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  <xsd:element id="endp_InventoryNotYetAvailableForSaleNet" name="InventoryNotYetAvailableForSaleNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="endp_LeaseRightofUseAsset" name="LeaseRightofUseAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="endp_LehighValleyTechnologiesInc.Member" name="LehighValleyTechnologiesInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_LidodermMember" name="LidodermMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LongtermDebtMaturityRepaymentDeadline" name="LongtermDebtMaturityRepaymentDeadline" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyAccrualPaymentsToPlaintiffCounsel" name="LossContingencyAccrualPaymentsToPlaintiffCounsel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" name="LossContingencyAccrualPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
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  <xsd:element id="endp_LossContingencyClaimsFiledByStatesNumber" name="LossContingencyClaimsFiledByStatesNumber" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_LossContingencyLawsuitFilingPeriod" name="LossContingencyLawsuitFilingPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" name="LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty" name="LossContingencyNumberOfCasesFiledByHospitalsHealthSystemsUnionsWelfareFundsOrOtherThirdParty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="endp_LossContingencyNumberOfPutativeClassActions" name="LossContingencyNumberOfPutativeClassActions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_LossContingencyStayOfApprovalPeriodHatchWaxmanAct" name="LossContingencyStayOfApprovalPeriodHatchWaxmanAct" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_NonVestedRestrictedStockMember" name="NonVestedRestrictedStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_NonVestedStockOptionsMember" name="NonVestedStockOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_NoteRepurchasesMember" name="NoteRepurchasesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_NumberOfCustomers" name="NumberOfCustomers" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OpioidRelatedMattersMember" name="OpioidRelatedMattersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherAcquisitionsMember" name="OtherAcquisitionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherEstablishedProductsMember" name="OtherEstablishedProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherIntangibleAssetsCostBasisAbstract" name="OtherIntangibleAssetsCostBasisAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherIntangibleAssetsLineItems" name="OtherIntangibleAssetsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_OtherPaymentsForLegalSettlements" name="OtherPaymentsForLegalSettlements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherSpecialtyProductsMember" name="OtherSpecialtyProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_OtherSterileInjectablesMember" name="OtherSterileInjectablesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_PERCOCETMember" name="PERCOCETMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ParPharmaceuticalInc.Member" name="ParPharmaceuticalInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts" name="PaymentForDebtExtinguishmentOrDebtPrepaymentCostAndDebtIssuanceCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ProductLiabilityMember" name="ProductLiabilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_ProductLineRevenueReportingThreshold" name="ProductLineRevenueReportingThreshold" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_PublicEmployeesRetirementSystemofMississippivs.EndoInternationalPLCMember" name="PublicEmployeesRetirementSystemofMississippivs.EndoInternationalPLCMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_RestrictedCashAndCashEquivalentsMember" name="RestrictedCashAndCashEquivalentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_RetentionBonusMember" name="RetentionBonusMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SUPPRELINLAMember" name="SUPPRELINLAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ScheduleOfGoodwillAndOtherIntangiblesTable" name="ScheduleOfGoodwillAndOtherIntangiblesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock" name="ScheduleofIntangibleAssetImpairmentChargesIncludingGoodwillTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_SegmentReportingInformationUnallocatedCorporateExpense" name="SegmentReportingInformationUnallocatedCorporateExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SeniorNotesMaturingDue2022Member" name="SeniorNotesMaturingDue2022Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_SettlementFunds" name="SettlementFunds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="endp_SettlementFundsAdditions" name="SettlementFundsAdditions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_SettlementFundsOther" name="SettlementFundsOther" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="endp_SettlementFundsPayments" name="SettlementFundsPayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="endp_SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" name="SettlementFundsPaymentsToPlaintiffCounselFromQualifiedSettlementFunds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SettlementFundsRollForward" name="SettlementFundsRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember" name="SevenPointFivePercentSeniorSecuredNotesDueTwentyTwentySevenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember" name="SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SixPercentSeniorNotesDue2025Member" name="SixPercentSeniorNotesDue2025Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember" name="SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_SpecialtyProductsMember" name="SpecialtyProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_StockAwardMember" name="StockAwardMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_TermLoanBFacilityDueTwoThousandTwentyFourMember" name="TermLoanBFacilityDueTwoThousandTwentyFourMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_TestopelMember" name="TestopelMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_ThreeMajorCustomersCardinalHealthInc.McKessonCorporationAndAmerisourceBergenCorporationMember" name="ThreeMajorCustomersCardinalHealthInc.McKessonCorporationAndAmerisourceBergenCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="endp_UpfrontAndMilestonePaymentsToPartners" name="UpfrontAndMilestonePaymentsToPartners" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_VASOSTRICTRelatedMattersMember" name="VASOSTRICTRelatedMattersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_VASOSTRICTandorADRENALINMember" name="VASOSTRICTandorADRENALINMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_VaginalMeshCasesMember" name="VaginalMeshCasesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_VasostrictMember" name="VasostrictMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="endp_XiaflexMember" name="XiaflexMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
