSDEFICIT" roleURI="http://www.endo.com/role/CONSOLIDATEDSTATEMENTSOFSHAREHOLDERSDEFICIT">
        <link:definition>0000007 - Statement - CONSOLIDATED STATEMENTS OF SHAREHOLDERS&#8217; DEFICIT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" roleURI="http://www.endo.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS">
        <link:definition>0000008 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESS" roleURI="http://www.endo.com/role/DESCRIPTIONOFBUSINESS">
        <link:definition>0000009 - Disclosure - DESCRIPTION OF BUSINESS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BANKRUPTCYPROCEEDINGS" roleURI="http://www.endo.com/role/BANKRUPTCYPROCEEDINGS">
        <link:definition>0000010 - Disclosure - BANKRUPTCY PROCEEDINGS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES" roleURI="http://www.endo.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES">
        <link:definition>0000011 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSANDASSETSSALES" roleURI="http://www.endo.com/role/DISCONTINUEDOPERATIONSANDASSETSSALES">
        <link:definition>0000012 - Disclosure - DISCONTINUED OPERATIONS AND ASSETS SALES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RESTRUCTURING" roleURI="http://www.endo.com/role/RESTRUCTURING">
        <link:definition>0000013 - Disclosure - RESTRUCTURING</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTRESULTS" roleURI="http://www.endo.com/role/SEGMENTRESULTS">
        <link:definition>0000014 - Disclosure - SEGMENT RESULTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTS" roleURI="http://www.endo.com/role/FAIRVALUEMEASUREMENTS">
        <link:definition>0000015 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORIES" roleURI="http://www.endo.com/role/INVENTORIES">
        <link:definition>0000016 - Disclosure - INVENTORIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASES" roleURI="http://www.endo.com/role/LEASES">
        <link:definition>0000017 - Disclosure - LEASES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PROPERTYPLANTANDEQUIPMENT" roleURI="http://www.endo.com/role/PROPERTYPLANTANDEQUIPMENT">
        <link:definition>0000018 - Disclosure - PROPERTY, PLANT AND EQUIPMENT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLES" roleURI="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLES">
        <link:definition>0000019 - Disclosure - GOODWILL AND OTHER INTANGIBLES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LICENSECOLLABORATIONANDASSETACQUISITIONAGREEMENTS" roleURI="http://www.endo.com/role/LICENSECOLLABORATIONANDASSETACQUISITIONAGREEMENTS">
        <link:definition>0000020 - Disclosure - LICENSE, COLLABORATION AND ASSET ACQUISITION AGREEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONTRACTASSETSANDLIABILITIES" roleURI="http://www.endo.com/role/CONTRACTASSETSANDLIABILITIES">
        <link:definition>0000021 - Disclosure - CONTRACT ASSETS AND LIABILITIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCOUNTSPAYABLEANDACCRUEDEXPENSES" roleURI="http://www.endo.com/role/ACCOUNTSPAYABLEANDACCRUEDEXPENSES">
        <link:definition>0000022 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED EXPENSES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBT" roleURI="http://www.endo.com/role/DEBT">
        <link:definition>0000023 - Disclosure - DEBT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIES" roleURI="http://www.endo.com/role/COMMITMENTSANDCONTINGENCIES">
        <link:definition>0000024 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OTHERCOMPREHENSIVEINCOMELOSS" roleURI="http://www.endo.com/role/OTHERCOMPREHENSIVEINCOMELOSS">
        <link:definition>0000025 - Disclosure - OTHER COMPREHENSIVE INCOME (LOSS)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREHOLDERSDEFICIT" roleURI="http://www.endo.com/role/SHAREHOLDERSDEFICIT">
        <link:definition>0000026 - Disclosure - SHAREHOLDERS&#8217; DEFICIT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATION" roleURI="http://www.endo.com/role/SHAREBASEDCOMPENSATION">
        <link:definition>0000027 - Disclosure - SHARE-BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OTHERINCOMENET" roleURI="http://www.endo.com/role/OTHERINCOMENET">
        <link:definition>0000028 - Disclosure - OTHER INCOME, NET</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXES" roleURI="http://www.endo.com/role/INCOMETAXES">
        <link:definition>0000029 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERSHARE" roleURI="http://www.endo.com/role/NETLOSSPERSHARE">
        <link:definition>0000030 - Disclosure - NET LOSS PER SHARE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATION" roleURI="http://www.endo.com/role/CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATION">
        <link:definition>0000031 - Disclosure - CONDENSED COMBINED DEBTOR-IN-POSSESSION FINANCIAL INFORMATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SAVINGSANDINVESTMENTPLANANDDEFERREDCOMPENSATIONPLANS" roleURI="http://www.endo.com/role/SAVINGSANDINVESTMENTPLANANDDEFERREDCOMPENSATIONPLANS">
        <link:definition>0000032 - Disclosure - SAVINGS AND INVESTMENT PLAN AND DEFERRED COMPENSATION PLANS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SCHEDULEIIVALUATIONANDQUALIFYINGACCOUNTS" roleURI="http://www.endo.com/role/SCHEDULEIIVALUATIONANDQUALIFYINGACCOUNTS">
        <link:definition>0000033 - Disclosure - SCHEDULE II&#8212;VALUATION AND QUALIFYING ACCOUNTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies" roleURI="http://www.endo.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies">
        <link:definition>9954471 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BANKRUPTCYPROCEEDINGSTables" roleURI="http://www.endo.com/role/BANKRUPTCYPROCEEDINGSTables">
        <link:definition>9954472 - Disclosure - BANKRUPTCY PROCEEDINGS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables" roleURI="http://www.endo.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables">
        <link:definition>9954473 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSANDASSETSSALESTables" roleURI="http://www.endo.com/role/DISCONTINUEDOPERATIONSANDASSETSSALESTables">
        <link:definition>9954474 - Disclosure - DISCONTINUED OPERATIONS AND ASSETS SALES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RESTRUCTURINGTables" roleURI="http://www.endo.com/role/RESTRUCTURINGTables">
        <link:definition>9954475 - Disclosure - RESTRUCTURING (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTRESULTSTables" roleURI="http://www.endo.com/role/SEGMENTRESULTSTables">
        <link:definition>9954476 - Disclosure - SEGMENT RESULTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSTables" roleURI="http://www.endo.com/role/FAIRVALUEMEASUREMENTSTables">
        <link:definition>9954477 - Disclosure - FAIR VALUE MEASUREMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORIESTables" roleURI="http://www.endo.com/role/INVENTORIESTables">
        <link:definition>9954478 - Disclosure - INVENTORIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESTables" roleURI="http://www.endo.com/role/LEASESTables">
        <link:definition>9954479 - Disclosure - LEASES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PROPERTYPLANTANDEQUIPMENTTables" roleURI="http://www.endo.com/role/PROPERTYPLANTANDEQUIPMENTTables">
        <link:definition>9954480 - Disclosure - PROPERTY, PLANT AND EQUIPMENT (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLESTables" roleURI="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLESTables">
        <link:definition>9954481 - Disclosure - GOODWILL AND OTHER INTANGIBLES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONTRACTASSETSANDLIABILITIESTables" roleURI="http://www.endo.com/role/CONTRACTASSETSANDLIABILITIESTables">
        <link:definition>9954482 - Disclosure - CONTRACT ASSETS AND LIABILITIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCOUNTSPAYABLEANDACCRUEDEXPENSESTables" roleURI="http://www.endo.com/role/ACCOUNTSPAYABLEANDACCRUEDEXPENSESTables">
        <link:definition>9954483 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTTables" roleURI="http://www.endo.com/role/DEBTTables">
        <link:definition>9954484 - Disclosure - DEBT (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESTables" roleURI="http://www.endo.com/role/COMMITMENTSANDCONTINGENCIESTables">
        <link:definition>9954485 - Disclosure - COMMITMENTS AND CONTINGENCIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONTables" roleURI="http://www.endo.com/role/SHAREBASEDCOMPENSATIONTables">
        <link:definition>9954486 - Disclosure - SHARE-BASED COMPENSATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OTHERINCOMENETTables" roleURI="http://www.endo.com/role/OTHERINCOMENETTables">
        <link:definition>9954487 - Disclosure - OTHER INCOME, NET (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESTables" roleURI="http://www.endo.com/role/INCOMETAXESTables">
        <link:definition>9954488 - Disclosure - INCOME TAXES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERSHARETables" roleURI="http://www.endo.com/role/NETLOSSPERSHARETables">
        <link:definition>9954489 - Disclosure - NET LOSS PER SHARE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONTables" roleURI="http://www.endo.com/role/CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONTables">
        <link:definition>9954490 - Disclosure - CONDENSED COMBINED DEBTOR-IN-POSSESSION FINANCIAL INFORMATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BANKRUPTCYPROCEEDINGSNarrativeDetails" roleURI="http://www.endo.com/role/BANKRUPTCYPROCEEDINGSNarrativeDetails">
        <link:definition>9954491 - Disclosure - BANKRUPTCY PROCEEDINGS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BANKRUPTCYPROCEEDINGSLiabilitiesSubjecttoCompromiseDetails" roleURI="http://www.endo.com/role/BANKRUPTCYPROCEEDINGSLiabilitiesSubjecttoCompromiseDetails">
        <link:definition>9954492 - Disclosure - BANKRUPTCY PROCEEDINGS - Liabilities Subject to Compromise (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BANKRUPTCYPROCEEDINGSReorganizationItemsDetails" roleURI="http://www.endo.com/role/BANKRUPTCYPROCEEDINGSReorganizationItemsDetails">
        <link:definition>9954493 - Disclosure - BANKRUPTCY PROCEEDINGS - Reorganization Items (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESConsolidatedRevenueDetails" roleURI="http://www.endo.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESConsolidatedRevenueDetails">
        <link:definition>9954494 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Consolidated Revenue (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESRevenueRecognitionandConcentrationsofCreditRiskandCreditLossesDetails" roleURI="http://www.endo.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESRevenueRecognitionandConcentrationsofCreditRiskandCreditLossesDetails">
        <link:definition>9954495 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Revenue Recognition and Concentrations of Credit Risk and Credit Losses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPropertyPlantandEquipmentDevelopedTechnologyandLicenseRightsDetails" roleURI="http://www.endo.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPropertyPlantandEquipmentDevelopedTechnologyandLicenseRightsDetails">
        <link:definition>9954496 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Property, Plant and Equipment, Developed Technology and License Rights (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAdvertisingCostsDetails" roleURI="http://www.endo.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAdvertisingCostsDetails">
        <link:definition>9954497 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Advertising Costs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSANDASSETSSALESAstoraDiscontinuedOperationsDetails" roleURI="http://www.endo.com/role/DISCONTINUEDOPERATIONSANDASSETSSALESAstoraDiscontinuedOperationsDetails">
        <link:definition>9954498 - Disclosure - DISCONTINUED OPERATIONS AND ASSETS SALES - Astora - Discontinued Operations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSANDASSETSSALESNarrativeDetails" roleURI="http://www.endo.com/role/DISCONTINUEDOPERATIONSANDASSETSSALESNarrativeDetails">
        <link:definition>9954499 - Disclosure - DISCONTINUED OPERATIONS AND ASSETS SALES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RESTRUCTURINGNarrativeDetails" roleURI="http://www.endo.com/role/RESTRUCTURINGNarrativeDetails">
        <link:definition>9954500 - Disclosure - RESTRUCTURING - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RESTRUCTURINGPretaxNetChargesDetails" roleURI="http://www.endo.com/role/RESTRUCTURINGPretaxNetChargesDetails">
        <link:definition>9954501 - Disclosure - RESTRUCTURING - Pre-tax Net Charges (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RESTRUCTURINGPretaxNetChargesIncludedintheCondensedConsolidatedStatementofOperationsDetails" roleURI="http://www.endo.com/role/RESTRUCTURINGPretaxNetChargesIncludedintheCondensedConsolidatedStatementofOperationsDetails">
        <link:definition>9954502 - Disclosure - RESTRUCTURING - Pre-tax Net Charges Included in the Condensed Consolidated Statement of Operations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RESTRUCTURINGChangestotheLiabilityDetails" roleURI="http://www.endo.com/role/RESTRUCTURINGChangestotheLiabilityDetails">
        <link:definition>9954503 - Disclosure - RESTRUCTURING - Changes to the Liability (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTRESULTSNarrativeDetails" roleURI="http://www.endo.com/role/SEGMENTRESULTSNarrativeDetails">
        <link:definition>9954504 - Disclosure - SEGMENT RESULTS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTRESULTSScheduleofReportableSegmentsInformationDetails" roleURI="http://www.endo.com/role/SEGMENTRESULTSScheduleofReportableSegmentsInformationDetails">
        <link:definition>9954505 - Disclosure - SEGMENT RESULTS - Schedule of Reportable Segments Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTRESULTSScheduleofReconciliationsofConsolidatedAdjustedLossBeforeIncomeTaxDetails" roleURI="http://www.endo.com/role/SEGMENTRESULTSScheduleofReconciliationsofConsolidatedAdjustedLossBeforeIncomeTaxDetails">
        <link:definition>9954506 - Disclosure - SEGMENT RESULTS - Schedule of Reconciliations of Consolidated Adjusted Loss Before Income Tax (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTRESULTSScheduleofDisaggregationofRevenuesDetails" roleURI="http://www.endo.com/role/SEGMENTRESULTSScheduleofDisaggregationofRevenuesDetails">
        <link:definition>9954507 - Disclosure - SEGMENT RESULTS - Schedule of Disaggregation of Revenues (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTRESULTSScheduleofDepreciationExpensesDetails" roleURI="http://www.endo.com/role/SEGMENTRESULTSScheduleofDepreciationExpensesDetails">
        <link:definition>9954508 - Disclosure - SEGMENT RESULTS- Schedule of Depreciation Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSRestrictedCashandCashEquivalentsDetails" roleURI="http://www.endo.com/role/FAIRVALUEMEASUREMENTSRestrictedCashandCashEquivalentsDetails">
        <link:definition>9954509 - Disclosure - FAIR VALUE MEASUREMENTS - Restricted Cash and Cash Equivalents (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails" roleURI="http://www.endo.com/role/FAIRVALUEMEASUREMENTSFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails">
        <link:definition>9954510 - Disclosure - FAIR VALUE MEASUREMENTS - Financial Assets And Liabilities Measured At Fair Value On Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSFinancialLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingSignificantUnobservableInputsDetails" roleURI="http://www.endo.com/role/FAIRVALUEMEASUREMENTSFinancialLiabilitiesMeasuredAtFairValueOnRecurringBasisUsingSignificantUnobservableInputsDetails">
        <link:definition>9954511 - Disclosure - FAIR VALUE MEASUREMENTS - Financial Liabilities Measured At Fair Value On Recurring Basis Using Significant Unobservable Inputs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSNarrativeDetails" roleURI="http://www.endo.com/role/FAIRVALUEMEASUREMENTSNarrativeDetails">
        <link:definition>9954512 - Disclosure - FAIR VALUE MEASUREMENTS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofFinancialAssetsMeasuredAtFairValueOnANonrecurringBasisDetails" roleURI="http://www.endo.com/role/FAIRVALUEMEASUREMENTSScheduleofFinancialAssetsMeasuredAtFairValueOnANonrecurringBasisDetails">
        <link:definition>9954513 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of Financial Assets Measured At Fair Value On A Nonrecurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORIESScheduleofInventoryDetails" roleURI="http://www.endo.com/role/INVENTORIESScheduleofInventoryDetails">
        <link:definition>9954514 - Disclosure - INVENTORIES - Schedule of Inventory (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORIESNarrativeDetails" roleURI="http://www.endo.com/role/INVENTORIESNarrativeDetails">
        <link:definition>9954515 - Disclosure - INVENTORIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESAssetsandLiabilitiesDetails" roleURI="http://www.endo.com/role/LEASESAssetsandLiabilitiesDetails">
        <link:definition>9954516 - Disclosure - LEASES - Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESComponentsofLeaseExpenseDetails" roleURI="http://www.endo.com/role/LEASESComponentsofLeaseExpenseDetails">
        <link:definition>9954517 - Disclosure - LEASES - Components of Lease Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESFutureCashFlowsIncludedInOurLeaseLiabilitiesDetails" roleURI="http://www.endo.com/role/LEASESFutureCashFlowsIncludedInOurLeaseLiabilitiesDetails">
        <link:definition>9954518 - Disclosure - LEASES - Future Cash Flows Included In Our Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESFutureCashFlowsIncludedInOurLeaseLiabilitiesDetails_1" roleURI="http://www.endo.com/role/LEASESFutureCashFlowsIncludedInOurLeaseLiabilitiesDetails_1">
        <link:definition>9954518 - Disclosure - LEASES - Future Cash Flows Included In Our Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESFutureCashFlowsIncludedInOurLeaseLiabilitiesDetails_2" roleURI="http://www.endo.com/role/LEASESFutureCashFlowsIncludedInOurLeaseLiabilitiesDetails_2">
        <link:definition>9954518 - Disclosure - LEASES - Future Cash Flows Included In Our Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESWeightedAverageRemainingLeaseTermAndWeightedAverageDiscountRatesDetails" roleURI="http://www.endo.com/role/LEASESWeightedAverageRemainingLeaseTermAndWeightedAverageDiscountRatesDetails">
        <link:definition>9954519 - Disclosure - LEASES - Weighted Average Remaining Lease Term And Weighted Average Discount Rates (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESCashFlowandSupplementalNoncashInformationDetails" roleURI="http://www.endo.com/role/LEASESCashFlowandSupplementalNoncashInformationDetails">
        <link:definition>9954520 - Disclosure - LEASES - Cash Flow and Supplemental Noncash Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PROPERTYPLANTANDEQUIPMENTDetails" roleURI="http://www.endo.com/role/PROPERTYPLANTANDEQUIPMENTDetails">
        <link:definition>9954521 - Disclosure - PROPERTY, PLANT AND EQUIPMENT (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PROPERTYPLANTANDEQUIPMENTNarrativeDetails" roleURI="http://www.endo.com/role/PROPERTYPLANTANDEQUIPMENTNarrativeDetails">
        <link:definition>9954522 - Disclosure - PROPERTY, PLANT AND EQUIPMENT - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLESChangesintheCarryingAmountofGoodwillDetails" roleURI="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLESChangesintheCarryingAmountofGoodwillDetails">
        <link:definition>9954523 - Disclosure - GOODWILL AND OTHER INTANGIBLES - Changes in the Carrying Amount of Goodwill (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLESAccumulatedImpairmentDetails" roleURI="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLESAccumulatedImpairmentDetails">
        <link:definition>9954524 - Disclosure - GOODWILL AND OTHER INTANGIBLES - Accumulated Impairment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLESOtherIntangibleAssetsDetails" roleURI="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLESOtherIntangibleAssetsDetails">
        <link:definition>9954525 - Disclosure - GOODWILL AND OTHER INTANGIBLES - Other Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLESNarrativeDetails" roleURI="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLESNarrativeDetails">
        <link:definition>9954526 - Disclosure - GOODWILL AND OTHER INTANGIBLES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GOODWILLANDOTHERINTANGIBLESScheduleofEstimatedAmortizationofIntangiblesDetails" roleURI="http://www.endo.com/role/GOODWILLANDOTHERINTANGIBLESScheduleofEstimatedAmortizationofIntangiblesDetails">
        <link:definition>9954527 - Disclosure - GOODWILL AND OTHER INTANGIBLES - Schedule of Estimated Amortization of Intangibles (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LICENSECOLLABORATIONANDASSETACQUISITIONAGREEMENTSDetails" roleURI="http://www.endo.com/role/LICENSECOLLABORATIONANDASSETACQUISITIONAGREEMENTSDetails">
        <link:definition>9954528 - Disclosure - LICENSE, COLLABORATION AND ASSET ACQUISITION AGREEMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONTRACTASSETSANDLIABILITIESContractAssetsandContractLiabilitiesfromContractswithCustomersDetails" roleURI="http://www.endo.com/role/CONTRACTASSETSANDLIABILITIESContractAssetsandContractLiabilitiesfromContractswithCustomersDetails">
        <link:definition>9954529 - Disclosure - CONTRACT ASSETS AND LIABILITIES - Contract Assets and Contract Liabilities from Contracts with Customers (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONTRACTASSETSANDLIABILITIESNarrativeDetails" roleURI="http://www.endo.com/role/CONTRACTASSETSANDLIABILITIESNarrativeDetails">
        <link:definition>9954530 - Disclosure - CONTRACT ASSETS AND LIABILITIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCOUNTSPAYABLEANDACCRUEDEXPENSESScheduleofAccountsPayableandAccruedLiabilitiesDetails" roleURI="http://www.endo.com/role/ACCOUNTSPAYABLEANDACCRUEDEXPENSESScheduleofAccountsPayableandAccruedLiabilitiesDetails">
        <link:definition>9954531 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED EXPENSES - Schedule of Accounts Payable and Accrued Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTComponentsofTotalIndebtednessDetails" roleURI="http://www.endo.com/role/DEBTComponentsofTotalIndebtednessDetails">
        <link:definition>9954532 - Disclosure - DEBT - Components of Total Indebtedness (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTNarrativeDetails" roleURI="http://www.endo.com/role/DEBTNarrativeDetails">
        <link:definition>9954533 - Disclosure - DEBT - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTCreditFacilityDetails" roleURI="http://www.endo.com/role/DEBTCreditFacilityDetails">
        <link:definition>9954534 - Disclosure - DEBT - Credit Facility (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTCovenantsandEventsofDefaultDetails" roleURI="http://www.endo.com/role/DEBTCovenantsandEventsofDefaultDetails">
        <link:definition>9954535 - Disclosure - DEBT - Covenants and Events of Default (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTDebtFinancingTransactionsDetails" roleURI="http://www.endo.com/role/DEBTDebtFinancingTransactionsDetails">
        <link:definition>9954536 - Disclosure - DEBT - Debt Financing Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTMaturitiesofLongTermDebtDetails" roleURI="http://www.endo.com/role/DEBTMaturitiesofLongTermDebtDetails">
        <link:definition>9954537 - Disclosure - DEBT - Maturities of Long-Term Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTMaturitiesofLongTermDebtNarrativeDetails" roleURI="http://www.endo.com/role/DEBTMaturitiesofLongTermDebtNarrativeDetails">
        <link:definition>9954538 - Disclosure - DEBT - Maturities of Long-Term Debt - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESNarrativeDetails" roleURI="http://www.endo.com/role/COMMITMENTSANDCONTINGENCIESNarrativeDetails">
        <link:definition>9954539 - Disclosure - COMMITMENTS AND CONTINGENCIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESScheduleofDeferredIncomeDetails" roleURI="http://www.endo.com/role/COMMITMENTSANDCONTINGENCIESScheduleofDeferredIncomeDetails">
        <link:definition>9954540 - Disclosure - COMMITMENTS AND CONTINGENCIES - Schedule of Deferred Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESScheduleofLossContingenciesDetails" roleURI="http://www.endo.com/role/COMMITMENTSANDCONTINGENCIESScheduleofLossContingenciesDetails">
        <link:definition>9954541 - Disclosure - COMMITMENTS AND CONTINGENCIES - Schedule of Loss Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OTHERCOMPREHENSIVEINCOMELOSSDetails" roleURI="http://www.endo.com/role/OTHERCOMPREHENSIVEINCOMELOSSDetails">
        <link:definition>9954542 - Disclosure - OTHER COMPREHENSIVE INCOME (LOSS) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREHOLDERSDEFICITDetails" roleURI="http://www.endo.com/role/SHAREHOLDERSDEFICITDetails">
        <link:definition>9954543 - Disclosure - SHAREHOLDERS&#8217; DEFICIT (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONNarrativeDetails" roleURI="http://www.endo.com/role/SHAREBASEDCOMPENSATIONNarrativeDetails">
        <link:definition>9954544 - Disclosure - SHARE-BASED COMPENSATION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONAllocationofStockBasedCompensationDetails" roleURI="http://www.endo.com/role/SHAREBASEDCOMPENSATIONAllocationofStockBasedCompensationDetails">
        <link:definition>9954545 - Disclosure - SHARE-BASED COMPENSATION - Allocation of Stock-Based Compensation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONActivityUnderStockIncentivePlansDetails" roleURI="http://www.endo.com/role/SHAREBASEDCOMPENSATIONActivityUnderStockIncentivePlansDetails">
        <link:definition>9954546 - Disclosure - SHARE-BASED COMPENSATION - Activity Under Stock Incentive Plans (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONActivityUnderStockIncentivePlansDetails_1" roleURI="http://www.endo.com/role/SHAREBASEDCOMPENSATIONActivityUnderStockIncentivePlansDetails_1">
        <link:definition>9954547 - Disclosure - SHARE-BASED COMPENSATION - Activity Under Stock Incentive Plans (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OTHERINCOMENETScheduleofComponentsofOtherExpenseNetDetails" roleURI="http://www.endo.com/role/OTHERINCOMENETScheduleofComponentsofOtherExpenseNetDetails">
        <link:definition>9954548 - Disclosure - OTHER INCOME, NET - Schedule of Components of Other Expense, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESIncomebeforeIncomeTaxDomesticandForeignDetails" roleURI="http://www.endo.com/role/INCOMETAXESIncomebeforeIncomeTaxDomesticandForeignDetails">
        <link:definition>9954549 - Disclosure - INCOME TAXES - Income before Income Tax, Domestic and Foreign (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESScheduleofComponentsofIncomeTaxExpenseBenefitDetails" roleURI="http://www.endo.com/role/INCOMETAXESScheduleofComponentsofIncomeTaxExpenseBenefitDetails">
        <link:definition>9954550 - Disclosure - INCOME TAXES - Schedule of Components of Income Tax Expense (Benefit) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESEffectiveIncomeTaxRateReconciliationDetails" roleURI="http://www.endo.com/role/INCOMETAXESEffectiveIncomeTaxRateReconciliationDetails">
        <link:definition>9954551 - Disclosure - INCOME TAXES - Effective Income Tax Rate Reconciliation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESDeferredTaxAssetsandLiabilitiesDetails" roleURI="http://www.endo.com/role/INCOMETAXESDeferredTaxAssetsandLiabilitiesDetails">
        <link:definition>9954552 - Disclosure - INCOME TAXES - Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESTaxCreditCarryforwardsDetails" roleURI="http://www.endo.com/role/INCOMETAXESTaxCreditCarryforwardsDetails">
        <link:definition>9954553 - Disclosure - INCOME TAXES - Tax Credit Carryforwards (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESNarrativeDetails" roleURI="http://www.endo.com/role/INCOMETAXESNarrativeDetails">
        <link:definition>9954554 - Disclosure - INCOME TAXES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESValuationAllowanceDetails" roleURI="http://www.endo.com/role/INCOMETAXESValuationAllowanceDetails">
        <link:definition>9954555 - Disclosure - INCOME TAXES - Valuation Allowance (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESUnrecognizedTaxBenefitsRollForwardDetails" roleURI="http://www.endo.com/role/INCOMETAXESUnrecognizedTaxBenefitsRollForwardDetails">
        <link:definition>9954556 - Disclosure - INCOME TAXES - Unrecognized Tax Benefits Roll Forward (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERSHAREReconciliationoftheNumeratorandDenominatorofBasicandDilutedNetLossIncomePerShareDetails" roleURI="http://www.endo.com/role/NETLOSSPERSHAREReconciliationoftheNumeratorandDenominatorofBasicandDilutedNetLossIncomePerShareDetails">
        <link:definition>9954557 - Disclosure - NET LOSS PER SHARE - Reconciliation of the Numerator and Denominator of Basic and Diluted Net (Loss) Income Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERSHAREComputationofDilutedIncomePerShareDetails" roleURI="http://www.endo.com/role/NETLOSSPERSHAREComputationofDilutedIncomePerShareDetails">
        <link:definition>9954558 - Disclosure - NET LOSS PER SHARE - Computation of Diluted Income Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDBALANCESHEETSDetails" roleURI="http://www.endo.com/role/CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDBALANCESHEETSDetails">
        <link:definition>9954559 - Disclosure - CONDENSED COMBINED DEBTOR-IN-POSSESSION FINANCIAL INFORMATION- CONDENSED COMBINED BALANCE SHEETS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFOPERATIONSDetails" roleURI="http://www.endo.com/role/CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFOPERATIONSDetails">
        <link:definition>9954560 - Disclosure - CONDENSED COMBINED DEBTOR-IN-POSSESSION FINANCIAL INFORMATION - CONDENSED COMBINED STATEMENTS OF OPERATIONS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFCOMPREHENSIVEINCOMEDetails" roleURI="http://www.endo.com/role/CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFCOMPREHENSIVEINCOMEDetails">
        <link:definition>9954561 - Disclosure - CONDENSED COMBINED DEBTOR-IN-POSSESSION FINANCIAL INFORMATION-CONDENSED COMBINED STATEMENTS OF COMPREHENSIVE INCOME (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFCASHFLOWSDetails" roleURI="http://www.endo.com/role/CONDENSEDCOMBINEDDEBTORINPOSSESSIONFINANCIALINFORMATIONCONDENSEDCOMBINEDSTATEMENTSOFCASHFLOWSDetails">
        <link:definition>9954562 - Disclosure - CONDENSED COMBINED DEBTOR-IN-POSSESSION FINANCIAL INFORMATION-CONDENSED COMBINED STATEMENTS OF CASH FLOWS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SAVINGSANDINVESTMENTPLANANDDEFERREDCOMPENSATIONPLANSDetails" roleURI="http://www.endo.com/role/SAVINGSANDINVESTMENTPLANANDDEFERREDCOMPENSATIONPLANSDetails">
        <link:definition>9954563 - Disclosure - SAVINGS AND INVESTMENT PLAN AND DEFERRED COMPENSATION PLANS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SCHEDULEIIVALUATIONANDQUALIFYINGACCOUNTSDetails" roleURI="http://www.endo.com/role/SCHEDULEIIVALUATIONANDQUALIFYINGACCOUNTSDetails">
        <link:definition>9954564 - Disclosure - SCHEDULE II&#8212;VALUATION AND QUALIFYING ACCOUNTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="endp_EndosPortionOfCostsIncludedInPropertyPlantAndEquipmentNet" abstract="false" name="EndosPortionOfCostsIncludedInPropertyPlantAndEquipmentNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember" abstract="true" name="SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_FiniteLivedIntangibleAssetsOtherEffectOnAccumulatedAmortization" abstract="false" name="FiniteLivedIntangibleAssetsOtherEffectOnAccumulatedAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_RestrictedStockUnitsAndPerformanceStockUnitsMember" abstract="true" name="RestrictedStockUnitsAndPerformanceStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_EuroDeferredStockValueIssued" abstract="false" name="EuroDeferredStockValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_OtherEstablishedProductsMember" abstract="true" name="OtherEstablishedProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_MinimumOwnershipPercentageOfOutstandingSecuredDebtThresholdPercentage" abstract="false" name="MinimumOwnershipPercentageOfOutstandingSecuredDebtThresholdPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseOperatingAndFinanceLeaseLiability" abstract="false" name="LiabilitiesSubjectToCompromiseOperatingAndFinanceLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_ExpensesRelatedToEquityAgreementCancellation" abstract="false" name="ExpensesRelatedToEquityAgreementCancellation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AssetAcquisitionsPolicyPolicyTextBlock" abstract="false" name="AssetAcquisitionsPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_ScheduleOfGoodwillAndOtherIntangiblesTable" abstract="true" name="ScheduleOfGoodwillAndOtherIntangiblesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="endp_FinancingLeaseLiabilitiesIncludingAmountsClassifiedAsLiabilitiesSubjectToCompromise" abstract="false" name="FinancingLeaseLiabilitiesIncludingAmountsClassifiedAsLiabilitiesSubjectToCompromise" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DeferredTaxLiabilityIntercompanyNotes" abstract="false" name="DeferredTaxLiabilityIntercompanyNotes" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EffectiveIncomeTaxRateReconciliationNonDeductibleLegalSettlement" abstract="false" name="EffectiveIncomeTaxRateReconciliationNonDeductibleLegalSettlement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" abstract="false" name="LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_CriminalForfeitureJudgment" abstract="false" name="CriminalForfeitureJudgment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember" abstract="true" name="EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SettlementFunds" abstract="false" name="SettlementFunds" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DisposalGroupIncludingDiscontinuedOperationNonCashConsideration" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationNonCashConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_MeshRelatedCasesMember" abstract="true" name="MeshRelatedCasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_RestructuringInitiative2020Member" abstract="true" name="RestructuringInitiative2020Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_OpiodClaimantsMember" abstract="true" name="OpiodClaimantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_TwoThousandFifteenStockIncentivePlanMember" abstract="true" name="TwoThousandFifteenStockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseUncertainTaxPositions" abstract="false" name="LiabilitiesSubjectToCompromiseUncertainTaxPositions" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SterileInjectablesSegmentMember" abstract="true" name="SterileInjectablesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_AccruedLiabilitiesRebatesCurrent" abstract="false" name="AccruedLiabilitiesRebatesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_CencoraIncMember" abstract="false" name="CencoraIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SpecialtyProductsMember" abstract="true" name="SpecialtyProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVest" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVest" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="endp_DebtorInPossessionTypeAxisAxis" abstract="true" name="DebtorInPossessionTypeAxisAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="endp_PlanOfReorganizationSubjectToPrepaymentRightsFutureOpioidClaimants" abstract="false" name="PlanOfReorganizationSubjectToPrepaymentRightsFutureOpioidClaimants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_OperatingAndFinanceLeasesAmountsClassifiedAsLiabilitiesSubjectToCompromiseAbstract" abstract="true" name="OperatingAndFinanceLeasesAmountsClassifiedAsLiabilitiesSubjectToCompromiseAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_ComputerEquipmentAndSoftwareMember" abstract="true" name="ComputerEquipmentAndSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PlanOfReorganizationOfferRightsParticipationAmount" abstract="false" name="PlanOfReorganizationOfferRightsParticipationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_OperatingLeaseLiabilitiesIncludingAmountsClassifiedAsLiabilitiesSubjectToCompromise" abstract="false" name="OperatingLeaseLiabilitiesIncludingAmountsClassifiedAsLiabilitiesSubjectToCompromise" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AssetsUnderConstructionGross" abstract="false" name="AssetsUnderConstructionGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_UnrecognizedTaxBenefitsIncludingInterestAndPenalties" abstract="false" name="UnrecognizedTaxBenefitsIncludingInterestAndPenalties" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SixPercentSeniorNotesDueTwoThousandTwentyFiveMember" abstract="true" name="SixPercentSeniorNotesDueTwoThousandTwentyFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_CumulativeGrantProceedsReceivedToReimburseAssetConstruction" abstract="false" name="CumulativeGrantProceedsReceivedToReimburseAssetConstruction" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PlanOfReorganizationCashSettlementToBePaid" abstract="false" name="PlanOfReorganizationCashSettlementToBePaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PlanOfReorganizationSubjectToPrepaymentRightsPrivateOpioidClaimants" abstract="false" name="PlanOfReorganizationSubjectToPrepaymentRightsPrivateOpioidClaimants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_ProceedsFromUSGovernmentAgreement" abstract="false" name="ProceedsFromUSGovernmentAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_HostingArrangementServiceContractPolicyTextBlock" abstract="false" name="HostingArrangementServiceContractPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_LeaseLiabilitiesArisingFromObtainingRightOfUseAssetsAbstract" abstract="true" name="LeaseLiabilitiesArisingFromObtainingRightOfUseAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_LitigationSettlementSubsequentSettlementPayment" abstract="false" name="LitigationSettlementSubsequentSettlementPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_ScheduleOfStockholdersEquityTable" abstract="true" name="ScheduleOfStockholdersEquityTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="endp_VasostrictMember" abstract="true" name="VasostrictMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_RevenueFromContractWithCustomerReturnPeriod" abstract="false" name="RevenueFromContractWithCustomerReturnPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_DefinedContributionPlanEmployersMatchingContributionVestingTerm" abstract="false" name="DefinedContributionPlanEmployersMatchingContributionVestingTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_ScheduleOfReorganisationItemInConsolidatedCondensedStatementsOfOperationsTableTextBlock" abstract="false" name="ScheduleOfReorganisationItemInConsolidatedCondensedStatementsOfOperationsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseFinanceLeaseLiability" abstract="false" name="LiabilitiesSubjectToCompromiseFinanceLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AuxiliumPharmaceuticalsInc.Member" abstract="true" name="AuxiliumPharmaceuticalsInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SettlementFundsOther" abstract="false" name="SettlementFundsOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PotentialSettlementMadeInCash" abstract="false" name="PotentialSettlementMadeInCash" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_NumberOfProductLicenses" abstract="false" name="NumberOfProductLicenses" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_AcquisitionsIncurredButNotYetPaid" abstract="false" name="AcquisitionsIncurredButNotYetPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyPlaintiffsNumberOfCounties" abstract="false" name="LossContingencyPlaintiffsNumberOfCounties" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_EHSICriminalFine" abstract="false" name="EHSICriminalFine" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseOperatingLeaseLiability" abstract="false" name="LiabilitiesSubjectToCompromiseOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_GainLossFromPriorContractDispute" abstract="false" name="GainLossFromPriorContractDispute" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_CARESActMember" abstract="true" name="CARESActMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_ResolutionSettlementGrossConsiderationPayableInInstallments" abstract="false" name="ResolutionSettlementGrossConsiderationPayableInInstallments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_EstablishedProductsMember" abstract="true" name="EstablishedProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PotentialSettlementFeesCap" abstract="false" name="PotentialSettlementFeesCap" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PotentialSettlementMadeInEquityPercentage" abstract="false" name="PotentialSettlementMadeInEquityPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_CostReductionMember" abstract="true" name="CostReductionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PlanOfReorganizationCommitmentConsideration" abstract="false" name="PlanOfReorganizationCommitmentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PlanOfReorganizationAdditionalCommitmentIfEBITDAExceed" abstract="false" name="PlanOfReorganizationAdditionalCommitmentIfEBITDAExceed" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LeasesWeightedAverageDiscountRateAbstract" abstract="true" name="LeasesWeightedAverageDiscountRateAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_RestrictedCashAndCashEquivalentsInsuranceCoverageMember" abstract="true" name="RestrictedCashAndCashEquivalentsInsuranceCoverageMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseAccountsPayable" abstract="false" name="LiabilitiesSubjectToCompromiseAccountsPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_UnsecuredCreditorsMember" abstract="true" name="UnsecuredCreditorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_EventAxis" abstract="true" name="EventAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="endp_AssetsAndLiabilitiesLesseeTableTextBlock" abstract="false" name="AssetsAndLiabilitiesLesseeTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_PaymentsForProductAcquisitionCostsAndLicenseFees" abstract="false" name="PaymentsForProductAcquisitionCostsAndLicenseFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_FirstLienCreditorsMember" abstract="true" name="FirstLienCreditorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LondonInterBankOfferedRateLIBORMember" abstract="true" name="LondonInterBankOfferedRateLIBORMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_DebtorInPossessionTypeAxisDomain" abstract="true" name="DebtorInPossessionTypeAxisDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ScheduleOfLiabilitiesSubjectToCompromiseTableTextBlock" abstract="false" name="ScheduleOfLiabilitiesSubjectToCompromiseTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_CostReductionInitiatives" abstract="false" name="CostReductionInitiatives" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LidodermMember" abstract="true" name="LidodermMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsFreeCashFlowPerformanceMetricGrantsinPeriodPercentage" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsFreeCashFlowPerformanceMetricGrantsinPeriodPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_LossContingencyNumberOfRemainingDefendantsGranted" abstract="false" name="LossContingencyNumberOfRemainingDefendantsGranted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_InidentifiableIntangibleAssetsMember" abstract="true" name="InidentifiableIntangibleAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SanFranciscoMember" abstract="true" name="SanFranciscoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_CardinalHealthIncMcKessonCorporationAndCencoraIncMember" abstract="true" name="CardinalHealthIncMcKessonCorporationAndCencoraIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LossContingencyFundingCommitmentRelatedToSettlement" abstract="false" name="LossContingencyFundingCommitmentRelatedToSettlement" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_Endo401kPlanMember" abstract="true" name="Endo401kPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_EndoInternationalPLCMember" abstract="true" name="EndoInternationalPLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_CustomerProductAndSupplierConcentrationPolicyTextBlock" abstract="false" name="CustomerProductAndSupplierConcentrationPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_PublicSchollDistrictMember" abstract="true" name="PublicSchollDistrictMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_AcquisitionRelatedContingentConsiderationMember" abstract="true" name="AcquisitionRelatedContingentConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_OtherSpecialtyProductsMember" abstract="true" name="OtherSpecialtyProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_DisposalGroupIncludingDiscontinuedOperationLitigationRelatedAndOtherContingenciesNet" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationLitigationRelatedAndOtherContingenciesNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PlanOfReorganizationPercentageOfRightOfReceiveEquity" abstract="false" name="PlanOfReorganizationPercentageOfRightOfReceiveEquity" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="endp_InternationalPharmaceuticalsSegmentMember" abstract="true" name="InternationalPharmaceuticalsSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_AccruedLiabilitiesReturnsAndAllowancesCurrent" abstract="false" name="AccruedLiabilitiesReturnsAndAllowancesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired" abstract="false" name="PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_OpioidRelatedCasesMember" abstract="true" name="OpioidRelatedCasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsNetOfTaxAttributableToParent" abstract="false" name="IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsNetOfTaxAttributableToParent" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_IncomeLossBeforeEquityMethodInvestmentsNetOfTaxAttributableToParent" abstract="false" name="IncomeLossBeforeEquityMethodInvestmentsNetOfTaxAttributableToParent" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsAggregateIntrinsicValueVestedandExpectedtoVest" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsAggregateIntrinsicValueVestedandExpectedtoVest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_CapexReimbursementReceivableIncludedInAccountsReceivableNet" abstract="false" name="CapexReimbursementReceivableIncludedInAccountsReceivableNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_BrandedPharmaceuticalsSegmentMember" abstract="true" name="BrandedPharmaceuticalsSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_EuroDeferredSharesSharesAuthorized" abstract="false" name="EuroDeferredSharesSharesAuthorized" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="endp_StatuesOfLimitation" abstract="false" name="StatuesOfLimitation" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_FiniteLivedIntangibleAssetsOther" abstract="false" name="FiniteLivedIntangibleAssetsOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PotentialReimbursementClosingCost" abstract="false" name="PotentialReimbursementClosingCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_CVSHealthCorporationMember" abstract="true" name="CVSHealthCorporationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_OtherAcquisitionsExcludingVoltarenMember" abstract="true" name="OtherAcquisitionsExcludingVoltarenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" abstract="false" name="LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_RestructuringAndRelatedCostInventoryAdjustments" abstract="false" name="RestructuringAndRelatedCostInventoryAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DistrictCourtForTheEasternDistrictOfPennsylvaniaMember" abstract="true" name="DistrictCourtForTheEasternDistrictOfPennsylvaniaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_NevakarInjectablesIncMember" abstract="true" name="NevakarInjectablesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_ContractWithCustomerAssetIncreaseDecreasePercentage" abstract="false" name="ContractWithCustomerAssetIncreaseDecreasePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_LitigationSettlementInitialSettlementPayment" abstract="false" name="LitigationSettlementInitialSettlementPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DeferredTaxAssetsFixedAssetsIntangibleAssetsAndDeferredAmortization" abstract="false" name="DeferredTaxAssetsFixedAssetsIntangibleAssetsAndDeferredAmortization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_ResolutionSettlementGrossConsiderationPayable" abstract="false" name="ResolutionSettlementGrossConsiderationPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LehighValleyTechnologiesInc.Member" abstract="true" name="LehighValleyTechnologiesInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_EffectiveIncomeTaxRateReconciliationInvestingActivitiesAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationInvestingActivitiesAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_NumberOfInProcessResearchAndDevelopmentProjectsAcquired" abstract="false" name="NumberOfInProcessResearchAndDevelopmentProjectsAcquired" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_TreasuryStockPolicyTextBlock" abstract="false" name="TreasuryStockPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_SixPercentSeniorNotesDueTwoThousandTwentyEightMember" abstract="true" name="SixPercentSeniorNotesDueTwoThousandTwentyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_WeightedAverageRemainingLeaseTermAbstract" abstract="true" name="WeightedAverageRemainingLeaseTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_VareniclineTabletsMember" abstract="true" name="VareniclineTabletsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_ProductLiabilityMember" abstract="true" name="ProductLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion" abstract="false" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EventTwoMember" abstract="true" name="EventTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_OtherSterileInjectablesMember" abstract="true" name="OtherSterileInjectablesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_ParPharmaceuticalIncMember" abstract="true" name="ParPharmaceuticalIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation" abstract="false" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyNumberOfMunicipalities" abstract="false" name="LossContingencyNumberOfMunicipalities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_SegmentReportingInformationUnallocatedCorporateExpense" abstract="false" name="SegmentReportingInformationUnallocatedCorporateExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_A2017CreditAgreementMember" abstract="true" name="A2017CreditAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_StalkingHorseBidUCCProfessionalsMember" abstract="true" name="StalkingHorseBidUCCProfessionalsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_InventoryAdjustmentsMember" abstract="true" name="InventoryAdjustmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_ProductLineRevenueReportingThreshold" abstract="false" name="ProductLineRevenueReportingThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseLegalSettlementAccrual" abstract="false" name="LiabilitiesSubjectToCompromiseLegalSettlementAccrual" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_StalkingHorseBidOpioidAndMeshClaimantMember" abstract="true" name="StalkingHorseBidOpioidAndMeshClaimantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_StalkingHorseBidAndCanadianGovernmentMember" abstract="true" name="StalkingHorseBidAndCanadianGovernmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_AdequateProtectionPayments" abstract="false" name="AdequateProtectionPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PaymentsRelatedToReorganizationItemsNetOperatingActivities" abstract="false" name="PaymentsRelatedToReorganizationItemsNetOperatingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_StalkingHorseBidAndPublicSchoolDistrictCreditorsMember" abstract="true" name="StalkingHorseBidAndPublicSchoolDistrictCreditorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ManufacturingFacilitiesInChestnutRidgeNYAndIrvineCAAndUSProductRegulatoryApprovalsAndCertainRelatedProductInventoryMember" abstract="true" name="ManufacturingFacilitiesInChestnutRidgeNYAndIrvineCAAndUSProductRegulatoryApprovalsAndCertainRelatedProductInventoryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PotentialProceedsFromSettlementOfUnencumberedAssets" abstract="false" name="PotentialProceedsFromSettlementOfUnencumberedAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_GenericPharmaceuticalsSegmentMember" abstract="true" name="GenericPharmaceuticalsSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_TLCAgreementMember" abstract="true" name="TLCAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_AstoraMember" abstract="true" name="AstoraMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_DebtInstrumentExtendedMaturityModificationAmount" abstract="false" name="DebtInstrumentExtendedMaturityModificationAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_VASOSTRICTRelatedMattersMember" abstract="true" name="VASOSTRICTRelatedMattersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_LeaseRightofUseAsset" abstract="false" name="LeaseRightofUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DebtInstrumentCovenantLiquidityRequirement" abstract="false" name="DebtInstrumentCovenantLiquidityRequirement" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LitigationSettlementVoluntaryTrustAmount" abstract="false" name="LitigationSettlementVoluntaryTrustAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_RestructuringSupportAgreementMember" abstract="true" name="RestructuringSupportAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" abstract="false" name="SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsAndOtherRestructuringCostsMember" abstract="true" name="EmployeeSeparationContinuityAndOtherBenefitRelatedCostsAndOtherRestructuringCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SettlementFundsRollForward" abstract="true" name="SettlementFundsRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_PlansOtherThan2015PlanMember" abstract="true" name="PlansOtherThan2015PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_EuroDeferredSharesSharesIssued" abstract="false" name="EuroDeferredSharesSharesIssued" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="endp_FivePointThreeSevenFiveSeniorNotesDueOnTwoThousandTwentyThreeMember" abstract="true" name="FivePointThreeSevenFiveSeniorNotesDueOnTwoThousandTwentyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_LossContingencyStayOfApprovalMotionToExtendPeriod" abstract="false" name="LossContingencyStayOfApprovalMotionToExtendPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_LossContingencyPaymentPeriod" abstract="false" name="LossContingencyPaymentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_InterestPaymentsGracePeriod" abstract="false" name="InterestPaymentsGracePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_RestructuringInitiative2022Member" abstract="true" name="RestructuringInitiative2022Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SUPPRELINLAMember" abstract="true" name="SUPPRELINLAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_AdrenalinMember" abstract="true" name="AdrenalinMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent" abstract="false" name="AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember" abstract="true" name="FivePointSevenFiveSeniorNotesDueOnTwoThousandTwentyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_StalkingHorseBidOpioidClaimantMember" abstract="true" name="StalkingHorseBidOpioidClaimantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ConstructionCostIncurred" abstract="false" name="ConstructionCostIncurred" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyClaimsFiledByStatesNumber" abstract="false" name="LossContingencyClaimsFiledByStatesNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty" abstract="false" name="LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_LossContingencyNumberOfPutativeClassActions" abstract="false" name="LossContingencyNumberOfPutativeClassActions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_EffectiveIncomeTaxRateReconciliationExecutiveCompensationLimitationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationExecutiveCompensationLimitationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DebtorReorganizationItemsDebtValuationAdjustments" abstract="false" name="DebtorReorganizationItemsDebtValuationAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_IncreaseInTrustPayments" abstract="false" name="IncreaseInTrustPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EffectiveIncomeTaxRateReconciliationFinancingActivitiesAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationFinancingActivitiesAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseAccruedInterest" abstract="false" name="LiabilitiesSubjectToCompromiseAccruedInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DebtInstrumentQuarterlyPeriodicPaymentPercent" abstract="false" name="DebtInstrumentQuarterlyPeriodicPaymentPercent" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_InventoryNotYetAvailableForSaleNet" abstract="false" name="InventoryNotYetAvailableForSaleNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_StalkingHorseBidMeshClaimantMember" abstract="true" name="StalkingHorseBidMeshClaimantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_IntangibleAssetsNetIncludingGoodwillMeasurementInput" abstract="false" name="IntangibleAssetsNetIncludingGoodwillMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember" abstract="true" name="SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PlanOfReorganizationMaximumCashSettlementToBePaid" abstract="false" name="PlanOfReorganizationMaximumCashSettlementToBePaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PotentialSettlementMadeInEquityAmount" abstract="false" name="PotentialSettlementMadeInEquityAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SecondLienCreditorsMember" abstract="true" name="SecondLienCreditorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_AccruedLiabilitiesOtherSalesDeductionsCurrent" abstract="false" name="AccruedLiabilitiesOtherSalesDeductionsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_PaladinLabsIncMember" abstract="true" name="PaladinLabsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_Endo401kPlanMatchingTierTwoMember" abstract="true" name="Endo401kPlanMatchingTierTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_AllowancesforSalesReturnsandAllowances" abstract="false" name="AllowancesforSalesReturnsandAllowances" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_VASOSTRICTandorADRENALINMember" abstract="true" name="VASOSTRICTandorADRENALINMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_GainLossDispositionOfBusinessAndOtherAssets" abstract="false" name="GainLossDispositionOfBusinessAndOtherAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AssetImpairmentChargesMember" abstract="true" name="AssetImpairmentChargesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SharebasedCompensationAwardAdjustmentRate" abstract="false" name="SharebasedCompensationAwardAdjustmentRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_NinePointFivePercentSeniorNotesDueTwoThousandTwentySevenMember" abstract="true" name="NinePointFivePercentSeniorNotesDueTwoThousandTwentySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SixPointOneTwoFivePercentSeniorNotesDueTwoThousandTwentyNineMember" abstract="true" name="SixPointOneTwoFivePercentSeniorNotesDueTwoThousandTwentyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_NumberOfProductLicensesRevoked" abstract="false" name="NumberOfProductLicensesRevoked" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_EuroDeferredSharesMember" abstract="true" name="EuroDeferredSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_LossContingencyStayOfApprovalPeriod" abstract="false" name="LossContingencyStayOfApprovalPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_StalkingHorseBidMember" abstract="true" name="StalkingHorseBidMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember" abstract="true" name="SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_EventOneMember" abstract="true" name="EventOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_CumulativeAmountsAppliedAgainstAssetsPlacedInService" abstract="false" name="CumulativeAmountsAppliedAgainstAssetsPlacedInService" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_Endo401kPlanMatchingTierOneMember" abstract="true" name="Endo401kPlanMatchingTierOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_ContractwithCustomerLiabilityIncreaseDecrease" abstract="false" name="ContractwithCustomerLiabilityIncreaseDecrease" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_StockAwardMember" abstract="true" name="StockAwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_CanadianGovernmentMember" abstract="true" name="CanadianGovernmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_OtherIntangibleAssetsLineItems" abstract="true" name="OtherIntangibleAssetsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts" abstract="false" name="PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_ReimbursableConstructionCost" abstract="false" name="ReimbursableConstructionCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LitigationSettlementAmountAwardedToOtherPartyTerm" abstract="false" name="LitigationSettlementAmountAwardedToOtherPartyTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_DeferredTaxAssetsDeferredInterestDeduction" abstract="false" name="DeferredTaxAssetsDeferredInterestDeduction" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_GoingConcernPolicyTextBlock" abstract="false" name="GoingConcernPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_ScheduleOfStockholdersEquityLineItems" abstract="true" name="ScheduleOfStockholdersEquityLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_LitigationSettlementPotentialAdditionalAwardedToOtherParty" abstract="false" name="LitigationSettlementPotentialAdditionalAwardedToOtherParty" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_CardinalHealthIncMember" abstract="false" name="CardinalHealthIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_TermLoanFacilityMember" abstract="true" name="TermLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_ImpairmentOfPropertyPlantEquipmentAndIntangibleAssets" abstract="false" name="ImpairmentOfPropertyPlantEquipmentAndIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SavingsAndInvestmentPlanAndDeferredCompensationPlansTextBlock" abstract="false" name="SavingsAndInvestmentPlanAndDeferredCompensationPlansTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="endp_FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward" abstract="true" name="FiniteLivedIntangibleAssetsAccumulatedAmortizationRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_EuroDeferredSharesParorStatedValuePerShare" abstract="false" name="EuroDeferredSharesParorStatedValuePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="endp_ContractwithCustomerLiabilityIncreaseDecreasePercentage" abstract="false" name="ContractwithCustomerLiabilityIncreaseDecreasePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_OpioidRelatedCasesAndMeshRelatedCasesMember" abstract="true" name="OpioidRelatedCasesAndMeshRelatedCasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_DebtInstrumentBasisSpreadOnVariableRateFloor" abstract="false" name="DebtInstrumentBasisSpreadOnVariableRateFloor" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_EventDomain" abstract="true" name="EventDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_AmericanMedicalSystemsMember" abstract="true" name="AmericanMedicalSystemsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PERCOCETMember" abstract="true" name="PERCOCETMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PlanOfReorganizationSubjectToPrepaymentRightsTribalOpioidClaimants" abstract="false" name="PlanOfReorganizationSubjectToPrepaymentRightsTribalOpioidClaimants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_XiaflexMember" abstract="true" name="XiaflexMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_A2015ShareBuybackProgramMember" abstract="true" name="A2015ShareBuybackProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_BankruptcyClaimsAmountOfClaimsFiledExcludingRepetitiveClaims" abstract="false" name="BankruptcyClaimsAmountOfClaimsFiledExcludingRepetitiveClaims" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_NumberOfRegisteredShareholders" abstract="false" name="NumberOfRegisteredShareholders" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember" abstract="true" name="FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization" abstract="false" name="FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_FacilityServicePeriod" abstract="false" name="FacilityServicePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_DebtInstrumentDebtModificationCosts" abstract="false" name="DebtInstrumentDebtModificationCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LongtermDebtMaturityRepaymentDeadline" abstract="false" name="LongtermDebtMaturityRepaymentDeadline" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_MckessonCorporationMember" abstract="false" name="MckessonCorporationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_LossContingencyCharges" abstract="false" name="LossContingencyCharges" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DebtModificationExpense" abstract="false" name="DebtModificationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AcceleratedDepreciationChargesMember" abstract="true" name="AcceleratedDepreciationChargesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_DexlansoprazoleMember" abstract="true" name="DexlansoprazoleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_NumberOfPatentsInfringed" abstract="false" name="NumberOfPatentsInfringed" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_AdHocFirstLienGroupMember" abstract="true" name="AdHocFirstLienGroupMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_AssetsPlacedInServiceGross" abstract="false" name="AssetsPlacedInServiceGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AdjustedIncomeLossBeforeIncomeTax" abstract="false" name="AdjustedIncomeLossBeforeIncomeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_OtherIntangibleAssetsCostBasisAbstract" abstract="true" name="OtherIntangibleAssetsCostBasisAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_CashFlowLesseeAbstract" abstract="true" name="CashFlowLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
</xs:schema>
