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  <xs:element id="endp_ResolutionSettlementGrossConsiderationPayableInInstallments" abstract="false" name="ResolutionSettlementGrossConsiderationPayableInInstallments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_PotentialSettlementMadeInEquityPercentage" abstract="false" name="PotentialSettlementMadeInEquityPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="endp_RestructuringInitiative2020Member" abstract="true" name="RestructuringInitiative2020Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_MeshRelatedCasesMember" abstract="true" name="MeshRelatedCasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SixPercentSeniorNotesDueTwoThousandTwentyEightMember" abstract="true" name="SixPercentSeniorNotesDueTwoThousandTwentyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_EuroDeferredSharesParorStatedValuePerShare" abstract="false" name="EuroDeferredSharesParorStatedValuePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="endp_LossContingencyNumberOfMunicipalities" abstract="false" name="LossContingencyNumberOfMunicipalities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_ExpensesRelatedToEquityAgreementCancellation" abstract="false" name="ExpensesRelatedToEquityAgreementCancellation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AdjustedIncomeLossBeforeIncomeTax" abstract="false" name="AdjustedIncomeLossBeforeIncomeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_TLCAgreementMember" abstract="true" name="TLCAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_SterileInjectablesSegmentMember" abstract="true" name="SterileInjectablesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_AdequateProtectionPayments" abstract="false" name="AdequateProtectionPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AcquisitionRelatedContingentConsiderationMember" abstract="true" name="AcquisitionRelatedContingentConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_OpioidRelatedCasesMember" abstract="true" name="OpioidRelatedCasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired" abstract="false" name="PaymentsToAcquireBusinessesAndAssetAcquisitionsNetOfCashAcquired" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyFundingCommitmentRelatedToSettlement" abstract="false" name="LossContingencyFundingCommitmentRelatedToSettlement" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion" abstract="false" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityAdjustmentsAndAccretion" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember" abstract="true" name="SevenPointTwoFivePercentSeniorNotesDueTwoThousandTwentyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_EuroDeferredStockValueIssued" abstract="false" name="EuroDeferredStockValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LiabilitiesSubjectToCompromiseAccountsPayable" abstract="false" name="LiabilitiesSubjectToCompromiseAccountsPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AssetImpairmentChargesMember" abstract="true" name="AssetImpairmentChargesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_PaymentsRelatedToReorganizationItemsNetOperatingActivities" abstract="false" name="PaymentsRelatedToReorganizationItemsNetOperatingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyClaimsFiledByStatesNumber" abstract="false" name="LossContingencyClaimsFiledByStatesNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_CashFlowLesseeAbstract" abstract="true" name="CashFlowLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="endp_StalkingHorseBidUCCProfessionalsMember" abstract="true" name="StalkingHorseBidUCCProfessionalsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_BankruptcyClaimsAmountOfClaimsFiledExcludingRepetitiveClaims" abstract="false" name="BankruptcyClaimsAmountOfClaimsFiledExcludingRepetitiveClaims" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_OpiodClaimantsMember" abstract="true" name="OpiodClaimantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_NumberOfPatentsInfringed" abstract="false" name="NumberOfPatentsInfringed" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization" abstract="false" name="FiniteLivedIntangibleAssetsTranslationAdjustmentsEffectOnAccumulatedAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EuroDeferredSharesSharesAuthorized" abstract="false" name="EuroDeferredSharesSharesAuthorized" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="endp_PotentialProceedsFromSettlementOfUnencumberedAssets" abstract="false" name="PotentialProceedsFromSettlementOfUnencumberedAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent" abstract="false" name="AccruedRoyaltiesandOtherDistributionPartnerPayablesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DisposalGroupIncludingDiscontinuedOperationLitigationRelatedAndOtherContingenciesNet" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationLitigationRelatedAndOtherContingenciesNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember" abstract="true" name="EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_VASOSTRICTRelatedMattersMember" abstract="true" name="VASOSTRICTRelatedMattersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_RestructuringSupportAgreementMember" abstract="true" name="RestructuringSupportAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_InventoryAdjustmentsMember" abstract="true" name="InventoryAdjustmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_LitigationSettlementVoluntaryTrustAmount" abstract="false" name="LitigationSettlementVoluntaryTrustAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_ProductLineRevenueReportingThreshold" abstract="false" name="ProductLineRevenueReportingThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_InventoryNotYetAvailableForSaleNet" abstract="false" name="InventoryNotYetAvailableForSaleNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember" abstract="true" name="FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="endp_IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsNetOfTaxAttributableToParent" abstract="false" name="IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsNetOfTaxAttributableToParent" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation" abstract="false" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlementsAndEffectOfCurrencyTranslation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" abstract="false" name="LossContingencyNumberOfCasesAllegingPersonalInjuryAndOrWrongfulDeath" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="endp_SegmentReportingInformationUnallocatedCorporateExpense" abstract="false" name="SegmentReportingInformationUnallocatedCorporateExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_SettlementFunds" abstract="false" name="SettlementFunds" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
