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    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2D0F3E409BFA687C89ED8AC08A59D32D_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2D0F3E409BFA687C89ED8AC08A59D32D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Basic</link:label>
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    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2D0F3E409BFA687C89ED8AC08A59D32D" xlink:to="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2D0F3E409BFA687C89ED8AC08A59D32D" xlink:type="arc" />
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    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_0DF03B1BC8F487E87A9D8AC08A59C9C2" xlink:to="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_0DF03B1BC8F487E87A9D8AC08A59C9C2" xlink:type="arc" />
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_AF2D41FEE628C1135C3C8AC090DCC297" xlink:type="locator" />
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    <link:label id="lab_endp_SomersetTherapeuticsLLCMember_8B93C2EE8A8030BB01698AC090DDBC83_documentation_en-US" xlink:label="lab_endp_SomersetTherapeuticsLLCMember_8B93C2EE8A8030BB01698AC090DDBC83" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Somerset Therapeutics, LLC [Member]</link:label>
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    <link:label id="lab_endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember_BF1FBB4E092C9C66A543A5273564A405_documentation_en-US" xlink:label="lab_endp_SixPointZeroPercentSeniorNotesDueTwoThousandTwentyThreeMember_BF1FBB4E092C9C66A543A5273564A405" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Six Point Zero Percent Senior Notes Due Two Thousand Twenty Three [Member]</link:label>
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    <link:label id="lab_endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember_4BB8C7CE788C24856C2CA527356412CD_terseLabel_en-US" xlink:label="lab_endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember_4BB8C7CE788C24856C2CA527356412CD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">5.875% Senior Secured Notes due 2024</link:label>
    <link:label id="lab_endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember_4BB8C7CE788C24856C2CA527356412CD_label_en-US" xlink:label="lab_endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember_4BB8C7CE788C24856C2CA527356412CD" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Five Point Eight Seven Five Percent Senior Secured Notes Due Twenty Twenty Four [Member]</link:label>
    <link:label id="lab_endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember_4BB8C7CE788C24856C2CA527356412CD_documentation_en-US" xlink:label="lab_endp_FivePointEightSevenFivePercentSeniorSecuredNotesDueTwentyTwentyFourMember_4BB8C7CE788C24856C2CA527356412CD" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Five Point Eight Seven Five Percent Senior Secured Notes Due Twenty Twenty Four [Member]</link:label>
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    <link:label id="lab_endp_A6.00SeniorNotesDue2025Member_C0B9CD8599A1BE1C36A1A52735647418_terseLabel_en-US" xlink:label="lab_endp_A6.00SeniorNotesDue2025Member_C0B9CD8599A1BE1C36A1A52735647418" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">6.00% Senior Notes due 2025</link:label>
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    <link:label id="lab_endp_A6.00SeniorNotesDue2025Member_C0B9CD8599A1BE1C36A1A52735647418_documentation_en-US" xlink:label="lab_endp_A6.00SeniorNotesDue2025Member_C0B9CD8599A1BE1C36A1A52735647418" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">6.00% Senior Notes Due 2025 [Member]</link:label>
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    <link:label id="lab_endp_TermLoanBFacilityDueTwoThousandTwentyFourMember_3052F66372A70A377FC9A527356459FD_terseLabel_en-US" xlink:label="lab_endp_TermLoanBFacilityDueTwoThousandTwentyFourMember_3052F66372A70A377FC9A527356459FD" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Term Loan B Facility Due 2024</link:label>
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    <link:label id="lab_endp_OtherDebtMember_FD14BABBA03DE92D91DFA5273565C8AF_terseLabel_en-US" xlink:label="lab_endp_OtherDebtMember_FD14BABBA03DE92D91DFA5273565C8AF" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other debt</link:label>
    <link:label id="lab_endp_OtherDebtMember_FD14BABBA03DE92D91DFA5273565C8AF_label_en-US" xlink:label="lab_endp_OtherDebtMember_FD14BABBA03DE92D91DFA5273565C8AF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Debt [Member]</link:label>
    <link:label id="lab_endp_OtherDebtMember_FD14BABBA03DE92D91DFA5273565C8AF_documentation_en-US" xlink:label="lab_endp_OtherDebtMember_FD14BABBA03DE92D91DFA5273565C8AF" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Other Debt [Member]</link:label>
    <link:loc xlink:href="endp-20180630.xsd#endp_OtherDebtMember" xlink:label="loc_endp_OtherDebtMember_FD14BABBA03DE92D91DFA5273565C8AF" xlink:type="locator" />
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    <link:label id="lab_us-gaap_DebtInstrumentLineItems_A8D7C27A3B24C4D1199CA52735650C76_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_A8D7C27A3B24C4D1199CA52735650C76" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument [Line Items]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentLineItems_A8D7C27A3B24C4D1199CA52735650C76_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems_A8D7C27A3B24C4D1199CA52735650C76" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_A8D7C27A3B24C4D1199CA52735650C76" xlink:type="locator" />
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    <link:label id="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_B69141D3E0E539A043D3A527356616AC_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_B69141D3E0E539A043D3A527356616AC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Effective interest rate (as percent)</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_B69141D3E0E539A043D3A527356616AC_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_B69141D3E0E539A043D3A527356616AC" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Interest Rate, Effective Percentage</link:label>
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    <link:label id="lab_us-gaap_DebtInstrumentFaceAmount_526183A27A0113429189A527356691FF_totalLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_526183A27A0113429189A527356691FF" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Principal Amount</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentFaceAmount_526183A27A0113429189A527356691FF_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount_526183A27A0113429189A527356691FF" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Face Amount</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_526183A27A0113429189A527356691FF" xlink:type="locator" />
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    <link:label id="lab_us-gaap_LongTermDebt_28CA3B0C1B07DCD01665A5273566075A_totalLabel_en-US" xlink:label="lab_us-gaap_LongTermDebt_28CA3B0C1B07DCD01665A5273566075A" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Carrying Amount</link:label>
    <link:label id="lab_us-gaap_LongTermDebt_28CA3B0C1B07DCD01665A5273566075A_label_en-US" xlink:label="lab_us-gaap_LongTermDebt_28CA3B0C1B07DCD01665A5273566075A" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-term Debt</link:label>
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    <link:label id="lab_us-gaap_LongTermDebtCurrent_78DF29913C0A6324FB8BA5273566E2D8_verboseLabel_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_78DF29913C0A6324FB8BA5273566E2D8" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Less current portion, net</link:label>
    <link:label id="lab_us-gaap_LongTermDebtCurrent_78DF29913C0A6324FB8BA5273566E2D8_label_en-US" xlink:label="lab_us-gaap_LongTermDebtCurrent_78DF29913C0A6324FB8BA5273566E2D8" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-term Debt, Current Maturities</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_78DF29913C0A6324FB8BA5273566E2D8" xlink:type="locator" />
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    <link:label id="lab_endp_DebtInstrumentFaceAmountExcludingCurrentMaturities_0D4951AD2A91D2352636A52735665447_terseLabel_en-US" xlink:label="lab_endp_DebtInstrumentFaceAmountExcludingCurrentMaturities_0D4951AD2A91D2352636A52735665447" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Principal amount of total long-term debt, less current portion, net</link:label>
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    <link:label id="lab_us-gaap_MaximumMember_0B663B4D3186013796E3F48E6A2FF426_terseLabel_en-US" xlink:label="lab_us-gaap_MaximumMember_1FCAAE4AE8C85D3A9CC253C5E369BF84" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maximum</link:label>
    <link:label id="lab_us-gaap_MaximumMember_0B663B4D3186013796E3F48E6A2FF426_label_en-US" xlink:label="lab_us-gaap_MaximumMember_1FCAAE4AE8C85D3A9CC253C5E369BF84" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maximum [Member]</link:label>
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    <link:label id="lab_endp_AstoraMember_4A1F852E8EB0BC0153B5D29092B1E9B5_terseLabel_en-US" xlink:label="lab_endp_AstoraMember_4A1F852E8EB0BC0153B5D29092B1E9B5" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Astora</link:label>
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