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  <xs:element id="endp_DeferredTaxLiabilityIntercompanyNotes" abstract="false" name="DeferredTaxLiabilityIntercompanyNotes" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_ContractwithCustomerLiabilityIncreaseDecrease" abstract="false" name="ContractwithCustomerLiabilityIncreaseDecrease" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet" abstract="false" name="AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_AssetAcquisitionConsiderationTransferredRoyaltyObligationsDischarged" abstract="false" name="AssetAcquisitionConsiderationTransferredRoyaltyObligationsDischarged" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_CardinalHealthIncMember" abstract="false" name="CardinalHealthIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_DebtInstrumentCovenantTriggerMaximumPrincipalAmountOfDebtInstruments" abstract="false" name="DebtInstrumentCovenantTriggerMaximumPrincipalAmountOfDebtInstruments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="endp_IntangibleAssetsAcquired" abstract="false" name="IntangibleAssetsAcquired" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember" abstract="true" name="EmployeeSeparationContinuityAndOtherBenefitRelatedCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_Endo401kPlanMatchingTierTwoMember" abstract="true" name="Endo401kPlanMatchingTierTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_LongtermDebtMaturityRepaymentDeadline" abstract="false" name="LongtermDebtMaturityRepaymentDeadline" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="endp_ColchicineTabletsMember" abstract="true" name="ColchicineTabletsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="endp_AssetImpairmentChargesMember" abstract="true" name="AssetImpairmentChargesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_AcquisitionRelatedContingentConsiderationMember" abstract="true" name="AcquisitionRelatedContingentConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_ProductLiabilityMember" abstract="true" name="ProductLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="endp_EffectiveIncomeTaxRateReconciliationFinancingActivitiesNonDeductibleBadDebtExpenseAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationFinancingActivitiesNonDeductibleBadDebtExpenseAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="endp_DebtInstrumentCommitmentsNotExtendedAmount" abstract="false" name="DebtInstrumentCommitmentsNotExtendedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
